疏补温肾固肠方治疗腹泻型肠易激综合症临床观察和胃肠激素相关性探讨重庆市屮医院重庆400021基金项目：王仁强名医工作室建设项目重庆市卫计委项目:ZY201402031通讯作者：张遂峰重庆市屮医院消化内科［摘要］目的：探讨疏补温肾固肠方治疗腹泻型肠易激综合征的临床疗效和胃肠激素相关性探讨。方法：。选择90例腹泻型IBS患者，随机分为屮药治疗组与西药对照组各45例。屮药治疗组口服疏补温肾固肠方，西药对照组门服匹维溴铵片和马來酸曲美布汀胶囊；疗程为4周。用药前及用药4周后测定监测血清屮胃肠激素(SP、VIP,5羟色胺(5-HT)＞含量。评价两组用药后临床疗效及探讨胃肠激素与疗效相关性。结果：屮药治疗组与西药组治疗腹泻型IBS,在屮医临床症状积分，人便形状改变及生活质量评分等方面效果优于西药组。H肠激素检测方面，治疗前后屮药组与对照组胃肠激素均有卜降，屮药组差异显著，有统计学意义(*P#<0.05)，但对照组差异不明显，无统计学意义(P#>；0.05)o治疗后屮药治疗组与对照组胃肠激素(血管活性肽，P物质，5羟色胺)组间比较，有显著性差异，具有统计学意义(PA<0.05)o说明“疏补温肾固肠方”治疗腹泻型IBS后胃肠激素较治疗前有下降，下降程度较西药对照组明显，有统计学差异。治疗疗效与胃肠激素下降程度有正相关性［关键词］疏补温肾固肠方；胃肠激素；腹泻型肠易激综合征【屮图分类号】R473【文献标识码】A【文章编号】1001-5213(2016)09-0374-02ClinicalObservationontheTreatmentoftheDiarrhea-predominantIrritableBowelSyndromewithshubuwenshenguchangDecoctionandtheCorrelationofGastrointestinalHormonesZhangQiong,ZhangSuiFeng(ChongqingTraditionalChineseMedicineHospital,ChongQing,400044)[Abstract]Objective:TostudytheclinicalefficacyoftheshubuWenshenguchangDecoctionandtheCorrelationofGastrointestinalHormonesinthetreatmentofdiarrheapredominantirritablebowelsyndrome(IBS).Methods:90patientswererandomlydividedintotreatmentgroupandcontrolgroupeach45patients,treatmentgroupwithshubuWenshenguchangDecoction,whilethecontrolgroupusedthePinaveriumBromideTabletsandTrimebutineMaleateCapsules.Thecourseoftreatmentwas4weeks.Determinationofserumlevelsofgastrointestinalhormones(SP,VIP,5serotonin(5-HT))inserumbeforeandafter4weeks.Toevaluatetheclinicaleffectofthetwogroupsaftertreatmentandtoexplorethecorrelationbetweengastrointestinalhormoneandcurativeeffect.Results:BetweenTraditionalChinesemedicinetreatmentgroupandWesternmedicinegrouptreatmentofdiarrheatypeIBS,inChinesemedicineclinicalsymptomscore,stoolshapechangeandqualityoflifescoreandotheraspectsoftheeffectisbetterthanwesternmedicinegroup.InGastrointestinalhormonetestbeforeandaftertreatment,traditionalChinesemedicinegroupandthecontrolgroupofgastrointestinalhormoneweredecreased,thetraditionalChinesemedicinegroupsignificantdifferencewasstatisticallysignificant^*P#<0.05),whiletherewasnosignificantdifference(P#>0.05)inthecontrolgroup•Aftertreatment,thetreatmentgroupandthecontrolgroupofgastrointestinalhormone(vasoactivepeptide,substanceP,5serotonin)groupcomparison,therearesignificantdifferences,withstatisticalsignificance(PA<0.05).Conclusion:ItshowedthatthetreatmentofdiarrheatypeIBSafterthetreatmentofdiarrheatypewasdecreased,andthedegreeofdeclinewassignificantlyhigherthanthatofWesternmedicinecontrolgroup,andtherewassignificantdifferencebetweenthetwogroups.Therewasapositivecorrelationbetweenthetherapeuticeffectandthedecreaseofgastrointestinalhormones.[keyword]shubuWenshenguchangDecoction;Diarrhea-predominantIrritableBowelSyndrome；IBS-D;ClinicalEffect；Gastrointestinalhormone;腹泻型肠易激综合症（IBS）是临床常见的功能性胃肠道疾病，主要临床表现为大便次...
