AntiplateletdrugsofdifferenttypesofcoronarylesionsinpatientswithunstableanginaplateletfunctionPaperstowritenetwork:Author:ChengRufeng,MILITARY,ChengHexiang[Keywords]unstableangina[Abstract]AIM:TocomparetheeffectsofaspirinandclopidogrelonplateletsbetweenpatientswithunstableanginapectorisoftypeAandthosewithunstableanginapectorisoftypeBcoronarylesions,whoallhadreceivedcoronarystenting.METHODS:AccordingtoACC/AHAclassification,typeAlesionunstableanginapectorispatients(groupA,n=32)andtypeBlesionsunstableanginapectorispatients(groupB,n=30)wereincludedinthestudy.Allthepatientsunderwentpercutenoustransluminalcoronaryangioplastyandcoronarystenting.Theytookclopidogrelloadingdosage300mgandaspirin300mgnolessthan2hpreoperationandpostoperation75mgclopidogreland300mgaspirindaily.Peripheralvenousbloodwascollectedbefore,2haftertakingthemedicine,and6h,24handonemonth1afterangioplasty,andplasmasampleswereanalyzedforTXB2,GMP140andMPARbyenzymelinkedimmunoadsorbentassay(ELISA)andimmuneturbidimetryrespectively.RESULTS:①At2haftertakingmedicine,thelevelsoftheaboveindexesingroupAandgroupBweresignificantlylowerthanthosebeforetakingmedicine.②At6hand24hafterangioplasty,thelevelsofabovethethreeindexesinbothgroupsweresignificantlyhigherthanthosebeforeand2haftertakingmedicine.Nosignificantdifferencewasfoundat2haftertakingmedicineandatonemonthafterangioplasty.ButingroupB,thelevelsofTXB2andGMP140werestillsignificantlyhigherthanthoseat2haftertakingmedicine.③Beforeand2haftertakingmedicine,at6h,24handonemonthafterangioplasty,thelevelsoftheaboveindexesingroupBweresignificantlyhigherthanthoseingroupAexceptforMPARat2haftertakingmedicine.CONCLUSION:RoutineantiplatelettherapycaneffectivelyinhibitplateletactivationinunstableanginapectorispatientswithtypeAcoronarylesions,butisnotveryeffectiveintypeBcoronarylesionpatients.2[Keywords]unstableangina;TXB2;GMP140;MPAR[Abstract]Objective:Toinvestigatetheaspirinplusclopidogrel(Plavixdifferenttypesofcoronaryarterydiseaseinpatientswithunstableangina,percutaneoustransluminalcoronaryangioplasty(PTCAplusstentingbeforesurgery,thedegreeofinhibitionofplateletactivity.Methods:Alesionsofcoronaryheartdiseaseinpatientswithunstableangina,32cases,30casesoftypeBlesions,allreceivingPTCAplusstenting,atleast2hbeforesurgerytakingaspirin300mgfollowedby300mg/d,theloadingdoseclopidogrelGray300mg,followedby75mg,1/drespectivelymedicationaftermedication,2h,aftersurgeryfor6h,24hand1mocubitalveinbloodcollection.turbidimetricmethoddeterminationofmaximumplateletaggregationrate(MPARenzymelinkedimmunosorbentDeterminationofplateletgranulemembraneglycoprotein(GMP140)andthromboxaneB2(TXB2concentration.Results:①Agroup,Bgroupmedicationfor2hTXB2,GMP140MPARcomparedwithmedicationdecreasedsignificantly(P<0.05;②groupABgroupafter6h,24hindicatorscomparedwithpreoperativeand2hafterdosingwassignificantlyhigher3(P<0.05,1moAgroupofthreeindicatorswithmedicationafter2hnosignificantdifference(P>0.05,thegroupBGMP140TXB2stillhigherthanmedicationafter2h(P<0.05,③beforetakingthedrugafter6h,24hand1momorethan3indicatorsofgroupBweresignificantlyhigherthaningroupA(P<0.05;medication2hafteronlyGMP140andTXB2BgroupwassignificantlyhigherthanthatingroupAConclusion:theconventionaldoseaspirinclopidogrelcaneffectivelyinhibitplateletactivationofpatientswithtypeAlesions,butinadequateanti-plateleteffectfortypeBlesions.[Words]unstableang...