窦性心率震荡的临床研究[摘要]日的:探讨急性心肌梗死患者和扩张型心肌病患者的室性心律失常Z后的窦性心率变化与预后关系。方法:检测40例急性心肌梗死患者组、25例扩张型心肌病患者组及50例冠心病非急性心肌梗死伴有室性早搏组(对照组)的室性心律失常之后的窦性心率变化[震荡初始(T0)、震荡斜率(TS)]、左室射血分数(LVEF)3项指标,并观察3项指标与1年内死亡发生率的关系。结果:①急性心肌梗死组震荡初始(T0)为(-0.38±2.34)%,震荡斜率(TS)为(2・30±1・10)ms/RR;扩张型心肌病组震荡初始为(-0.38+2.26)%,震荡斜率为(4.67±2.86)ms/RR;对照组震荡初始为(-2.26±3.16)%,震荡斜率为(8.60±6.84)ms/RR,3组比较差异冇统计学意义,P0.05;震荡斜率、LVEF比较差异有统计学意义,P0.05。④3组各指标与1年内的死亡发生率组间比较差异无统计学意义,P>0.05o结论:室性心律失常Z后窦性心率震荡不一定能预测死亡率,死亡率的高低在于该种疾病病变的严重程度。[关键词]窦性心率震荡;震荡初始;震荡斜率;预后;研究[]R541.7+3[文献标识码]A[J1674-4721(2010)11(a)-037-04ClinicalstudyofsinusheartrateturbulenceHUANGZuogui,DUGuowei,YINBo(DepartmentofCardiology,TheChongqingThreeGorgesCentralHospital,Chongqing404000,China)[Abstract]Objective:Toinvestigatetheacutemyocardialinfarctionanddilatedcardiomyopathyinpatientswithventriculararrhythmiasinpatientswithsinusrhythmafterthechangeandprognosis.Methods:40patientswithacutemyocardialinfarctiongroup,25patientswithdilatedcardiomyopathygroupand50casesofcoronaryheartdiseaseassociatedwithprematureventricularcontractionsofnon-acutemyocardialinfarction(controlgroup)ofventriculararrhythmiasinusrhythmafterthechange[turbuleneeonset(TO),turbuleneeslope(TS)],leftventricularejectionfraction(LVEF)3indicators,andobservethethreeindicesandtheincideneeofdeathwithin1yearrelationship.ResuIts:①Theinitialshockinacutemyocardialinfarction(TO)was(一0・38±2・34)%,turbulenceslope(TS)was(2.30±1.10)ms/RR;dilatedcardiomyopathyinitia’lshockwas(-0.38+2.26)%,turbuleneeslopewas(4.67+2.86)ms/RR;Theinitialshockcontrolgroupwas(-2.26土3.16)%,turbulenceslopewas(60土6.84)ms/RR,3statisticallysignificantdifferencebetweengroups,P0.05;turbuleneeslope,LVEFwasstatisticallysignificantdifferenee,P0.05.④3groupindexandtheincideneeofdeathwithin1yearbetweenthetwogroupswasnosignificemtdifference,P>0.05・Conclusion:Theventriculararrhythmiasinusrhythmaftertheshockmaynotbeabletopredictmortality,mortalityofthediseaseisthe1evelofdiseaseseverity.[Keywords]Sinusheartrateturbulence;Turbulenceonset;Turbuleneeslope;Prognosis;Research窦性心率震荡(heartrateturbulence,HRT)是近10年来提出的一项无创心电检查指标,它是描述一次室性早搏(ventricularprenmaturecomplexes,VPC)之后窦性心率(先加速后减速)的短期波动变化,可对心肌梗死后患者的危险分层及心脏猝死有效的独立预测指标,还可对心力衰竭、高血压左室肥大、糖尿病、扩张型心肌病、急性冠脉综合征等患者发生心脏事件也有较高的预测价值[l-12]o本文就随机检测40例急性心肌梗死(AMI)患者组、25例扩张型心肌病患者组和50例冠心病非急性心肌梗死(nonAMT)患者(对照组)的室性心律失常之后的窦性心率变化与预后关系探讨如下:1资料与方法1.1一般资料40例急性心肌梗死(AMI)组,男30例,女10例,年龄45~86(65±21)岁25例扩张型心肌病组,男M例,女11例,年龄35〜75(60±18)岁。50例冠心病非急性心肌梗死(nonAMI)伴有室性早搏(对照组),男25例,女25例,年龄25-70(58±25)岁。AMI组、扩张型心肌病组、对照组3组患者的临床资料比较,见表1。3组患者的年龄、性别、体重指数、血压、心率、总胆固醇、吸烟例数比较差异无统计学意义,P>0.05o而糖尿病、三酰甘油、HDL-C(高密度脂蛋白胆固醇)、LDL-C(低密度脂蛋白胆...