养血清脑颗粒治疗老年偏头痛性眩晕的效果doi：10.3969/j.issn.1007-614x.2014.22.50摘要目的：对比观察养血清脑颗粒对老年偏头痛性眩晕（MV）的治疗效果。方法：2011年10月-2013年3月收治MV患者78例，随机分为3组，养血清脑组给予养血清脑颗粒4g,3次/日。氟桂利嗪组给予氟桂利嗪5〜10mg,1次/晚。倍他司汀组给予倍他司汀4〜8mg/次，2〜4次/日。治疗12周，观察头痛、眩晕指标的变化及药物不良反应。结果：治疗后3组眩晕指标均显著改善。养血清脑颗粒对MV患者头痛指标的影响优于倍他司汀，对头痛时间、程度的影响优于氟桂利嗪，对眩晕频率的影响与氟桂利嗪相当，对眩晕时间的影响与倍他司汀、氟桂利嗪相当，对眩晕强度的作用优于氟桂利嗪。治疗后，3组间眩晕残障量表（Dili）总评分差异无统计学意义（卩＞0.05）,养血清脑颗粒对DHT分项情绪评分的改善作用优于倍他司汀和氟桂利嗪。养血清脑组不良反应轻，耐受性良好。结论：养血清脑颗粒治疗老年MV安全、有效。关键词偏头痛性眩晕；养血清脑颗粒；氟桂利嗪；倍他司汀；预防治疗EffectofYangXueQingNaogranuleinthetreatmentofelderlymigrainevertigoZhouIluaxiangl,ChenChunful,XuLiang2,WangWei3,WangGuoqing4,CaoYuling5,YanZhihui6Shandong),2500211DepartmentofNeurology,thePeople"sHospitalofZaozhuangArea,Shandong2771012DepartmentofNeurology,thePeople"sHospitalofLiaochengArea,Shandong2520003DepartmentofNeurology,theProvincialHospitalAffiliatedtoShandongUniversity(JinanCity,DepartmentofNeurology,thePeople，sHospitalofBinzhouArea,Shandong2566104DepartmentofNeurology,thePeople，sHospitalofJiningArea,Shandong2720005DepartmentofNeurology,YantaishanHospitalofYantaiCity,Shandong2640086Abstractobjective：Tocompareandobservethetreatment,effectofYangXueQingNaogranuleinelderlymigrainevertigo(MV)•Methods:78MVcaseswereselectedfromOctober2011toMarch2013.Theywererandomlydividedinto3groups.YangXueQingNaogroupweregivenYangXueQingNaogranule4g,3timesoneday.Flunarizinegroupweregivenflunarizine5〜10mg,1timeonenight.Betahistinegroupweregivenbetahistine4~8mgonetime,2~4timesoneday.After12weeksoftreatment,thechangsofheadache,vertigoindicatorsanddrugadversereactionwereobserved.Results：Aftertreatment,thevertigoindicatorof3groupsweresignificantlyimproved.TheeffectofYangXueQingNaogranuleontheheadacheindexofMVpatientswasbetterthanbetahistine・Theeffectofthetimeanddegreeofheadachewasbetterthanflunarizine.Theeffectofthevertigofrequencywasequaltoflunarizine・Theeffectofthevertigotimewasequaltobetahistineandflunarizine.Theeffectofthevertigointensitywasbetterthanflunarizine・Aftertreatment,dizzinessdisabilityscale(DHI)of3groupshadnosignificantdifferenceintotalscore(P>0.05)・YangXueQingNaogranulewasbetterthanbetahistineandflunarizineontheimprovingofDHIitemizedmoodscore.YangXueQingNaogranulehadiniIdadversereaction,anditstoleraneewaswel1.Conclusion：YangXueQingNaogranuleinthetreatmentofelderlyMVissafeandeffective・KeywordsMigrainousvertigo；YangXueQingNaogranule；Flunarizine；Betahistine；卩reventivetreatment偏头痛是一种临床常见的慢性复发性脑功能异常。眩晕为神经内科患者最常见的就诊原因之一，其中一部分患者的眩晕发作与偏头痛存在密切联系。近年来，学者们逐渐发现偏头痛患者眩晕的发病时间、持续时间不符合国际头痛协会(THS)头面痛分类中关于“偏头痛先兆”的界定标准,难以用偏头痛的“先兆症状”来解释。同时由于基底型偏头痛的诊断标准过于严格，无法将此类患者纳入其中，从而提出了偏头痛性眩晕(migrainousvertigo,MV)的概念。木研究对比观察养血清脑颗粒对MV的影响，旨在探讨养血清脑颗粒在老年患者临床应用中的有效性和安全性。资料与方法2011年10月-2013年3月收治老年MV患者78例，男23...