T2mapping技术在腰椎间盘磁共振成像中的应用马庆联孙琦(通讯作者)董敏俊陶晓峰(上海交通大学医学院附属第九人民医院放射科上海200011)【摘要】目的:探讨T2*mapping成像技术在腰椎间盘磁共振成像(MagneticResonanceimaging,MRI)中的应用研究。方法：随机选取来我院行腰椎间盘MR扫描患者40名,L1/L2-L5/S1椎间盘行常规斜矢状位(ObliqueSaggital,OSag)T2WI和T2*mapping扫描，并在各个椎间盘髓核内放置感兴趣区(RegionOfInterest,R0I)；测量T2WI信号值和T2*值，并统计两者的差异。结果：L1/2椎间盘T2WISI值及丁2*值最高，Ll/2-L5/S1椎间盘两值均随其解剖位置的降低而降低；按Pfirrmann’s分级法将各椎间盘分I-V级，T2WISI值与T2*值均随I--V级级别升高而信号逐渐降低，且丁2*值较同组T2WISI值大幅降低，L1/L2椎间盘第1级与第II级值的差距较其他组别大。结论：髓核了2*弛豫时间值的空间变化可能量化反映椎间盘退变早期髓核的生化状态；应用T2*mapping技术可能对椎间盘早期退变进行前瞻性定量评价。【关键词】磁井振成像；腰椎椎间盘退变；T2*mapping技术【中图分类号1R681.5【文献标识码】B【文章编号】1003-5028(2015)8-0673-02ApplicationoftheT2*mappingtechniqueintheMRimagingofthelumbardiscMaQing-lian,SunQi,DongMin-jun,TaoXiao-feng【Abstract】Purpose:ToinvestigatetheapplicationoftheT2*mappingtechniqueofthelumbardiscintheMagneticResonanceimaging(MRI).Methods:Wecollectedrandomly40patientswhounderwenttheroutineMRscanningofthelumbarintervertebraldiscinourhospitalretrospectively.Allthepatientsdidn’tsufferfromthehistoryofoperation,placedintotheinternalfixationandhavetheMRscanningcontraindication.TheT2WIandtheT2*mappingsequence(ObliqueSaggital)werescannedbyMRI,whichwasmeasuredbythemeansofsettinguptheregionofinterest(ROI)ofthenucleuspulposusfromL1/L2toL5/S1intheintervertebraldiscsimultaneously.Andthen,twonumericalvaluesofthenucleuspulposus(NP)inthelumbarintervertebraldiscwereanalyzedandcompared.Results:TheT2WISIvalueandtheT2*valueoftheL1/L2intervertebraldiscwerethehighest,andthevaluesoftheT2WISIandtheT2*werereducedalongwiththedecreasedanatomicallocationfromL1/L2toL5/S1intervertebraldisc.AccordingtothePfirrmann’sgradingmethod,allofthelumbarintervertebraldiscsweredividedintoI-Vgrading,andallthevaluesoftheT2WISIandtheT2*weredecreasedgraduallyalongwiththeincreasinggradingfromItoVgrading.Moreover,thevalueoftheT2*waslowerthanthevalueoftheT2WISIinthesamegroup.Amongthem,thedifferenceofT2*valuebetweenIgradingandVgradingintheL1/L2lumbarintervertebraldiscwaslargerthanothergradinggroups.Conclusion:TheT2*mappingtechnique,whichthespatialvariationoftheT2*relaxationtimevaluesintheNPcouldreflecttheearlybiochemicalstateoftheintervertebraldiscdegeneration,couldprovidetheprospectiveevaluationandearlyimagingevidenceforthediagnosisoflumbarintervertebraldiscdegeneration.【Keywords】magneticresonanceimaging；lumbarintervertebraldiscdegeneration；T2*mappingtechnologyDepartmentofRadiology,ShanghaiNinthPeople’sHospital,ShanghaiJiaoTongUniversitySchoolofMedicineAddress:639ZhizaojuRd.,Shanghai200011,P.R.C.AddressCorrespondencetoSunQi(E-mail:xiaosi-qiqi@yeah.net)腰背痛给患者带来极大的困扰，并且严重影响了人们的日常生活和工作。近年来，研宄［1】已发现临床上的腰痛多与椎间盘退变的发生与发展有关。如何准确地量化评估腰椎间盘的退变程度，尤其是对腰椎间盘早期退变进行客观评估奋着重要临床意义。磁共振(magneticresonanceimaging，MRI)具存多参数、多方位、多序列以及软组织分辨力高的特点，常常用于评估椎间盘退行性变的中、晚期改变［2］。随着定量性MRI技术的发展，量化MRI方法可以更加精确、客观、无创的...