DOIʒ10．13192/j．issn．1000-1719．2014．10．056中医辨证治疗老年性痴呆的疗效分析胡文雷,林海飞(乐清市人民医院中西医结合科,浙江乐清325601摘要:目的:研究中医辨证方法治疗老年性痴呆患者的疗效。方法:选择2011年1月—2013年10月本科接诊的60例老年性痴呆的患者进行研究。按照随机数表法,随机均分为观察组和对照组。对照组采用常规西药治疗,观察组采用中医辨证分型进行治疗。治疗后,分析比较两组患者的血脂及血液流变学的变化情况,采用简易智力状态量表(MMSE、日常能力量表积分(ADL及蒙特利尔认知量表(MoCA对两组患者的认知、行为功能进行评分,并采用相关疗效评价标准评价两组患者的疗效及不良反应情况。结果:治疗后,观察组患者的血脂及血液流变学各指标均明显改善,治疗前后比较有显著性差异(P＜0．01;对照组患者治疗前后的血脂及血液流变学各指标无显著改变(P＞0．05。两组患者的MMSE及MoCA评分均明显升高(P＜0．01,ADL均明显降低(P＜0．01,但观察组患者治疗后的MMSE及Mo-CA均明显高于对照组(P＜0．01,ADL评分明显低于对照组(P＜0．01。观察组患者的总有效率(86．67%明显高于对照组(53．33%,两组有效率比较有统计学意义(u=－2．0180,P=0．0436。两组患者的不良反应发生率无显著性差异(χ2=0．7407,P=0．3894。结论:中医辨证方法治疗老年性痴呆患者的疗效显著,值得临床推广。关键词:痴呆;老年性;中医;辨证中图分类号:Ｒ749．16文献标志码:B文章编号:1000-1719(201410-2164-03CurativeEffectofSyndromeDifferentiationofTraditionalChineseMedicineTreatmentforAlzheimer'sDiseaseHUWenlei,LINHaifei(YueqingPeople'sHospitalofIntegratedMedicine,Yueqing325601,Zhejiang,ChinaAbstract:Objective:TostudythecurativeeffectofsyndromedifferentiationoftraditionalChinesemedicinetreatmentforAlzheimer'sdisease．Methods:60caseswithAlzheimer'sdiseasepatientsfromJanuary2011toOctober2013inourhospitalwerestudied．Accordingtoarandomnumbertablemethod,theywererandomlydividedintoobservationgroupandcontrolgroup．ThecontrolgroupwastreatedwithconventionaltreatmentmeasureswhiletheobservationgrouptreatedwithsyndromedifferentiationoftraditionalChinesemedicine．Aftertreatment,changesinlipidandhemorheologyofthetwogroupswerecompared．Themini－mentalstateexamination(MMSE,thedailycapacityscaleintegration(ADLandtheMontrealCognitiveScale(MoCAofthetwogroupswereusedtoevaluatethebehavioralfunctionscoreandtheuseofefficacyandadversereactionsrelatedtoefficacye-valuationcriteriawasevaluated．Ｒesults:Aftertreatment,thebloodrheologyparametersoftheobservationgroupweresignificantlyimprovedandtherewasasignificantdifference(P＜0．01．Thebloodrheologyofthecontrolgroupbeforeandaftertreatmentdidnotchangesignificantly(P＞0．05．TheMMSEandMoCAscoresweresignificantlyhigher(P＜0．01andADLwassignifi-cantlylower(P＜0．01buttheMMSEandMoCAweresignificantlyhigher(P＜0．01intwogroups．ADLscoresintheobser-vationgroupweresignificantlylowerthanthatofthecontrolgroup(P＜0．01．Thetotalefficiencyofobservationgroup(86．67%wassignificantlyhigherthanthatofthecontrolgroup(53．33%andtheefficiencyofthetwogroupswasstatisticallysig-nificant(u=－2．0180,P=0．0436．Theincidenceofadversereactionsofthetwogroupswerenotsignificantlydifferent(χ2=0．7407,P=0．3894．Conclusion:ChinesesyndromedifferentiationtherapytreatmentforAlzheimer'spatientsisremarkable,wor-thyofpromotion．Keywords:dementia;elderly;traditionalChinesemedicine;sydnromedifferentiation收稿日期:2014－05－08作者简介:胡文雷(1969－,男,浙江乐清人,副主任中医师,学士,研究方向:老年性痴呆治疗。老年性痴呆是一种起病隐匿的进行性发展的神经系统退行性疾病[1]。患者常表现为记忆力减退、人格及行为改变等,是老年人的常见病[2...