[摘要]目的探討扶正化瘀胶囊联合异甘草酸镁治疗失代偿期肝硬化临床疗效及对肝功能、肝纤维化指标的影响。方法选取20XX年1月～20XX年6月于唐山市传染病医院和华北理工大学附属医院住院的失代偿期肝硬化患者120例，按照随机数字表法分为对照组和病例组，每组各60例。对照组给予常规保肝治疗+异甘草酸镁治疗，病例组给予常规保肝治疗+异甘草酸镁+扶正化瘀治疗。两组均治疗2周。观察两组患者的临床疗效及治疗前后肝纤维化指标及肝功能变化。结果病例组临床有效率为900%，较对照组的867%显著升高，差异有统计学意义（P<0.05）。治疗后，两组肝功能、肝纤维化指标总胆红素（TBIL）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、层黏连蛋白（LN）、Ⅳ型胶原（CIV）、透明质酸（HA）、Ⅲ型前胶原（PCⅢ）水平降低，白蛋白（ALB）、胆碱酯酶（CHE）水平升高，差异有统计学意义（P<0.05）。治疗后，与对照组比较，病例组TBIL、ALT、AST、LN、CIV、HA、PCⅢ水平降低，ALB、CHE水平升高，差异有统计学意义（P<0.05）。结论扶正化瘀联合异甘草酸镁治疗失代偿期肝硬化患者效果显著，能够明显改善肝功能和肝纤维化程度，具有协同作用。[关键词]扶正化瘀；异甘草酸镁；失代偿期肝硬化；肝功能；肝纤维化[]R572[文献标识码]A[]1673-7210（20XX）04（b）-0138-04ClinicaleffectofFuzhengHuayuCapsulescombinedwithMagnesiumIsoglycerateinthetreatmentofdecompensatedcirrhosisLIXiaoyong1ZHANGGuoshun2DepartmentofHepatology，TangshanCityHospitalforInfectiousDiseases，HebeiProvince，Tangshan063000，China；DepartmentofGastroenterology，AffiliatedHospitalofNorthChinaUniversityofScienceandTechnology，HebeiProvince，Tangshan063000，China[Abstract]ObjectiveToinvestigatetheeffectofFuzhengHuayuCapsulescombinedwithMagnesiumIsoglycerateonliverfunctionandhepaticfibrosisinpatientswithdecompensatedcirrhosis.Metho党史Atotalof120caseswithdecompensatedcirrhosishospitalizedinTangshanCityHospitalforInfectiousDiseasesandAffiliatedHospitalofNorthChinaUniversityofTechnologyfromJanuary20XXtoJune20XXwereselected.Accordingtorandomnumbertablemethod，thepatientsweredividedintocontrolgroupandcasegroupwith60casesineachgroup.ThecontrolgroupwasgivenconventionalliverprotectionplusMagnesiumIsoglycyrrhizate，andthecasegroupwasgivenconventionalliverprotectionplusMagnesiumIsoxalateandFuzhengHuayuCapsules.Bothgroupsweretreatedfor2weeks.Clinicalefficacy，liverfibrosisindexandliverfunctionofthetwogroupsbeforeandaftertreatmentwereobserved.ResultsTheeffectiveratewas900%inthecasegroup，whichwassignificantlyhigherthan867%inthecontrolgroup，thedifferencewasstatisticallysignificant（P<0.05）.Aftertreatment，comparedwithbeforetreatment，Thelevelsoftotalbilirubin（TBIL），alanineaminotransferase（ALT），aspartateaminotransferase（AST），layeradhesionprotein（LN），typeⅣcollagen（CIV），hyaluronicacid（HA），andbeforecollagenⅢtype（PCⅢ）weredecreased，whilethelevelsofalbumin（ALB）andcholinesterase（CHE）wereincreasedthedifferencewasstatisticallysignificant（P<0.05）.Aftertreatment，liverfunctionandliverfibrosisindexTBIL，ALT，AST，LN，CIV，HA，PCⅢlevelsdecreased，levelsofALBandCHEincreasedinthetwogroups，thedifferenceswerestatisticallysignificant（P<0.05）.Aftertreatment，comparedwiththecontrolgroup，levelsofTBIL，ALT，AST，LN，CIV，HA，PCⅢdecreased，whilethelevelsofALBandCHEincreasedinthecasegroup，thedifferenceswerestatisticallysignificant（P<0.05）.ConclusionTheeffectofFuzhengHuayuCapsulescombinedwithMagnesiumIsoserateinthetreatmentofchroniclivercirrhosisissignificant.Itcanobviouslyimprovetheliverfunctionandthedegreeofliverf...