替米沙坦联合阿托伐他汀对老年早期糖尿病肾病患者内皮素和血清胱[摘要]目的研究替米沙坦和阿托伐他汀?合治疗对老年早期糖尿病肾病患者内皮素和血清胱抑素C的影响。方法选取该院从2014年6月―2015年6月期间收治的老年早期糖尿病肾病患者90例，按照随机数表法分组，随机分为观察组和对照组，每组45例。观察组病患每天服用替米沙坦片80mg/d和阿托伐他汀钙片10mg/d，疗程12周。对照组病患每天服用替米沙坦片80mg/d。观察治疗前和治疗后的内皮素（ET）、血清胱抑素C（CysC）、平均动脉压（MAP）、低密度脂蛋白胆固醇（LDL-C）、尿白蛋白排出率（UAER）、总胆固醇（TC）、血肌酐（Scr）和甘油三酯（TG）等指标的变化。结果观察组MAP、LDL-C分别降低至（91.78±11.19）mmHg、（2.01±0.75）mmol/L，对照组MAP、LDL-C分别降低至（94.53±13.15）mmHg、（2.69±0.83）mmol/L；观察组Scr、UAER、CysC治疗后分别降低至（59.71±10.39）mol/L，（0.59±0.43）g/24h，（0.76±0.15）mg/L；对照组上述指标分别降低至（40.70±11.33）mol/L，（0.36±0.58）g/24h，（0.49±0.10）mg/L。治疗后两组各项指标均比治疗前明显下降，且观察组较对照组更为明显，差异有统计学意义（P<0.05）。观察组的内皮素（ET）、血清胱抑素C（CysC）分别降低至（51.78±7.59）ng/L、（0.76±0.15）mg/L，其下降程度明显高于对照组（P<0.05）。结论替米沙坦和阿托伐他汀治疗对老年早期糖尿病肾病患者具有改善糖尿病肾病患者状况的作用.[关键词]替米沙坦；阿托伐他汀；联合治疗；老年早期糖尿病肾病患者；内皮素；血清胱抑素C[]R59[文献标识码]A[]1672-4062（2017）02（b）-0025-04EffectofTelmisartanCombinedwithAtorvastatinontheEndothelinandSerumCystatinCofSenilePatientswithEarlyDiabeticNephropathyLILeiDepartmentofPharmacy，SecondHospitalAffiliatedtoChongqingMedicalUniversity，Chongqing，400010China[Abstract]ObjectiveToresearchtheeffectoftelmisartancombinedwithatorvastatinontheendothelinandserumcystatinCofsenilepatientswithearlydiabeticnephropathy.Methods90casesofsenilepatientswithearlydiabeticnephropathyadmittedandtreatedinourhospitalfromJune2014toJune2015wereselectedandrandomlydividedintotwogroupswith45casesineach，theobservationgrouptookthetelmisartantablets80mg/dandatorvastatincalciumtablets10mg/deveryday，andthetreatmentcoursewas12weeks，thecontrolgrouptookthetelmisartantablets80mg/deveryday，andthechangesofET，CysC，MAP，LDL-C，UAER，TC，ScrandTGbeforeandaftertreatmentwereobserved.ResultsTheMAPandLDL-Crespectivelydecreasedtothe（91.78±11.19）mmHgand（2.01±0.75）mmol/Lintheobservationgroupand（94.5313.15）mmHgand（2.69±0.83）mmol/Linthecontrolgroup，aftertreatment，theScr，UAERandCysCintheobservationgroupaftertreatmentdecreasedto（59.71±10.39）mol/L，（0.59±0.43）g/24h，（0.76±0.15）mg/Linthecontrolgroupand（40.70±11.33）mol/L，（0.36±0.58）g/24h，（0.49±.10）mg/Linthecontrolgroup，andtheaboveindexesofthetwogroupsbeforeandaftertreatmentwereobviouslydecreased，andthedecreasedegreeintheobservationgroupwasmoreobviousthanthatinthecontrolgroup，andthedifferencewasstatisticallysignificant（P<0.05），andtheETandCysCintheobservationgrouprespectivelydecreasedtothe（51.78±7.59）ng/Land（0.76±0.15）mg/L，andthedecreasedegreewasobviouslyhigherthanthatinthecontrolgroup（P<0.05）.ConclusionTelmisartancombinedwithatorvastatinintreatmentofsenilepatientswithearlydiabeticnephropathycanimprovethepatients’diseaseconditions.[Keywords]Telmisartan；Atorvastatin；Combinedtreatment；Senilepatientswithearlydiabeticnephropathy；Endothelin；SerumcystatinC糖尿病肾病（diabeticnephropathy，DN）是糖尿病全身微血管病性合并症之一，其发生会诱发其他病...