Clinicalfeaturesdiagnosisandtreatmentofelderlypatientswithdrug-inducedliver[Keywords]elderly;druginducedliverDrug-inducedliverinjury(drug-inducedliverinjury,DILI),drugsinthetreatmentprocess,duetothecytotoxicdamagecausedbythedrugoritsmetabolitesintheliver,orliverduetoallergicreactionstodrugsandtheirmetabolitesdisease[1elderlydruginducedlivergenerallyreferstotheDILIpatientsovertheageof65yearsold,theagethegreaterthehighertheincidenceofsenileelderlydruginducedlivertheelderlydigestivesystemofcommondiseasesandfrequently-occurringdisease,apotentiallylife-threateningtoxicdiseases,organdysfunction,underlyingdiseases,typesofmedicationmajoritylarge,easytocauseliverdamage,theelderlydruginducedlivermoreandmoreattention,itisnecessarytoreducetheimmunefunctionoftheelderly,investigatetheclinicalfeatures.Easilyleadtodrug-inducedliverfoundationThediseasemostelderlypatientswithavarietyofunderlyingdiseases.Duetochronicdiseasessuchas:1kidneydisease,chronicbronchitis,tuberculosis,coronaryheartdisease,hypertension,diabetes,cancer,autoimmunediseasesandothersystemicdiseases,decreasedbodyresistance,needtotakealargenumberofdrugstocontrolthedisease;elderlyDILIprobabilityofoccurrenceincreaseswithincreasingage,theageofthebiologicaleffectsofthedrug,especiallythechangeofthelivercausedbydecreasedbloodflowofdrugs,drugstotheliverfrommicrovascularthecelldiffusingcapacityhaschanged[2].2drug-inducedliverreactiontypesandtheirrepresentativesDrugdrug-inducedliverdamagecanbetheresultofordinarytherapeuticdosesofthedrugcannotanticipatespecificreaction,canalsocausetoxicreactionsduetotheingestionoflargedosesofhepatotoxicdrugs,eitherinvolvingliverparenchymalcellsorbilesecretionfunctionofacuteliverinjury,canalsobeinsidiousdevelopmentofchronicliverinjuryismainlydividedintoacuteactivehepatitistype,typeoflivercelldamage,acuteintrahepaticcholestasistypeandmixedtype[3].extensiveliteraturereportedcauseelderlyDILIthelargest2proportionofChinesemedicineclass[4,5],followedbyacetaminophen,antibiotics,non-steroidalanti-inflammatorydrugs,amiodarone,andanti-TBdrugs[5],withpatientswithnon-toxicChinesemedicinemisconceptionsandusualabuseofantibiotics.Clinicalmanifestationsofdrug-inducedliverinjuryVerycomplex,themostcommonclinicalmanifestationsofsenileDILIissimilartoacutejaundicehepatitisorcholestatichepatitisperformance,oftenfever,fatigue,lossofappetite,hepatomegaly,jaundice,andserumALT,ASTincreasedlightbywithdrawalsymptomssubsideinashortperiodoftime,cancauseseverefulminantliverfailure.LinkstofreepapersDownloadCenterhttp://eng.hi138.comThemainbasisforthediagnosisofdruginducedliverThetheonsettimeprocesscharacteristicsandclinicaldiagnosticcriteriaandtheexclusionofotherfactors,thecharacteristicsofthetimeincludethefollowingaspects:(1)suspectedofdrugadministrationtotheonsetofthemajorityinthe1to12weeks,butthe3pasthasbeenthedrugexposurehistoryorsensitizedpatientsmayonsetwithinarelativelyshortperiodoftime(1to2days),ayearago,takingdrugsisthebasicruleoftheincentivesofacutedrug-inducedliverinjury.(2)drugtreatmentstopabnormalliverfunctionandliverdamagedisappear,oftenwithinafewweekscanbecompletelyrestored.clinicalmanifestationssuchwithdrawaltransaminasedecreasedbymorethan50%oftheweek,verymeaningfuldiagnosticdisappearwithinafewdays.(3)occasionallyagaingiventhedrugcancauseliverAbnormalrecurrence.Butmaynotintentionallyre-givesuspecteddrugs,inparticul...