复方丹参滴丸联合坎地沙坦酯片治疗老年慢性心力衰竭的疗效及安全性［摘要］目的探讨复方丹参滴丸联合坎地沙坦酯片治疗老年慢性心力衰竭(chronicheartfa订ure,CHF)的疗效及安全性。方法选取80例CHF患者，随机分为观察组和对照组，每组40例。对照组仅给予坎地沙坦酯片，观察组给予复方丹参滴丸联合坎地沙坦酯片。比较两组左心室射血分数(leftventricularejectionfraction,LVEF)、左室舒张末期内径(leftventricularenddiastoliediameter,LVEDD)>6min步行距离、脑钠肽(brainnatriureticpeptide,BNP)、肿瘤坏死因子-a(tumornecrosisfactor-a,TNF-a)、超敏C反应蛋白(highsensitivityC-reactiveprotein,hs-CRP)、临床疗效及不良反应发生率。结果治疗后，与对照组比较，观察组LVEDD显著降低，同时LVEF及6min步行距离显著增高(P<0.05)；观察组血清BNP、TNF-a及hs-CRP水平较对照组显著降低(P<0.05)o观察组临床疗效显著优于对照组(P〈0・05)。两组不良反应发生率比较差异无统计学意义(P>0.05)o结论复方丹参滴丸联合坎地沙坦酯片治疗CHF可显著改善心功能，减轻炎症反应。［关键词］慢性心力衰竭；复方丹参滴丸；坎地沙坦酯片;老年■IN［］R541.61［文献标识码］B［］1673-9701(2016)24-0117-03CurativeeffectsandsafetyofcompoundDanshenDrippingPillscombinedwithCandesartanCilexetilTabletsinthetreatmentofelderlychronicheartfailureWEIYingDepartmentofVasculocardiology,thePeople，sHospitalofHechiCityinGuangxiZhuangAutonomousRegion,Hechi547000,China［Abstract］ObjectiveTodiscussthecurativeeffectsandsafetyofcompounddanshendrippingpillscombinedwithcandesartancilexetiltabletsinthetreatmentofelderlychronicheartfailure(CHF)・Methods80patientswithCHFwereselected,andwererandomlyassignedtotheobservationgroupandthecontrolgroup,with40patientsineachgroup・Thecontrolgroupwasonlygivencandesartancilexetiltablets,andtheobservationgroupwasgivencompounddanshendrippingpillscombinedwithcandesartancilexetiltablets.Leftventricularejectionfraction(LVEF),leftventricularenddiastoliediameter(LVEDD),6-minwalkingdistance,brainnatriureticpeptide(BNP),tumornecrosisfactor-a(TNF-a),highsensitivityC-reactiveprotein(hs-CRP),clinicalcurativeeffectsandincidencerateofadversereactionswerecomparedbetweenthetwogroups・ResultsAfterthetreatment,LVEDDintheobservationgroupwaslowerthanthatinthecontrolgroup,LVEFand6-minwalkingdistanceintheobservationgroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0.05)；serumBNP,TNF-aandIL~6levelsweresignificantlylowerthanthoseinthecontrolgroup(P<0.05)・Theclinicalcurativeeffectsintheobservationgroupweresignificantlybetterthanthoseinthecontrolgroup(P〈0・05)・Therewasnostatisticallysignificantdifferenceoftheincidenceofadversereactionsbetweenthetwogroups(P>0・05)・ConclusionCompounddanshendrippingpillscombinedwithcandesartancilexetiltabletsinthetreatmentofCHFareabletosignificantlyimprovecardiacfunctionandreduceinflammatoryreactions.
