特发性血小板减少性紫癜合并血小板无效输注的临床治疗研究【摘要】目的：研究?c分析特发性血小板减少性紫癜合并血小板无效输注的临床治疗。方法：选取2014年4月-2016年8月本院收治的特发性血小板减少性紫癜合并血小板无效输注的26例患者作为研究对象，采用奇偶分组法分为对照组和观察组，各13例。两组患者入院后均进行常规治疗，在此基础上，对照组患者加大血小板输注剂量进行治疗，而观察组患者则在输注血小板前静脉滴注丙种球蛋白治疗。治疗过程中，详细记录两组患者出血症状消失时间、血小板上升时间、血小板达到正常时间及住院时间，对比两组患者各临床指标差异；治疗结束后，对比两组患者的临床治疗效果；分别检测两组患者治疗前和治疗后1、24h的血小板数量，对比变化情况；同时对比观察两组患者的不良反应发生率。结果：观察组患者出血症状消失时间、血小板上升时间、血小板达到正常时间及住院时间均显著优于对照组，差异均有统计学意义（P<0.05）。观察组患者临床治疗总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者血小板数量比较，差异无统计学意义（P>0.05）；治疗后1、24h，两组患者血小板数量均明显多于治疗前，差异均有统计学意义（P<0.05），且观察组患者血小板数量均多于对照组，差异均有统计学意义（P<0.05）。两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论：对特发性血小板减少性紫癜合并血小板无效输注患者，采用丙种球蛋白静脉滴注治疗效果较好，可在较短时间内使血小板数量增多，达到止血效果，从而缩短患者住院时间，且治疗过程中不良反应较少，安全性较高，值得临床推广应用。【关键词】特发性血小板减少性紫癜；血小板无效输注；丙种球蛋白ResearchofClinicalTreatmentofIdiopathicThrombocytopenicPurpuraComplicatedwithIneffectivePlateletTransfusion/HUANGJun.//MedicalInnovationofChina，2017，14（09）：018-021【Abstract】Objective：Tostudyandanalyzetheclinicaltreatmentofidiopathicthrombocytopenicpurpuracomplicatedwithineffectiveplatelettransfusion.Method：26patientswithidiopathicthrombocytopenicpurpuracomplicatedwithineffectiveplatelettransfusionandwhoacceptedtreatmentsinourhospitalfromApril2014toAugust2016wereselectedastheresearchobjects，andtheyweredividedintocontrolgroupandobservationgroupbytheevenandoddgroupingmethod，13casesineachgroup.Twogroupsofpatientsweregivenroutinetreatment，andonthisbasis，thepatientsincontrolgroupwereincreasedplatelettransfusiondosefortreatment，whilethepatientsinobservationgroupweregivenintravenousgammaglobulintreatmentbeforeintravenousimmunoglobulintherapy.Then，thetimeofdisappearanceofbleedingsymptoms，thetimeofplateletrise，thenormaltimeofplateletandthehospitalizationtimeoftwogroupswererecordedduringthetreatment，andthedifferencesofclinicalparametersoftwogroupswerecompared.Aftertheendoftreatment，theclinicaltreatmenteffectoftwogroupswerecomparedaccordingtothestandardofclinicaleffect，andtheplateletcountoftwogroupsweredetectedbeforeandaftertreatmentfor1hand24h，andthechangesituationwerecompared.Atthesametime，theoccurrenceofadversereactionsymptomsandnumberoftwogroupswererecordedduringthetreatment，andtheincidenceofadversereactionswerecompared.Result：Thetimeofdisappearanceofbleedingsymptoms，thetimeofplateletrise，thenormaltimeofplateletandthehospitalizationtimeinobservationgroupweresignificantlybetterthanthoseincontrolgroup，thedifferenceswerestatisticallysignificant（P<0.05）.Thetotaleffectiverateinobservationgroupwashigherthanthatofcontrolgroup，thedifferencewasstatisticallysignificant（P<0.05）.Thenumberofplateletsoftwogroupsbeforetreatmentwasless，andtherewasnosignificantdifferencebetweenthetwogroups（P...