基于数据挖掘中药复方治疗糖尿病用药规律探究王世长李靖彭博高彤彤张婧张海力Summary目的：基于數据挖掘技术探究中药复方治疗糖尿病的用药规律。方法：以中国方剂数据库为检索库，检索治疗“消渴”“脾瘅”“消瘅”“消渴病”“肺消”“膈消”“消中”“肾消”的中药方剂，建立中药复方治疗糖尿病方剂数据库，并采用Excel、SPSS22.0软件进行频数及频率分析、因子分析、聚类分析等，进而对中药复方用药规律进行定量、定性分析并探讨其可能机制。结果：中药复方治疗糖尿病涉及方剂605首，中药426味，高频中药93味，甘草、麦冬、人参、茯苓、天花粉、黄连等较为常用;补气药、清热泻火药、清热燥湿药、补阴药最常选用;四气以寒、平、微寒、温、微温，五味以甘、苦、辛、微苦，归经以归肺经、脾经、心经、胃经、肾经较常选用;因子分析最后提取了10个公因子，累积贡献率达33.33%，其中补虚以益气养阴、补血生津等治法为主;泻实以清热泻火、清热燥湿、利水消肿、清热凉血等为主，以扶正祛邪为主要治则;聚类分析结果得到10个药对或药组。结论：临床治疗糖尿病疾病多从肺、脾、胃、心、肾入手，以扶正祛邪为主要治则，多采用滋阴养血、益气健脾结合清热泻火、清热燥湿、行气活血等方法选取相应中药组方治疗。Key中药复方;糖尿病;数据挖掘;频数分析;因子分析;聚类分析AbstractObjective：ToexplorethemedicationrulesoftraditionalChinesemedicine（TCM）compoundprescriptionofdiabetesmellitus（DM）basedondataminingtechnology.Methods：TakingtheChineseprescriptiondatabaseastheretrievaldatabase，thetraditionalChinesemedicine（TCM）prescriptionfortreating“消渴”，“脾瘅”，“消瘅”，“消渴病”，“肺消”，“膈消”，“消中”and“肾消”wassearchedtoestablishprescriptiondatabaseofTCMcompoundprescriptioninthetreatmentofDM，andExcel，SPSS22softwarewasusedforfrequencyanalysis，factoranalysis，clusteranalysisetc.，andthenthequantitativeandqualitativeanalysisoftheregularityofTCMcompoundmedicationwasconductedanditspossiblemechanismwasdiscussed.Results：TCMcompoundprescriptionofDMinvolves605prescriptions，426kindsofChinesemedicine，93flavorsofhighfrequencyherbs.RadixGlycyrrhizae，RadixOphiopogonis，RadixGinseng，Poria，RadixTrichosanthis，RhizomaCoptidisarecommonlyused;Qi-tonifyingherbs，heat-clearingandfire-purgingherbs，heat-clearinganddampness-dryingherbs，yin-tonifyingherbsaremostcommonlyused;Cold，neutral，lightcold，warm，andlightwarmoffourpropertiesofdrugs;Sweet，bitter，pungentandslightlybitteroffiveflavors;Lung，spleen，heart，stomachandkidneychannelsofchanneltropismweremostcommonlychosen;Totally10commonfactorswereextractedfromthefactoranalysis，andthecumulativecontributionratewas33.33%，amongthem，tonifyingdeficiencymainlyreliedoninvigoratingqiandyin，replenishingbloodandpromotingbodyfluid，andpurgingexcessmainlyreliedonclearingheatandfire，clearingheatanddryingdampness，inducingdiuresisforremovingedema，clearingheatandcoolingblood，etc.，andthemaintreatmentprincipleswasstrengtheningthevitalqiandeliminatingpathogenicfactors;totally10druggroupswereobtainedbyclusteranalysis.Conclusion：ClinicaltreatmentofDMismostlyfromthelung，spleenandstomach，heartandkidney，andreinforcingthevitalqiandeliminatethepathogenicfactorsisthemaintreatmentprinciple.Nourishingyinandtonifyingblood，invigoratingqiandinvigoratingspleencombinedwithclearingheatandpurgingfire，clearingheatanddryingdampness，promotingqiandactivatingbloodcirculationandothermethodsweremostlyusedforselectingthecorrespondingTCMprescriptiontotreatthedisease.KeyWordsTCMcompoundprescription;Diabetesmellitus;Datamining;Frequencyanalysis;Factoranal...