1311治疗单叶Graves?病的临床分析张怡袁卫红(通讯作者)(昆明医科大学第二附属医院核医学科650101)【摘要】目的分别观察60例经过1311治疗的单叶Graves,病患者和双叶Graves,病患者的临床和随访资料，分析和比较1311治疗单叶Graves,病和双叶Graves,病患者的临床疗效。方法两组患者分别采取1311治疗，治疗后均进行随访观察，通过对比1311治疗后甲状腺缩小程度及治疗疗效的情况，来分析1311治疗单叶Graves,病及双叶Graves,病的临床效果。结果单叶Graves,病1311治疗组：治疗前后甲状腺体积缩小有明显的统计学差异。痊愈43例(71.7%)、好23例(21.7%)、无效4例(6.6%),有效率93.3%,治愈率71.7%。双叶Graves,病1311治疗组：痊愈46例(76.7%)、好转11例(18.3%)、无效3例(5.0%),有效率95.0%，总治愈率76.7%。结论对于单叶Graves,病采取1311治疗，其疗效与1311治疗双叶Graves,病并无明显差异。单叶Graves,病患者，针对甲状腺显像中摄得功能亢进的一叶甲状腺组织进行估重，采取2311治疗，只要治疗剂量得当，坚持个体化治疗方案，加强治疗后随访，均可达到有效的疗效。1311治疗单叶Graves,病，具有有效、安全、经济的优点。【关键词】Graves,病核素治疗1311【中图分类号】R45【文献标识码】A【文章编号】2095-1752(2014)08-0045-03Theclinicalanalysisof1311treatmentinthesingleleafGraves,diseaseZHANGYi,YUANWei-hong.DepartmentofNuclearMedicine,thesecondAffiliatedhospitalofKunmingUniversity^unming650101,ChinaCorrespondingauthor:YUANWei-hong,Emaikyuantianhe@163.com[Abstract]ObjectiveThesingleleafGraves,andthedoubleleavesGraves,patientswereobservedin60casesafter1311treatment,andobservetheclinicalandfollow・updataofpatients,analysisandcomparisonof1311inthetreatmentofthesingleleafGraves,andthedoubleleavesGraves,inpatientswithclinicalefficacy.MethodTwogroupsofpatientswereadopted1311treatment,follow-upobservationwereperformedaftertreatment,comparedwiththe1311treatedthyroidnarrowingeffectdegreeandtreatmentsituation,toanalyzethe1311treatmenteffectinthesingleleafGraves,andthedoubleleavesGraves,.ResultThesingleleafGraves,1311treatmentgroup:beforeandafterthetreatmentofthyroidvolumereductionofthestatisticallysignificantdifference.43caseswerecured(71.7%),improvedin13cases(21.7%),invalid4cases(6.6%),effectiveratewas93.3%,thecureratewas71.7%.ThedoubleleavesGraves,1311treatmentgroup:46caseswerecured(76.7%),improvedin11cases(18.3%),invalid3cases(5%),effectiveratewas95%,thecureratewas76.7%・ConclusionForthesingleleafGraves,diseasetake1311treatment,thecurativeeffectoftreatmentwith1311inthedoubleleavesGraves,diseasewithnotsign讦icantdifferenee.ThesingleleafGraves,patientsinthyroidtissue,thyroidscintigraphyintheuptakefunctionhyperfunctionoftheleafwerereassessed,adoptedthe1311treatment,aslongasthetreatmentdoseproperly,adheretoindividualizedtreatmentplan,strengtheningfollow-upaftertreatment,canachieveeffectiveresults・1311treatmentofGraves,disease,hastheadvantagesofsimple,effective,safe,andeconomy.[Keywords]GravesdisaeseRadionuclidetherapy1311自身免疫性甲状腺疾病(autoimmunethyroiddiseases,AITD)是一组作用于甲状腺细胞和体液免疫反应的综合征，也是一种临床上常见的器官特异性自身免疫性疾病。Graves,病(Graves,disease,GD)是自身免疫性甲状腺疾病中最常见的一种疾病[!•]，也是甲状腺功能亢进症(hyperthyroidism)的最常见疾病类型。GD系指由多种病因导致体内甲状腺激素(thyroidhormonesJH)分泌过多，临床主要表现为甲状腺弥漫性肿大、突眼、神经兴奋性增强及心悸、多汗、体重下降临床确诊的单叶Graves,病组患者60例，男性22例，女性38例，年龄29-61岁,平均年龄38.13岁,病程3丿］—6年，甲状腺重量30—70g彳、等等高代谢症候群等⑵。GD可发生于任何年龄，高发...