非小细胞肺癌高钙血症多学科综合治疗近期疗效观察摘要：目的探？以化疗为基础，联合放射性核素及双磷酸盐的综合治疗手段治疗肺癌骨转移性高钙血症的近期临床疗效。方法采用非小细胞肺癌含钳化疗方案联合放射性核素89SrCL2及哇来麟酸治疗33例肺癌骨转移所导致的高钙血症，动态观察患者血钙浓度变化。结果33例患者高钙血症有效缓解23例，总有效缓解率为69.7%；化疗有效组12例，高钙血症有效缓解11例，缓解率为91.7%,化疗无效组21例，高钙血症有效缓解12例，缓解率为57.1%,化疗有效组高钙血症的有效缓解率高于化疗无效组，差异有统计学意义(X2二4.309,P二0.042)。化疗有效组及无效组高钙血症有效缓解的平均持续时间分别为(82.2±12.4)d及(68.5±7.6)d,差异有统计学意义(t二3.007,P二0.011)。结论化疗联合放射性核素及双磷酸盐的综合治疗手段可以有效缓解部分非小细胞肺癌骨转移性高钙血症，其中化疗有效患者接受该治疗手段显示出更好的疗效。关键词：关键词非小细胞肺癌；恶性高钙血症；综合治疗中图分类号：R730.53文献标识码：AHort-termEfficacyObservationofMultidisciplinarySyntheticTherapyofNon-small-cellLungCancerwithHypercalcemiaWANGQiongl,DENGYong-Jun2,SHIYun-Fei3,LIUHuang-Pcng2,LIJue2(1.DepartmentofPharmacy,ThePeople，sHospitalofLuopingCounty,Luoping655800,Yunnan,China；2.DepartmentofThoracicSurgery,TheFourthAffiliatedHospitalofKunmingMedicalUniversity,Kunming650017,Yunnan,Chirm；3.DepartmentofThoracicSurgery,TheFirstAffiliatedHospitalofKunmingMedicalUniversity,Kunming6500327,Yunnan,China)Abstract：ObjectiveToexploretheshort-temiclinicaleffectsofmultidisciplinarysynthetictherapyofchemotherapycombinedwithradionuclideandbisphosphonatesintreatmenton33non-small-celllungcancerpatientswithhypercalcemia・Methods33non-small-celllungcancerpatientswithhypercalcemiaweretreatedwithplatinum-basedchemotherapycombinedwithradionuclide89SrCL2andzoledronicacidbythesupportofGranulocyte-macrophagecolony-stimulatingfactor(GM-CSF)•Thelevelofblood-calciumwasobservedregularlyandtheefficacywasevaluated.ResultsHypercalcemiain23caseswerefoundtobealleviatedeffectivelyandthealleviationratewas69.7%,thereinto,11caseshappenedin12chemotherapy-effectivepatients(chemotherapy-effectivegroup)andtheother12casesoccurredin21chemotherapy-ineffectivepatients(chemotherapy-ineffectivegroup)•Theeffectivealleviationrateofhypercalcemiainchemotherapy-ineffectivegroup,thedifferencewasstatisticallysignificant(91.7%vs・57.1%,x2=4.309,P=0.042)・Theaveragedurationofthealleviationofhypercalcemiaeffectivelyinchemotherapy-effectivegroupwasIongerthanthatinchemotherapy-ineffectivegroup(82.2±12.4dvs.68.5±7・6d,t=3・007,P=0.Oil).ConelusionMultidisciplinarysynthetictherapyofchemotherapycombinedwithradionuclideandbisphosphonatescouldeffectivelyalleviatedpartpatientswithmalignanthypercalcemia.Itseemedthatthesepatientswhoweresensitivetochemotherapyshowedbetterclinicaleffect・Keywords:Non-smal1celllungcancer；Malignanthypercalcemia；Combinodtherapy骨转移是晚期恶性肿瘤患者常见的并发症Z-,其屮部分骨转移患者常合并高钙血症，据文献报告其发生率为5%〜10%[1],多见于肺癌、乳腺癌、多发性骨髓瘤、肾癌、前列腺癌等肿瘤。摆在肿瘤医师面前的一个难题是如何有效地缓解骨痛降低高钙血症，提高患者的牛活质量。目前放射性核素及双麟酸盐整体治疗的效果较好，并越来越多地为临床医生接受[2],在这方面己进行的临床试验大体上显示这些治疗手段在控制由转移性骨损害所致的疼痛和高钙血症有效，但其疗效持续时间较短，容易再出现新的骨转移病灶[3],其屮一个重耍原因是忽略了同时对原发肿瘤的全身治疗。近几年来本院采用化疗联合放射性核素89SrCL2及哩来磷酸的综合治疗...