灯盏细辛注射液联合西药常规治疗瘀证型高血压病的临床疗效与安全性分析【摘要】目的：研究灯盏细辛注射液联合西药常规治疗瘀证型高血压的临床疗效与安全性。方法：选取2013年2月-2014年2月笔者所在医院收治的瘀证型高血压患者110例，按照随机数字表法将其分为研究组和对照组，每组55例，研究组给予灯盏细辛注射液联合西药常规治疗，对照组给予西药常规治疗，比较两组治疗前后血压值、瘀证积分、临床症状积分、血液流变学指标、不良反应。结果：治疗后研究组收缩压、舒张压分别为(129.8土0.3)mmHg>(71.8±2.1)mmHg,显著优于对照组，两组比较差异均有统计学意义(t二10.035、9.585,P二0.024、0.031)；治疗后研究组血瘀证积分和临床症状积分分别为(19・2±0.3)分、(2.4±0.7)分，显著优于对照组，两组比较差异均有统计学意义(t二9.793、9.069,卩二0.027、0.032)；治疗后研究组全血黏度、血浆黏度、红细胞压积及红细胞聚集指数分别为(3.69±0.02)mPa?s>(1.58土0.01)mPa?s>(0.33±0.02)%和(3.36±0・04),显著优于对照组，两组比较差异均有统计学意义(t=10.021、10.173、9.896、9.372,P=0.024、0.026、0.033、0.036)；两组不良反应发生率比较，差异无统计学意义(字2=5.072,P二0.083)。结论：灯盏细辛注射液联合西药常规治疗具有较好的降压效果，能显著改善患者的瘀证积分和临床症状积分，改善患者的血流变学指标。【关键词】灯盏细辛注射液；瘀证型；高血压；安全性中图分类号R544.1文献标识码B文章编号1674-6805(2015)34-0022-03[Abstract]Objective：TostudytheclinicalefficacyandsafetyanalysisofFleabaneInjectioncombinedwithconventionalmedicineinthetreatmentofstasishypertension・Method:110caseswithstasishypertensionwereselectedinourhospitaifromFebruary2013toFebruary2014,theyweredividedintothestudygroupandthecontrolgroupaccordingtoarandomnumbertable,55casesineachgroup.ThepatientsofthestudygroupweregivenFleabaneTnjectioncombinedwithconventionalmedicineandthepatientsofthecontrolgroupweretreatedwithconventionalmedicine.Thebloodpressure,bloodstasisintegration,clinicalsymptomscoreaftertreatmentandhemorheology,adversereactionsoftwogroupswerecompared.Result:Thesystoliebloodpressure,diastolicbloodpressureofthestudygroupaftertreatmentwere(129.8±0.3),(71・8±2.1)mmIlgsignificantlybetterthanthoseofthecontrolgroup,thedifferenceswerestatisticaJlysignificant(t二10.035,9.585,P二0.024,0.031).Thestasisscoreandclinicalsymptomscoreofthestudygroupaftertreatmentwere(19・2±0.3),(2.4±0・7)pointssignificantlybetterthanthoseofthecontrolgroup,thedifferenceswerestatisticallysignificant(t二9.793,9.069,P二0.027,0.032)•Thewholebloodviscosity,plasmaviscosity,hematocritandredbloodcellaggregationindexofthestudygroupaftertreatment.were(3.69±0.02)niPa?s,(1.58±0.01)mPa?s,(0.33±0.02)%and(3.36+0.04)significantlybetterthanthoseofthecontrolgroup,thedifferenceswerestatisticallysignificant(t二10.021，10.173,9.896,9.372,P二0.024,0.026,0.033,0.036).Theadversereactionsoftwogroupshadnostatisticallysignificant(字2=5.072,P二0.083)・Conclusion：FleabaneInjectioncombinedwithconventionalwesternmedicinehasabetterantihypertensiveeffect,cansignificantlyimprovethepatientsbloodstasisIntegrationandclinicalsymptomscore,improvethepatient?sbloodrheologyindex・[Keywords]FleabaneInjection；Stasistype；Hypertension；SafetyFirst-author'saddress:DongfengCountyXiaosipingTownYimianshanHospital,Dongfeng136312,Chinadoi：10.14033/j.cnki.cfmr.2015.34.008高血压是临床上的常见病和多发病，是多种心脑血管疾病的危险因素。近年来，高血压的发病率呈逐年上升的趋势，严重威胁着人民的健康[1]。现阶段治疗高血压的方法较多，但是对临床症状的改善和长期的预后效果不尽人意，中医...