腰椎间盘退变的MRI与病理相关性评价及临床研究研究生：姚高文导师：陈建常副教授摘要目的：通过MRI信号强度变化与组织病理学改变对比研究，并测定椎间隙高度变化，来准确评价椎间盘退变程度，为椎间盘退变的诊断、治疗及预后评估提供依据。方法：收集髓核标本，术前测定MRI相对信号强度，术后标本测量水份含量；统计分析水含量与MRI相对信号强度相关性；根据软骨样细胞数量，退变程度分类，评价MRI影像学改变与病理学改变相关性或一致性；测定非手术组椎间隙高度并与手术组椎间隙高度变化进行比较，分析椎间隙高度变化与椎间盘突出程度相关性。结果：MRI相对信号强度与水分含量有相关性，t「值为2.53,PvO.05；II、III类椎间盘内软骨样细胞数分别为24.8±9.3.13.2±8.1,t检验示二者之间具有统计学差异。组织病理学与MRI两种方法评价腰椎间盘退变K值为0.72,K值0.4・0.75之间，说明这两种评价方法具有很高一致性；手术组和非手术组椎间隙高度变化与椎间盘突出具有高度相关性，t「值为2.27,P小于0.05o结论：腰椎间盘退变时组织病理学和MRI这两种方法评价退变程度具有一致性，MRI能准确定量评价椎间盘退变程度。MRI信号强度变化与椎间盘退变后水含量有显著相关性。利用MRI测定椎间隙高度的变化程度与椎间盘突出程度具有高度一致性，椎间隙高度变化可作为临床评价指标之一，可为临床上选择合理治疗方案、判断疾病转归和探索新的治疗方法提供依据。关键词：椎间盘；退变；病理；MRI；评价LumbarintervertebraldiscdegenerationMRIwithpathologiccorrelationevaluationandclinicalresearchPostgraduate:Yaogaowensupervisor:ProfChenjianchangAbstractsObjective:OnstudytherelationofMRImanifestationandpathologicalchangetoevaluatedegenerationofintervertebraldisc.Offerabasisfordiagnosistreatmentandprognosisassessment.Methods:NPspecimens,preoperativedeterminationoftherelativesignalintensityofMRIandpostoperativemeasurementofmoisturecontentinsamples；statisticalanalysisoftherelativewatercontentandMRIsignalintensitycorrelation；accordingtothenumberofcartilagecells,degenerationclassification,evaluationMRIimagingchangesassociatedwithpathologicalchangesorconsistency；determinationofnon・surgicalgroupandsurgicaldischeightanddischeightchangesofgroupcomparisonandanalysisofintervertebraldischeightandthedegreeofcorrelation.Results:Operationgroup,therelativesignalintensityofMRIwerecorrelatedwithmoisturecontent,6-valueof2.53,Plessthan0.05；operationgroupII、IIIclassofcartilage-likecellswithintheintervertebraldiscwere24.8土9.3,13.2土8.1,ttestindicatedtwostatisticaldifferencebetween.HistopathologyandMRIevaluationoftwomethodsoflumbardiscdegenerationKappa=0.72,Kvaluesbetween0.4-0.75,indicatingthatthetwoevaluationmethodsareconsistent；surgicalgroupandnonsurgicalgroupintervertebraldischeightandhasahighcorrelation,trvalueof2.27,P<0.05.Conclusion:MRImanifestationwascoherencetothepathologicchangeofthedegenerativelumbardisc.MRIcanaccuratelyevaluatediscdegeneration.MRIsignalintensitychangeshaverelationtodiscdegenerationandthewatercontent.MeasuredbyMRIextentofdischeightanddiscchangesinhighdegreeofconsistency,theintervertebralspaceheightcanbeusedasindicatorofclinicalevaluation,areasonablechoicefortheclinicaltreatmentplan,judgmentondiseaseoutcomeandtoexplorenewtreatmentmethod.Keywords:Intervertebraldisc；degeneration；pathology；MRI；evaluation中英文缩略词对照表英文缩写英文全名中文译名LIDHLumbarintervertebraldischerniation腰椎间盘突出症MRImagneticresonanceimaging核磁共振成像论文独创性说明本人中明所呈交的学位论文是在我个人在导师的指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人己...