冠心病诊断中超敏C反应蛋白及血清同型半胱氨酸联合检查意义评析【摘要】目的探索冠心病口'断中超敏C反应蛋白（hs-CRP）与血清同型半胱氨酸（HCY）联合检查的临床价值。方法120例疑似冠心病患者作为观察组（不稳定型心绞痛、心肌梗死、稳定型心绞痛各40例），40例健康体检者作为对照组，对所有研究对象进行hs-CRP与血清HCY联合检查。结果观察组稳定型心绞痛患者的HCY为(12.58±4.25)pmol/L,B型脑钠肽(BNP)为(186.25±85.36)pg/ml,hs-CRP为(1.68±0.89)ng/ml,肌红蛋白为(124.36±36.47)ng/ml,肌钙蛋白为(0.74±0.95)ng/ml;心肌梗死患者的HCY为(13.98±4.74)pmol/L,BNP为(451.36±89.36)pg/ml,hs-CRP为(1.75±1.27)ng/ml,肌红蛋白为(154.25±38.61)ng/ml,肌钙蛋白为(1.6510.47)ng/ml;不稳定型心绞痛患者的HCY为(15.96±5.18)pmol/L,BNP为(765.36±105.69)pg/ml,hs-CRP为(1.87±1.47)ng/ml,肌红蛋白为(174.85±42.95)ng/ml,肌钙蛋白为(1.78±1.42)ng/ml,观察组各种患者各指标数据均高于对照组的(9.56±2.47)pmol/L、(59.36±30.47)pg/mk【关键词】冠心病；超敏C反应蛋白血清同型半胱氨(0.21±0.05)ng/mL(86.31±24.05)ng/mk(0.31±0.14)ng/ml,差异有统计学意义(P0.05\结论hs-CRP联合血清HCY在冠心病患者中具有较高的诊断价值酸；诊断DOI:10.14163/jki.11-5547/r.2O17.09,015Evaluationandanalysisonsignificanceofjointinspectionofhigh-sensitivityC-reactiveproteinandserumhomocysteineindiagnosisofcoronaryheartdiseaseLIUGuo-lian,LIXia,CHENYu-feng.DepartmentofLaboratory,GuangdongProvinceMaomingCityPeople5sHospital,Maoming525000,China[Abstract]ObjectiveToexploreclinicalvalueofjointinspectionofhigh-sensitivityC-reactiveprotein(hs-CRP)andserumhomocysteine(HCY)indiagnosisofcoronaryheartdisease.MethodsTherewere120suspectedcoronaryarterydiseasepatientsasobservationgroup(with40casesinunstableanginapectoris,myocardialinfarctionandstableanginapectoris),and40healthexaminationpeopleascontrolgroup.Allstudysubjectsreceivedjointinspectionofhs-CRPandserumHCY.ResultsStableanginapectorispatientsinobservationgrouphadHCYas(12.58±4.25)pmol/L,B-typenatriureticpeptide(BNP)as(186.25±85.36)pg/ml,hs-CRPas(1.68±0.89)ng/ml,myohemoglobinas(124.36±36.47)ng/ml,troponinas(0.74±0.95)ng/ml.MyocardialinfarctionpatientshadHCYas(13.98±4.74)pmol/L,BNPas(451.36±89.36)pg/ml,hs-CRPas(1.75±1.27)ng/ml,myohemoglobinas(154.25±38.61)ng/ml,troponinas(1.65±0.47)ng/ml.UnstableanginapectorispatientshadHCYas(15.96±5.18)pmol/L,BNPas(765.36±105.69)pg/ml,hs-CRPas(1.87±1.47)ng/ml,myohemoglobinas(174.85±42.95)ng/ml,troponinas(1.78±1.42)ng/ml.Allwerehigherthan(9.56±2.47)pmol/L,(59.36±30.47)pg/ml,(0.21±0.05)ng/ml,(86.31±24.05)ng/mland(0.31±0.14)ng/mlincontrolgroup,andtheirdifferenceshadstatisticalsignificance(P0.05).ConclusionJointdetectionofhs-CRPandserumHCYshowshighdiagnosticvalueinchoronaryheartdiseasepatients.[Keywords]Coronaryheartdisease;High-sensitivityC-reactiveprotein;Serumhomocysteine;DiagnosisMl冠心病常见的病理基础为冠状动脉粥样硬化，若未及时干预，可直接威胁患者生命，对此应加强患者临床诊断和治疗［1］。目前临床常用的实验室指标为血清HCY、hs-CRP,其中HCY属于含硫基氨基酸，是血栓形成和动脉粥样硬化形成的主要危险因素，hs-CRP属于炎症标记物，有研究表明，将两种实验室指标联合检测，可提高临床诊断正口—率［2］。本文旨在探索冠心病诊断中hs-CRP与血清HCY联合检查的临床意义，具体的内容报告如下1资料与方法1.1一般资料选择2015年9月~2016年9月收治的120例疑似冠心病患者作为观察组，同期40例健康体检者作为对照组。本次研究对象均知情，且签署书面同意书。排除标准：危重症者；排除沟通障碍者；存在精神家族史者；依从性较差者。观察组患者年龄36〜6...