收稿日期:2007-11-03录用日期:2007-12-25基金项目:“”国家自然科学基金十五重大项目(No.10490180;科技部973资助项目(No.2006CB705603作者简介:王江雪(1978—,女,博士后;*通讯作者(Correspondingauthor,E-mail:chenchy@nanoctr2008年第3卷第2期,105-113生态毒理学报AsianJournalofEcotoxicologyVol.3,2008No.2,105-113二氧化钛纳米材料的环境健康和生态毒理效应王江雪1,2,李炜1,刘颖1,劳芳1,陈春英1,*,樊瑜波21.国家纳米科学中心-中国科学院高能物理研究所纳米生物效应与安全性联合实验室,北京1000802.北京航空航天大学生物工程系,北京100083---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---摘要:伴随着纳米科技的迅猛发展,各式各样的纳米材料被开发和生产出来,逐步进入到周围环境及生命体中,纳米材料的生物安全性和生态毒理学问题已引起了社会各界的普遍关注.纳米二氧化钛(TiO2因具有良好的光催化特性、耐化学腐蚀性和热稳定性,而被广泛应用于涂料、废水处理、杀菌、化妆品、食品添加剂和生物医用陶瓷材料等与日常生活紧密相关的领域,因此,其将不可避免地进入环境和生态系统中引起相应的生物学效应(毒理学.论文从流行病学调查和实验研究两方面出发,综述了纳米TiO2对生物体(皮肤、肺、肝、肾和脑、细胞(细胞膜、细胞生长和凋亡和生态系统的影响,探讨了其毒性产生的可能机制.希望今后进一步加强对纳米TiO2的环境健康和生态毒性研究,以建立纳米TiO2的环境健康安全暴露评价体系,促进纳米技术的健康、安全和可持续发展.关键词:纳米材料;纳米二氧化钛;环境健康;生态毒理;活性氧:1673-5897(20082-105-09:TB383,X171.5,X18文献标识码:AEnvironmentalHealthandEcotoxicologicalEffectofTitaniumDioxideNanomaterialsWANG激ang-xue1,2,LIWei1,LIUYing1,LAOFang1,CHENChun-ying1,*,FANYu-bo21.LaboratoryforBio-EnvironmentalEffectsofNanomaterialsandNanosafety,NationalCenterforNanoScienceandTechnology-InstituteofHighEnergyPhysics,ChineseAcademyofSciences,Bei激ng1000802.BioengineeringDepartment,BeihangUniversity,Bei激ng100083Received3November2007accepted25December2007---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---Abstract:Withtherapiddevelopmentofnanotechnology,manykindsofnanomatertialsaremanufacturedandusedineachfield.Theytendtoentertheenvironmentandlifesystem.Theproblemofbio-environmentaleffectsofnanomaterialsandnanosafetyhasraisedincreasingconcernsamongmanyscientistsandgovernments.Nanoscaletitaniumdioxide(TiO2,anoncombustibleandodorlesswhitepowder,waswidelyusedinthefieldsofpaints,wastewatertreatment,sterilization,cosmetics,foodadditive,andbio-medicalceramicmaterials,etc.,becauseofitsinherentadvantagesofthephotocatalysis,anticorrosionandhighstability.Therefore,itisunavoidablefornanoscaleTiO2toentertheenvironmentandecologicalsystemandtoinducethepotentialbiologicaleffects(nanotoxicology.Inthispaper,basedonthepastepidemiologyresearchesandlaboratorystudies,theinfluencesofnanoscaleTiO2ontheorganisms(skin,lung,liver,kidneyandbrain,thecells(cellmembrane,cellgrowthandapoptosisandtheecologicalsystemwerereviewed,andthemechanismsforthesetoxicitieswerediscussed.ItisadvisedtoenhancestudiesontheenvironmentalhealthandecotoxicologyofnanoscaleTiO2tohelptoestablishtheevaluationsystemandstandardsofsafeexposurefornanoscaleTiO2,andtopromotethehealthy,safeandpersistentdevelopmentofnanoscienceandnanotechnology.Keywords:nanomaterials;nanoscaleTiO2;environmentalhealth;ecotoxicology;reactiveoxygenspecies生态毒理学报第3卷20世纪80年代末、90年代初发展起来的纳米科技,带动了种类繁多的纳米材料的开发和纳米产品的上市.科学家预言纳米科技的发展将会为社会带来极大的市场和经济效益,促进信息传输、先进材料制造...