乳腺癌彩色多普勒血流成像与雌激素受体、人表皮生长因子受体2、p53和Ki-67的相关性分析张鹏飞)王茂2,冉兵,#陕西中医药大学第二附属医院'超声科，2肿瘤乳腺外科，陕西咸阳712000摘要：目的分析乳腺癌彩色多普勒血流成像(CDFI)特征与雌激素受体(ER)、人表皮生长因子受体2(HER2)、p53及Ki.67的相关性。方法分析76例乳腺癌患者的CDFI特征(肿瘤直径、边缘毛刺征、微钙化、血流分级、淋巴结转移、后方回声衰减)，并采用Spearman法分析乳腺癌CDFI特征与ER.HER2.p53及Ki-67的相关性。结果乳腺癌患者乳腺癌组织中ER、HER2、p53及Ki.67阳性表达率分别为73.68%(56/76)、60.53%(46/76)、48.68%(37/76).40.79%(31/76),其中ER阳性表达率最高，Ki-67阳性表达率最低。有边缘毛刺征、血流分级为0~1级、有淋巴结转移的乳腺癌患者乳腺癌组织中ER阳性表达率均高于无边缘毛刺征、血流分级为2〜3级、无淋巴结转移者(P<0.05)o有微钙化、血流分级为2〜3级、有淋巴结转移的乳腺癌患者乳腺癌组织中HER2阳性表达率均高于无微钙化、血流分级为0~1级、无淋巴结转移者(P<0.05)。血流分级为2〜3级、有淋巴结转移的乳腺癌患者乳腺癌组织中p53及Ki-67阳性表达率均高于血流分级为0~1级、无淋巴结转移者(P<0.05)o乳腺癌患者乳腺癌组织中ER阳性表达率与肿瘤边缘毛刺征、淋巴结转移均呈正相关(P<0.05),与血流分级呈负相关(P<0.05),而与肿瘤直径、微钙化、后方回声衰减均无相关性(P>0.05)。乳腺癌患者乳腺癌组织中HER2阳性表达率与肿瘤微钙化、血流分级、淋巴结转移均呈正相关(P<0.05),而与肿瘤直径、边缘毛刺征、后方回声衰减均无相关性(P>0.05)o乳腺癌患者乳腺癌组织中p53、Ki-67阳性表达率与血流分级、淋巴结转移均呈正相关(P<0.05),而与肿瘤直径边缘毛刺征、微钙化、后方回声衰减均无相关性(P>0.05)o结论乳腺癌患者CDFI特征与ER.HER2.p53及Ki-67阳性表达存在一定的相关性，在预测乳腺癌生物学特性中具有一定的指导价值。关键词：彩色多普勒成像；雌激素受体；人表皮生长因子受体2；p53；Ki-67中图分类号：R737.9文献标志码：Adoi：10.11877/j.issn.1672-1535.2021.19.20.09StudyonthecorrelationbetweencolorDopplerflowimagingofbreastcancerwiththelevelsofestrogenreceptor,humanepidermalgrowthfactorreceptor2,p53andKi-67ZHANGPengfei1,WANGMao2,RANBing,#DepartmentofUltrasound,departmentofBreastCancerSurgery,SecondAffiliatedHospitalofShaanxiUniversityofTraditionalChineseMedicine,Xianyang712000,Shaanxi,ChinaAbstract:ObjectiveToanalyzethecorrelationbetweencolorDopplerflowimaging(CDFI)ofbreastcancerwiththelevelsofestrogenreceptor(ER),humanepidermalgrowthfactorreceptor-2(HER2),anti-oncogenep53andKi-67.MethodTheCDFIfeatures(tumordiameter,marginalburr,microcalcification,bloodflowclassification,lymphnodemetastasis,andposteriorattenuation)wereanalyzedin76patientswithbreastcancer.ThecorrelationbetweenCDFIcharacteristicsofbreastcancerwithER,HER2,p53andKi-67wereanalyzedbySpearman.ResultThepositiveexpressionratesofER,HER2,p53andKi-67inpatientswithbreastcancerwere73.68%(56/76),60.53%(46/76),48.68%(37/76)and40.79%(31/76)),respectively.Amongthem,thepositiveexpressionrateofERwasthehighest,andpositiveexpressionrateofKi-67wasthelowest.ThepositiverateofERexpressioninbreastcancerpatientswithmarginalburrs,bloodflowclassification0-1gradeandlymphnodemetastasiswerehigherthanthosewithoutmarginalburrs,bloodflowclassification2-3gradeandlymphnodemetastasis(P<0.05).ThepositiverateofHER2expressioninbreastcancerpatientswithmicrocalcification,bloodflowclassification2-3gradeandlymphnodemetastasiswerehigherthanthosewithoutmicrocalcification,bloodflowclassification0-1gradeandlymphnodemetastasis(P<0.05).Thepositiveexpressionratesofp53andKi-67inbreastcancerpatientswithbloodflowclassification2-3grad...