---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---临床医学---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---1DeparlnienlofOrthopaedics.FirslAi'filiatedHospital,ZhengzhouUniversity,Zhengzhou450052,HenanProvince,China;'DcparlmcntofGaslrocntcrologj;SecondAtTilialedHospilal,ZhengzhouUniversity,Zhengzhou450014.HenanProvince,ChinaXuJian-zhong^,Doctor.Professor.Chiefphysician,DepartmentofOrthopaedics,FirstAffiliatedHospital,ZhengzhouUniversity,Zhengzhou450052.HenanProvince.Chinatiankekui@163.comReceived:2008-01-16Acccplc止2008-05-29I郑州大学第一附属医院骨科，河南省郑州市450052;彳郑州大学第二附属医院消化内科、河南省郑州市450014许建中男，1963年生，河南省郑州市人，1998年同济医科丸学毕业，博士•教搀主任医师•主要从事关节外科研究。liankekui@l63.com中图分类号：R59322文献标识码:B文章编号:1673$225(2008)424)8307-04人类风湿关节炎滑膜中B74K分子的表达及意义、k许建中1,田科1,刘占举2ExpressionandsignificanceofB7-H1moleculeinthesynoviumofpatientswithrheumatoidarthritisXuJian-zhong—TanKe1,LiuZhan-ji?AbstractBACKGROUND:B7-homolog1(B7-HI)isoneofimportantmembersofcostimulatorymoleculeB7familyandbroadlyinducedinthemajorityofperipheraltissuesaswellaslymphocyte・Someresearcheshavefound(haiB7-HIplaysanimportantroleinautoimmunedisease・B7-H1hasnotbeenreportedinrheumatoidarthritis(RA)patients.OBJECTIVE:ToexploreB7-H1proteinexpressioninhumanRA,andtoanalyzethesignificanceofB7-HIinRAonset.DESIGN,TIMEANDSETTING:ThesuhgroupcontrolobservationwasconductedattheKeyLaboratoryofMolecularBiologyofHenanProvineefromJulvtoDecember2007.PARTICIPANTS:Atotalof51caseswereobtainedtocollectkneejointsynovialtissueduringthearthroscopeoperationattheMicro-InvasiveOrthopaedicsofFirstAffiliatedHospitalofZhengzhouUniversityfromSeptember2004toJuly2007.Therewere35casesofRA,16malecases,19femalecases,aged11-62years,aswellas10casesofosteoarthritis(OA),4malecases,6femalecases,aged45一72yearsold.Thenormalgroupincluded6cases,comprising4malecases,2femalecases,aged14一33yearsold.METHODS:Allthekneejointsynovialtissuewerecollectedfromthetypicallocationintheoperation,confirmedbythetissuePathology.MAINOUTCOMEMEASURES:B7-HIproteinexpressionwasdetectedbyimmunohistoehemistr\^(SABC)inthekneejointtissue.RESULTS:B7-HIinthekneesynovialtissuesof30patients(85.7%)wereobservedpositivelyin35patientswithRA,comparedwith3cases(30.0%)positivein10patientswithOA;whereasicase(16.7%)wereobservedpositivelyof6patientswithnormalsynovialtissues・B7-HIproteinwasmorehigherintheRApatientswithseveresynoviumhyperplasy.CONCLUSION:B7-H1ishighlyexpressedinRApatients,anditmayplayanimportantroleinthepathogenesisofRA.XuJ乙TianK.LiuZJ・ExpressionandsignificanceofB7-H1moleculeinthesynoviumofpatientswithrheumatoidarthritis.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu2008;12(42):8307-8310(China)[www.zglckf.com/zglckf/ejournal/upfiles/08-42/42k-8307(ps).pdf]---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---摘要背景：B7同系物l(B7-HI)分子是共刺激分子B7家族的重要成员，在淋巴细胞及人部分外周组织对以广泛诱导性表达.研究表明，B7-HI在自身免疫性疾病中发挥重要作用，英在人类类风湿关节炎中的作用国内外均无报逍。目的：观察类风湿关节炎关节滑膜组织中B7-HI蛋白的表达,探讨B7-HI在类风湿关节炎发病中的意义。设计、时间、地点：分组对照观察，于2007-07/12在河南省分子生物学重点实验室完成。对象:收集51例标本系200409/200707郑州大学第一附属...