上海口腔医学2014年2月第23卷第1期ShanghaiJournalofStomatologyVol・23No.1Fcbruary,2()14［文章编号］1006-7248(2014)01-0103-04伐昔洛韦联合龈下刮治和根面平整治疗重度慢性牙周炎的疗效观察付永伟，李向新，龚永庆，徐宏志（连云港市第一人民医院口腔科，江苏连云港222002）［摘要］目的：评价伐昔洛韦联合龈下刮治和根而平整治疗重度慢性牙周炎的临床疗效。方法：将59例重度慢性牙周灸患者随机分为对照治疗组(n=29)和干预治疗纽(n=30)o对所有患者进行口腔卫生指导、龈上洁治和抛光。龈上洁治后1周内，干预治疗组口服伐昔洛韦，对照治疗口服安慰剂。2组患者均在龈上洁治】周后，于48h内分2次完成龈下刮治和根面平整。在基线点以及牙周治疗后2、6个月时对所有患者进行牙周检査。采用SPSS17.0软件包对数据进行统计学分析。结果：在基线时，对照治疗组与干预治疗组间牙周指标的差异均无显著性。治疗后2个月和6个月，干预治疗纽探诊fl!血(bleedingonprobing,BOP)阳性位点百分比减少值、牙周探诊深度(probingdepth,PD)>4mm的位点百分比减少值和PD的减少值均显著高于对照治疗纽(PV0.05),干预治疗纽临床附着水平(CliniCalattachmentlevel,CAL)的减少值与对照治疗组比较虽有所升為，但差异无显著性。结论：应用伐昔洛韦作为重度慢性牙周炎机械治疗的辅助治疗，可显著提高临床疗效0［关键词］牙周炎；伐昔洛韦；抗病W治疗；随机对照试验［中图分类号］R781.4［文献标志码］AValacyclovirasanadjuncttotiill-mouthscalingandrootplaningofadvancedchronicperiodontitis:arandomizedclinicaltrailFUYong-wei,LIXiang-xin,GONGYong-qing,XUHong-zhi.(DepartmentofStomatology,TheFirstPeople'sHospitalofLianyungangCity.Lianyungang222002,JiangsuProvinee,China)［Abstract］PURPOSE:TheaimofthisstudywastoevaluatetheCliniCalbenefitofvalaCyCIovirwhenperformingfullmouthperiodontaldebridementinpatientswithadvanCedChroniCperiodontitis・METHODS:Fifty-ninepatientswithadvanCedChroniCperiodontitiswererandomlyassignedintoControl-treatmentgroup(n=29)andintensive-treatmentgroup(n=30).AllpatientsweregiveninstmCtionsofbasicoralhygieneandastandardCyClcofsupragingivalmcC'haniCalsCalingandpolishing.Patientsintheintensive-treatmentgroupreCeivedoralvalaCyCIovirfor1week,whilepatientsintheControl-treatmentgrouprcCcivcdplaCcbo.Thereafter,patientsinbothgroupsunderwenthill-mouthintensiveremovalofsubgingivaldentalplaquebiofilmswiththeuseofsCalingandrootplaningwithin48hours.Periodontalparameterswereevaluatedbeforetreatmentand2or6monthsaftertreatment.ThedatawasstatisticallyanalyzedusingSPSS17.0softwarepackage・RESULTS:NosigniflCantdifferenceinCliniCalparameterswasnotedbeforetreatment.2and6monthsaftertreatment,themeanpercentagereductionofsiteswithBOPandPD>4mmweresignificantlyhigherintheintensive-treatmentgroupthanintheControl-treatmentgroup(P<0.05).Similarly,patientsintheintensive-treatmentgrouphadhighermeanPDreductionthanthoseintheControl-treatmentgroup2months(P<0.()5)and6monthsaftertherapy(P<0.05).However,themeanvaluesofCALreductionwereslightlyandnotsignificantlyhigherintheintensive-treatmentgroupthanintheControl-trealnientgroupaftertherapy.CONCLUSIONS:ItmaybeConcludedthatvalaCyCIovirsignificantlyimprovesCliniCalresultsofbill・mouthnon-surgiCalperiodontaldebridementinadvanCedChroniCperiodontitis.［Keywords］Periodontitis;V'alaCyClovir;Antiviraltreatment;RandomizedControlledtrialShanghaiJStomatol,2014,23(1):103-106・［收稿日期］2013-06-27；［修回日期］2013-08-05［作者简介］付永伟<19800，男•硕士研究生，主治医师［通信作者］付永伟»Tel:0518-85467474>E-mail：tuyongweivip@sina.CotnC2014年版权归《上海口腔医学》编辑部所有近年来，在牙周病的病因...