急性哮喘气道炎症表型与激素治疗反应性的关系李志伟，马千里，张巧，曾兰，程晓明，林科雄，王长征(400037重庆，第三军医大学新桥医院全军呼吸内科研究所)［摘要］H的研究急性哮喘气道炎症表型与激素治疗反应性的关系。方法采用回顾性的方法对85例急性哮喘患者的诱导痰炎症细胞进行分类，并研究了不同气道细胞炎症表型与患者使用全身激索剂量、天数等的关系。结果根据患者诱导痰炎症细胞分类的不同，将患者分为四组：嗜酸细胞组(31.8%,27/85)和中性粒细胞组(30.6%,26/85)、混合细胞组(16.4%,14/85)和寡细胞组(21.2%,18/85)。各组患者在性别和是否吸烟方而无统计学差界，但嗜酸细胞组患者严重程度与混合细胞组有统计学差异(尺0.05)。嗜酸细胞纽全身激索使川剂量及天数显苦少丁-寡细胞和混合细胞组(尺0.05)。同期患者使用吸入激索剂最使用吸入激索天数方面，混合细胞组显著多于嗜酸细胞组(A0.05)。中性粒细胞组吸入激索剂量显著少于混介细胞组(X0.05),而嗜酸细胞组患者住院夭数显著少于混合性细胞组(A0.05)o其余各组间在全身激素使用剂量及夭数、吸入激素使用剂虽及夭数、住院时间比较无统计学差异(00.05)。结论不同炎症表型对激素的治疗反应性可能存在差开。不同炎症表型对治疗的反应性差界可能给临床带来重要的指导意义。［关键词］诱导痰；哮喘急性加重；气道炎症；激索RelationshipbetweenthephenotypesofairwayinflammationandtheresponsestocorticosteroidtreatmentinacuteasthmaLiZhiwei,MaQianli,ZhangQiao,ZengLan,ChengXiaoming,LinKexiong,WangChangzheng*(InstituteofRespiratoryDiseases,XinqiaoHospital,ThirdMilitaryMedicalUniversity.Chongqing,400037、China.)［Abstract］ObjectiveToinvestigatetherelationshipbetweenthephenotypesofairwayinflammationandtheresponsestocorticosteroidtreatmentinacuteasthma.MethodsTheinflammatorycellsoftheinducedsputumobtainedfrom85patientswithacuteasthmawereclassified,andtherelationshipbetweenthephenotypesofairwayinflammationandthedoseofsystemiccorticosteroidandthetreatmenttimeofcorticosteroidtreatmentwasretrospectivelyanalyzedinthesepatients.ResultsAccordingtotheclassificationofthesputumcells,the85acuteasthmaticpatientsweredividedintofourgroupsincludinganeosinophilgroup(31.8%,27/85),aneutrophilgroup(30.6%,26/85),amixedcellgroup(16.4%,14/85)andapauci-granulocytegroup(21.2%,18/85).Therewasnosignificantdifferenceofsexandsmokingamongthefourgroups(P>0・05),buttheseverityofacuteasthmaoftheeosinophilgroupwassignificantlydifferentfromthatofthemixedcellgroup(Pv0.05)・Thetotaldoseofsystemiccorticosteroidandthetreatmenttimeweresignificantlylessintheeosinophilgroupthaninthemixedcellgroupandthepauci-granulocytegroup(P<0.05),whilethetotaldoseofinhaledcorticosteroidandthetreatmenttimeweresignificantlymoreinthemixedcellgroupthanintheeosinophilgroup(P<0.05).Thetotaldoseofinhaledcorticosteroidinthemixedcellgroupwassignificantlyhigherthanthatoftheneutrophilgroup,whilethehospitalizationtimeofthemixedcellgroupwassignificantlylongerthanthatoftheeosinophilgroup(P<0.05).Therewasnosignificantdifferenceofthedoseandtreatmenttimeofsystemicandinhaledcorticosteroidandthehospitalizationtimeamongtherestofthegroups(P>().()5)・ConclusionDifferentphenotypesofairwayinflammationmayhavedifferentresponsestocorticosteroidtreatmentinacuteasthma,whichmayprovideimportantclinicalimplicationsforthetreatmentofacuteasthma・^CorrespondingAuthor:WangChangzheng,E-mail:czvvang@netease.com---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---众所周知，哮喘是一-种慢性气道炎症性疾患。一直以來，都认为以嗜酸性...