胃黏膜脱垂症内镜下治疗体会【摘要】目的:观察内镜下射频联合药物治疗胃黏膜脱垂疗效,为胃黏膜脱垂的治疗寻找有效方法。方法:对2009年1月-2012年12月经过胃镜、胃肠顿餐造影检查确诊为胃黏膜脱垂患者80例,随机分为观察组和对照组。观察组先采取内镜下对脱垂的胃黏膜进行射频点灼治疗,然后服用雷贝拉畔10mg,每天2次,连续28d,铝镁加混悬液15ml,每天3次,连续28d;对照组:不予射频治疗,服药与观察组相同。两组均于疗程结束后复查胃镜判断疗效。结果:观察组治愈率27.5%,显著高于对照组的7.5%(字2=5.77,P<0.05),观察组总有效率82.5%,显著高于对照组的55%(字2=7.04,P<0.05)o术后随访6个月,观察组1例复发(2.5%),对照组有8例复发(20%),两组差异有统计学意义(字2=4.51,P〈0・05)。结论:内镜下射频联合雷贝拉卩坐、铝镁加混悬液疗效好,不良反应少,易于推广。【关键词】胃黏膜脱垂;内镜下射频治疗;雷贝拉呼;铝镁加混悬液TreatmentofEndoscopicMucosalProlapse/LVXiao-fang,MARuiTi,FANGLi-feng,etal.//MedicalInnovationofChina,2013,10(20):109-111[Abstract]Objective:Toobserveendoscopicradiofrequencycombinedwithdrugtherapyingastricmucosaprolapseefficacyforthetreatmentofgastricmucosaprolapsetofindeffectivemethods.Method:Endoscopy,gastrointestinalbariummealdiagnosedgastricmucosaprola---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---pseof12monthsfromJanuary2009to2012,after80patientswererandomlydividedintoobservationgroupandcontrolgroup.TheobservationgroupwasfirsttakenEndoscopicgastricmucosaprolapsetheRFpointblanchtreatment,andthentakingrabeprazole10mgbidx28dAlmagatesuspension15mltidX28d;controlgroup:notoradiofrequencytreatment,medicationandobservationgroups.Tnbothgroupsaftertheendoftreatmenttodeterminetheefficacyofendoscopy・Result:Theobservationgroup,thecureratewas82.5%,significantlyhigherthanthatinthecontrolgroup55%,asignificantdifference(字2二5.77,P<0.05)theobservationgrouptotaleffectiverateof82.5%,significantlyhigherthanthatinthecontrolgroup55%,astatisticallydifference(字2=7.04,P<0.05)・1(2.5%)patientsrelapsedpatientswerefollowedupfor6monthsintheobservationgroup,8patientsrelapsed(20%)inthecontrolgroup,thetwogroupsofpatientswithasignificantdifference(字2二4.51,P〈0.05)・Conclusion:EndoscopicradiofrequencycombinedwithrabeprazoleAlmagatesuspensioniseffective,feweradversereactions,andeasytospread.【Keywords]Gastricmucosaprolapse;Endoscopicradiofrequencyablation;Rabeprazole;AlmagatesuspensionFirst-authorsaddress:TheFirstPeople'sHospitalofZhengzhouCity,Zhengzhou450000,Chinadoi:10.3969/j.issn.1674-4985.2013.20.054胃幽门处有较厚的黏膜,正常的幽门插约肌的内面黏膜形成环形皱製,称为幽门瓣,当幽门括约肌收缩时,幽门瓣可将幽门封闭,以阻止胃内容物进入十二指肠[1]。假若胃窦部黏膜炎症、水肿,或黏膜肥厚,正常活动性能丧失时,幽门处的黏膜松弛;当胃蠕动过强时,肥大的黏膜作为异物,被增强的胃蠕动挤入(脱入)幽门管,进入十二指肠,引起胃黏膜脱垂症。胃黏膜脱垂也叫胃窦部黏膜脱垂,顾名思义,就是胃窦部的黏膜松弛、起皱、延长呈游离脱垂状,随着胃的蠕动,脱垂的黏膜被推入幽门口,把幽门口部分或全部阻塞,食物通过时受到阻碍,甚至完全不能进入丁二指肠,从而产---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---生一系列症状[2]。本病易发于中老年人,男性的发病率约为女性的2倍。主耍临床表现为无规律性的上腹痛,常伴腹胀、暧气、恶心和呕吐。胃黏膜脱垂症的发病机理尚不清楚,就目前所知,一切能引起胃剧烈蠕动的因素,均可引起本病[3]。本病传统以内科药物治疗为主,但无特效药物可供使用,故自2009年1月-2012年12月,笔者采用了内镜下射频联合...