基于电子医疗数据的8316例参芎葡萄糖注射液的用药信息分析王晶莹谢雁鸣刘峘张寅贾萍萍庄严摘要目的：基于電子医疗数据的8316例参芎葡萄糖注射液的用药信息，分析在真实世界中参芎葡萄糖注射液临床应用情况，为临床用药提供科学、合理、安全的指导。方法：选取全国19家三甲医院信息系统（HospitalInformationSystem，HIS）中使用参芎葡萄糖注射液的住院患者信息，运用频数统计法、基础数据描述法及关联规则进行分析。结果：在电子医疗数据库所有使用参芎葡萄糖注射液的患者中，大部分患者为45岁以上的中老年人群，占总人数的68.8%;临床多用于冠心病、脑梗死、动脉粥样硬化等缺血性血管疾病，以及炎症性疾病、高血压、骨科疾病等;94.9%的患者给药途径为静脉滴注;82.46%以上的单次用药剂量符合说明书规定的用药范围;用药疗程多数在14d以内;临床最常见联合用药为阿司匹林、疏血通注射液等，合并药理作用多为抗生素类、活血化瘀剂等。结论：参芎葡萄糖注射液使用群体主要以中老年人人群居多;临床用药适应证广泛，存在超说明书适应证用药，合并用药多为药理作用相似的药物，建议药企和临床医生注意并重视患者的受益与风险比，规范临床用药，保障患者用药安全。关键词参芎葡萄糖注射液;电子医疗数据;真实世界;临床应用;关联规则分析;合并用药;用药安全;中成药MedicineAnalysisof8316PatientsUsingShenxiongGlucoseInjectionBasedonElectronicMedicalSystemWANGJingying1，2，XIEYanming1，LIUHuan1，ZHANGYin1，JIAPingping3，ZHUANGYan4（1InstituteofBasicResearchinClinicalMedicine，ChinaAcademyofChineseMedicalSciences，Beijing100872，China;2OphthalmologicHospital，ChinaAcademyofChineseMedicalSciences，Beijing100040，China;3StatisticalInstituteofRenminUniversityofChina，Beijing100872，China;4ThePLANavyGeneralHospital，Beijing100048，China）AbstractObjective：Basedonthemedicationinformationof8316ShenxiongGlucoseInjectioninelectronicmedicalsystem，toanalyzetheclinicalapplicationofShenxiongGlucoseInjectioninrealworld，soastoprovidescientific，reasonableandsafeguidanceforclinicalmedication.Methods：TheinformationofinpatientsusingShenxiongGlucoseInjectioninthehospitalinformationsystem（HIS）of19tertiaryhospitalsnationwidewasselectedandanalyzedusingfrequencystatistics，basicdatadescriptionandassociationrules.Results：OfallthepatientswhousedtheShenxiongGlucoseInjectionintheelectronicmedicaldatabase，mostofthemweremiddle-agedandolderpeopleover45yearsold，accountingfor68.8%ofthetotalnumber;itwasclinicallyusedforcoronaryheartdisease，cerebralinfarction，atherosclerosis，andotherischemicvasculardiseases，aswellasinflammatorydiseases，hypertension，orthopedicdiseases，etc.;94.9%ofpatientswereadministeredintravenously;82.46%ormoreofthesingledosewasinaccordancewiththescopeofmedicationspecifiedintheinstructions;mostofthemedicationcoursewaslessthan14days;themostcommonlyusedclinicaldrugswereaspirin，ShuxuetongInjection，etc.Thecombinedpharmacologicaleffectsweremostlyantibiotics，bloodcirculationandbloodstasisagents.Conclusion：ThepopulationofShenxiongGlucoseInjectionismainlyusedbymiddle-agedandelderlypeople.Theindicationsforclinicalmedicationareextensive，andthereareindicationsforoff-labeluse.Thecombinedmedicationsaremostlydrugswithsimilarpharmacologicaleffects.Itisrecommendedthatpharmaceuticalcompaniesandclinicianspayattentiontobenefittoriskratioofpatients，standardizeclinicalmedication，andensurepatientmedicationsafety.KeywordsShenxiongGlucoseInjection;Electronicmedicaldata;Realworld;Clinicalapplication;Associationrulesanalysis;Drugcombination;Medicationsafety;Chinesepatentmedicine中圖分类号：R259：Adoi：...