盐酸氨澳索辅助治疗新生儿呼吸窘迫综合征疗效观察【摘要】目的探讨盐酸氨漠索辅助治疗新生儿呼吸窘迫综合症的治疗效果。方法选取我院2006年7月"2009年5月收治的40例新生儿呼吸窘迫患儿的临床资料，随机分为治疗组(20例)和对照组(20例)，对照组患者应用常规基础治疗，治疗组在常规治疗的基础上加用盐酸氨漠索30mg/kg/d,使用5%葡萄糖注射液5ml缓慢泵入，每天4次,治疗3"4do比较两组患者的临床表现以及Pa02和PaC02的变化。结果治疗组患者的呼吸困难和呻吟的症状明显减轻或者消失，疗效优于对照组患者，两组患者的疗效比较差异有统计学意义(p<0.05),治疗组患者的血气分析优于对照组患者。结论新生儿呼吸窘迫患者早期使用盐酸氨澳索临床疗效好，可以避免气管插管和机械通气率，疗效满意，值得在临床推广。【关键词】新生儿呼吸窘迫症盐酸氨漠索临床疗效中图分类号：R722文献标识码：A文章编号：1005-0515(2011)1-019-02AmbroxoladjuvanttreatmentofneonatairespiratorydistresssyndromeGAOJin(DepartmentofNeonatologyChildren"sHospital,Kunming,Yunnan,Kunming,Yunnan650034,Chin)[Abstract]ObjectiveToinvestigatetheadjuvanttreatmentofambroxolinthetreatmentofneonatairespiratorydistresssyndromeresuIts.MethodsThehospitalinJuly2006~May200940patientswereadmittedwithrespiratorydistressinchildrenwithneonatalclinicaldatawererandomlydividedintotreatmentgroup(20cases)andcontrolgroup(20cases),patientswithnormalcontrolgroupthebasisofthetreatmentgrouponthebasisofconventionaltherapyplusambroxol30mg/kg/d,using5m1of5%glucoseinjectionpumpslowly,day4,treatment3~4d・Theclinicalmanifestationswerecompared,andchangesinPa02andPaC02.ResuItsThepatientswithsymptomsofdyspneaandmoaningsignificantlyreducedoreliminated,effectivethanthecontrolgrouppatients,theefficacyofthetwogroupswerestatisticallysignificantdifference(p参考文献[1]吴敬德，凌霄，席延卫•反相高效液相色谱法测定注射用盐酸氨澳索的含量[J].山东大学学报(医学版),2008,(06)：3564-3567.[2]TandonBUN,BemauauJ,O'GradyJ,etal.RecommendatonsoftheInternationalAssociationfortheStudyoftheLiverSubcommitteeonnomenclatureofacuteandsubacuteliverfailureEJ]・JGastroenterolHepatol,2009,14(3)：403-404.[3]刘艳平.氨澳索预防和治疗早产儿呼吸窘迫综合征临床分析.儿科药学杂志，2005,11(6)：35.[4]庄旭琴，杨康群，李玉宝.高效液相色谱法测定盐酸氨漠索滴丸的含量[J]・山西医药杂志,2009,(08)：145-147.[5]JorisH,SudreP,MoessingerA.ApplicationofCPAPinnewbornswithgestationalagebelow34weekslowersintubationrateandshortensoxygentherapywithoutalteringmortalityandmortality.SchweizMedWochenschr,2008,130(49)：1887〜1892.[6]冉德森，马劲光，张文伟，钟运娣•阿莫西林与盐酸氨漠索治疗气切后肺部感染[J].药物流行病学杂志,2004,(01)：136-138.[7]WhitsettJA.Geneticdisordersofsurfactanthomeostasis[J]・PaediatrRespirRev,2006,7(Supol1):S240-S242[8]DanielJWegner,TorbjomHertzberg,HillaryBHeins,etal.AmajordeletioninthesurfactantproteinBgenecausinglethalrespiratorydistress[J]・ActaPediatrica,2007,96：516-520.[9]徐淑玲，于风琴，张家洁.盐酸氨澳索预防早产儿呼吸窘迫综合征疗效观察[J].实用儿科临床杂志,2006,(08)：30-34.[10]胡晓，唐章华，陈涛.盐酸氨漠索治疗新生儿吸入性肺炎疗效观察•中华优生与遗传杂志，2009,13(4)：88.[ll]UpadhyayA,DeorariA.ContinuousPositiveAirwayPressure一AGentlerApproachtoVentilatiori.IndianPediatric,2010,41：459-469.[12]EdithR,Schmid,PeterH.DangelandGabrielV.Due,TheuseofnasalCPAPinnewbornswithrespiratorydistresssyndrome・IntensiveCareMedicin,2007,24(11)：125-130.
