中药口服液体制剂掩味技术的研究进展于福欣1郭茜1王瑞红2刘晓放21黑龙江中医药大学（哈尔滨150040）2黑龙江省医药工业研究所（哈尔滨150040）摘要目的：综述各种可用于口服液体制剂的掩味技术及目前中药口服液体制剂掩味技术的研究现状。方法:查阅近十几年来的中外文献期刊和各国专利,对各种口服液体制剂的掩味技术进行了分类总结。结果:以适当的方法对中药口服液体制剂进行了初步的掩味研究，使该种剂型掩味技术取得了一定的进展。结论:人们对药物的掩味要求越来越高，我们应该开发更为有效的掩味方法。关键词：掩味；中药口服液体制剂;矫味剂：Q81文献标码：A文章编码：1006-2882（2009）03-306-03ProgressofTasteMaskingTechnologyInOralLiquidPreparationofTraditionalChineseMedicineYuFuxin,etalHeilong激angUniversityofTraditionalChineseMedicine(Harbin150040)Abstract：Objective:SummaryofTasteMaskingTechnologythatcanbeuesdinoralliquidprepara-tionandthecurrentsituationoftastemaskingtechnologyinoralliquidpreparationoftradition-alChinesemedicineatthepresenttime.Methods:RefertotheChineseandforeignLiteratureperi-odicalsandthevariousnationalpatentsystem,Classifiedandsumupeverykindoftastemaskingtechnologyinoralliquidpreparation.Results:Tocarryoutapilotstudyinoralliquidprepara-quenceinvolvedinthetranscriptionalcontrolofAtFer1andZmFer1plantferritingenesbyiron[J].JBiolChem,2001,276(8):5584-5590.[19]LobreauxS,YewdallSJ,BriatJF,etal.Aminoacidsequenceandpredictedthreedimensionalstructureofpeaseed(Pisumsativum)ferritin[J].BiochemJ,1992,288:931-939.[20]程志强，郭泽建，徐晓晖，柴荣耀，李德葆.转铁蛋白基因增强水稻对氧化胁迫与稻瘟病菌的抗性[J].中国水稻科学,2003,17(1):85-88.[21]Engler-BlumG,MeierM,FrankJ,MullerGA.ReductionofbackgroundproblemsinnonradioactiveNorthernandSouthernblotanalysesenableshighersensitivi-[24]郝建军，刘延吉[M].植物生理学试验技术.沈阳:辽宁农业科学技术出版社,2001:71-73,144-145,180-181.[25]AttipalliRR,KolluruVC,MunusamyV.Drought-inducedresponsesofphotosynthesisandantioxidantmetabolisminhigherplants[J].JPlantPhysiol,2004,161(11):1189-1202.[26]BecanaM,MoranJF,Iturbe-OrmaetxeI.Iron-dependentoxygenfreeradicalgenerationinplantssubjectedtoenvironmentalstress:toxicityandantioxidantprotection[J].PlantSoil,1998,201:137-147.[27]ChrisB,MarcVH,DirkI.Superoxidedismutaseandstresstolerance[J].AnnuRevPlantPysidPlantMolBid,1992,43:83.[28]McCordJM,FridovichI,Superoxidedismutase:Anen-zymicfunctionforerythrocuprein(hemocuprein)[J].JBiolChem,1969,244:6049-6055.[29]FridovichI.Superoxidedismutase[J].AnnuRevBiovhem,1975,44:147-159.[30]GotoF,YoshiharaT,TaroM,etal.Geneticimprovementofironcontentandstressadaptationinplantsus-ingferritingene[J].BiotechnolGenetEngRev,2001,18:tythat32P-basedhybridizations[J].Anal1993,210(2):235-244.Biochem,[22]GiannopolitisCN,RiesSK.SuperoxidedismutaseⅠ:Occurrenceinhigherplant[J].Plantphysiol,1977,59:309-314.[23]MeadJF.Freeradicalmechanismoflipiddamage,aconsequenceforcellularmembranes[M].In:ProyorWAed.FreeRadicalsinBiology.NewYork:AcademicPress,1976:185-210.351-372.收稿日期：2009-04-黑龙江医药Heilong激angMedicineJournalVol.22No.32009-307-tionoftraditionalChinesemedicinebyanappropriateapproach.Sothatthetastemaskingtechnol-ogyhasmadesomeprogress.Conclusion:People'srequirementonthetastemaskingisincreasing,weshouldimprovethemoreeffectivetastemaskingmethods.Keywords:TasteMasking;OralliquidpreparationoftraditionalChinesemedicine;thehandoftaste.中药口服液体制剂系选用合理方法，提取中药有效成分在无菌或半无菌条件下灌制制成的液体...