血清降钙素原在肺结核抗结核治疗疗效评估中的价值［摘要］目的研究血清降钙索原在肺结核抗结核治疗疗效评估中的价值方法选择2012年1月〜2013年1月本科诊治的肺结核患者为研究对象（观察组），以同期未行抗结核治疗的肺结核患者为对照（对照组）,比较两组患者治疗前后血清降钙素原的水平并分析不同水平降钙索原抗结核治疗疗效羌异。结果观察组和对照组肺结核患者治疗前血清降钙素原差异无统计学意义，观察组患者治疗后1个月、3个月和6个月血清降钙素原显著降低（卩〈0.05）,对照组治疗1个月、3个月和6个月血清降钙素原升高，观察组肺结核患者治疗1个月、3个月和6个月血清降钙素原均显著低于对照组（P〈0.05）。治疗前降钙素原水平显著升高、轻度升高和正常患者治愈率依次降低（P〈0・05）。结论肺结核患者血清降钙素原可作为其抗结核治疗疗效评估的标志物。［关键词］肺结核；降钙素原；疗效［中图分类号］R521［文献标识码］B［文章编号］2095-0616（2013）15-152-02Valueofserumprocalcitonininanti-tuberculosistherapeuticeffectevaluationfortuberculosisXULiJINXueDepartmentofInfectiousDisease,theNo.1People'sHospitalofGuangshui,Guangshui432700,China[Abstract]ObjectiveTostudythevalueofserumprocalcitonininanti-tuberculosistherapeuticeffectevaluationfortuberculosis.MethodsThepatientswithtuberculosistreatedwithanti-tuberculosistherapyinourdepartmentfromJanuary2012toJanuary2013wereselectedastheobservationgroup,whilenoanti-tuberculosistreatmentpatientswithtuberculosisduringthesameperiodwereselectedasthecontrolgroup・Thelevelofserumprocalcitonininthetwogroupsbeforeandafterthetreatinentwerecomparedandtheanti-tuberculosistherapeuticeffectdifferenceofdifferentlevelsofprocalcitoninwereanalyzed.ResultsTherewasnotsignificantdifferenceinthelevelofserumprocalcitoninbeforethetreatmentbetweentheobservationgroupandthecontrolgroup.Thelevelsofserumprocalcitoninintheobservationgroupafterthetreatmentof1month,3monthsand6monthsdecreasedsignificantly(P<0.05),whilethelevelsofserumprocalcitonininthecontrolgroupafterthetreatmentof1month,3monthsand6monthsincreased,andthelevelsofserumprocalcitoninintheobservationgroupafterthetreatment,of1month,3monthsand6monthsweresignificantly1owerthanthoseinthecontrolgroup(P<0.05)・Thecureratesofpatientswithsignificantelevated,mildlyelevatedandnormallevelofserumprocalcitoninbeforethetreatmentreducedinturn(1X0.05)•ConclusionSerumprocalcitonininpatientswithtuberculosiscanasasignofanti一tuberculosistherapeuticeffectevaluation.［Keywords］Tuberculosis；Procalcitonin；Curativeeffect肺结核是一种细胞介导的特界性免疫炎症，细胞免疫在其发生、发展及转归中扮演决定作用［1］。降钙素原是甲状腺滤泡旁C细胞分泌的糖蛋白，在炎症反应时显著升高，在炎症性疾病诊断、病情及预后评佔中扮演重要作用［2］。研究表明，活动性肺结核和肺结核伴感染患者血清降钙素原均显著高于健康人［3］,但0前在降钙素原与抗结核疗效方血尚无相关研究。木研究检测结核病患者治疗前后血清降钙素原改变，分析其与疗效的关系，研究其在肺结核抗结核治疗疗效评估中的价值。