早发型重度子痫前期患者胎盘组织M―CSF、CRH和HO―2表达的研究[摘要]目的研究早发型重度子痫前期患者胎盘组织中巨噬细胞集落刺激因子（MCSF）、促肾上腺皮质激素释放激素（CRH）、血红素氧化酶-2（HO-2）的表达，探讨它们在早发型重度子痫前期发病机制中的作用。方法整群选择选自2013年9月―2014年8月在郑州大学第三附属医院住院的孕妇73例，年龄22～37岁，孕周32～37周。早发型重度子痫前期患者25例，晚发型重度子痫前期患者23例，正常妊娠对照组25例进行实验对照研究，应用免疫组化方法研究M-CSF、CRH、HO-2的表达情况。结果①三期组孕妇之间年龄、终止妊娠孕周比较，差异均无统计学意义（P>0.05）（见表1）。②与正常妊娠组比较，早发型及晚发型重度子痫前期组M-CSF表达水平均明显升高；早发型组M-CSF表达水平明显高于晚发型组。③与正常妊娠组比较，早发型及晚发型组CRH表达水平均明显升高；早发型组CRH表达水平明显高于晚发型组。④与正常妊娠组比较，早发型及晚发型组HO-2表达水平均明显降低；早发型组HO-2表达水平低于晚发型组，差异无统计学意义（P>0.05）。结论胎盘中MCSF、CRH的表达增加和HO-2表达降低可能与早发型重度子痫前期的发病有关。[关键词]重度子痫前期；巨噬细胞集落刺激因子；促肾上腺皮质激素释放激素；血红素氧化酶-2；胎盘[]R5[文献标识码]A[]1674-0742（2016）05（b）-0081-03[Abstract]ObjectiveToresearchthemacrophagecolonystimulatingfactor，corticotropinreleasinghormoneandhemeoxygenase-2expressionsofplacentatissuesinpatientswithearlyonsetseverepreeclampsiaanddiscusstheireffectsintheearlyonsetseverepreeclampsiapathogenesis.MethodsThedeliverywomenwhoseageswerebetween22and37andgestationalweekswerebetween32and37hospitalizedinourhospitalfromSeptember2013toAugust2014wereselected，amongthem，25caseswerewithearlyonsetseverepreeclampsia，23caseswerewithlateonsetseverepreeclampsia，25caseswithnormalpregnancywereselectedasthecontrolgroup，andtheM-CSF，CRHandHO-2expressionswereresearchedbytheimmunohistochemicalmethod.Results（1）Thedifferencesintheageandterminatedgestationalweekbetweenthethreegroupshadnostatisticalsignificance，P>0.05（2）TheM-CSFexpressionlevelobviouslyincreasedintheearlyandlateonsetseverepreeclampsiagroupscomparedwiththatinthecontrolgroup；theM-CSFexpressionlevelintheearlyonsetgroupwasobviouslyhigherthanthatinthelateonsetgroup.（3）TheCRHexpressionlevelintheearlyandlateonsetgroupsobviouslyincreasedcomparedwiththatinthecontrolgroup，theCRHexpressionlevelintheearlyonsetgroupwasobviouslyhigherthanthatinthelateonsetgroup.（4）TheHO-2expressionlevelintheearlyandlateonsetgroupsobviouslydecreasedcomparedwiththatinthecontrolgroup；theHO-2expressionlevelintheearlyonsetgroupwaslowerthanthatinthelateonsetgroup，andthedifferencehadnostatisticalsignificance，P>0.05.---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---ConclusionTheincreaseofMCSFandCRHexpressionsanddecreaseofHO-2expressionmaybecorrelatedwiththeonsetofearlyonsetseverepreeclampsia.[Keywords]Severepreeclampsia；Macrophagecolonystimulatingfactor；Corticotropinreleasinghormone；Hemeoxygenase-2；Placenta早发型重度子痢前期是指发生于孕34周以前的重度子痫前期[1]，多伴有胎儿生长受限和很高的医源性早产率，围生儿死亡率高达13.3%[2]。早发型重度子痫前期因发病早，病程进展快，常伴有较多并发症合并症，较早发生多脏器功能受损，严重威胁孕妇和胎儿安危，有较高的孕产妇和围生儿病死率。因此，寻找早发型重度子痫前期的病因，如何从病因上着手控制并减少早发型重度子痫前期的发生是产科医生面临的难题，现报道如下。1资料与方法1.1一般资料在患者知情同意的前提下，整群选取2013年9月―2014年8月在郑州大...