呼气峰流速日变异率及哮喘控制测试在哮喘诊治中的作用中南大学湘雅医院林胡诺摘要:目的:探讨呼气峰流速日变异率与哮喘控制测试评分的关系。分别探讨他们在哮喘中的应用价值。方法:选取2013年7月-2013年12月我院门诊就诊哮喘患者64人为研究对象。以一天四次(6:00,12:00,18:00,24:00)方法记录其最大呼气峰流速值(PEF)。计算每日呼气峰流速日变异率及个体平均值,每位患者就诊时常规记录患者哮喘控制测试评分(ACT)及一秒钟呼气率占预计值百分比(FEV1%)。结果:呼气峰流速日变异率显示与FEV1%及ACT评分均无相关关系,但ACT与FEV1%有较好的相关关系(r=0.389,P<0.01),其直线回归关系为FEV1%=55.092±0.995ACT。呼气峰流速日变异率单独诊断哮喘的ROC曲线下面积0.976(截点为0.2,敏感性100%,特异度85.4%,阳性率41%)ACT监测哮喘的ROC曲线下面积0.652,阳性率为34%。呼气峰流速日变异率联合ACT诊断哮喘的ROC曲线下面积0.767(敏感性49%,特异度100%,阳性率54%)。未控制哮喘患者(ACT<20或呼气峰流速日变异率>20%)ACT评分与呼气峰流速日变异率无相关关系,但在哮喘控制较好的患者(ACT≥20及呼气峰流速日变异率≤20%)当中ACT评分与呼气峰流速日变异率有负相关关系(r=-0.602,P≤0.01),其直线回归关系为呼气峰流速日变异率=0.530±0.170ACT。结论:哮喘患者ACT评分可以用于推测患者FEV1%肺功能指标。呼气峰流速日变异率及ACT既能单独监测哮喘,也可以合用提高准确性。在未控制的哮喘患者,即ACT<20或呼气峰流速日变异率>20%者,ACT与呼气峰流速日变异率没有明显的相关关系。但在哮喘控制较好的患者,可以由ACT评分来推测呼气峰流速日变异率值。关键词:呼气峰流速日变异率;哮喘控制测试thevalueofapplicationofpeakexpiratoryflowvariationrateandasthmacontroltestinmonitoringpatientswithbronchialasthma.Abstract:Objective:Inordertoexplorethevalueofapplicationofpeakexpiratoryflowvariationrateandasthmacontroltestinmonitoringpatientswithbronchialasthma.Methods:Sixty-fourasthmaticpatientswerecollectedfromsectionforoutpatientsofthesecondaffiliatedhospitalofwenzhoumedicaluniversitydatingfromjuly.2013toDecember.2013.theirpeakexpiratoryflowreadingsweredeterminedwithfourtimesaday(6:00,12:00,18:00,24:00).Calculatethedailypeakexpiratoryflowvariationrateandtheaverageindividually,atthesametimerecordofasthmacontroltestscores(ACT)andasecondbreathrateofexpectedpercentage(FEV1%).Analysisthevalueofapplicationofpeakexpiratoryflowvariationrateandasthmacontroltestinmonitoringpatientswithbronchialasthma.Results:PeakexpiratoryflowvariationrateshowsnorelationshipwithFEV1%andACTscores,butACThasgoodcorrelationwithFEV1%(r=0.389,P<0.01),thelinearregressionrelationshipisFEV1%=55.092+0.995ACT.theROC-AUCofpeakexpiratoryflowvariationrateinthediagnotionofasthma0.976(cutoffpoint0.2,sensitivity100%andspecificity85.4%,positiverate41%).ThatofACTis0.652,thepositiverateis34%Thatof.呼气峰流速日变异率togetherwithACTis0.394(sensitivity49%,specificity100%,positiverate54%).ACTofPatientswithpoorlycontrolledshowsnocorrelationwith呼气峰流速日变异率,butinpatientswithWellcontrolled,theACTscoresand呼气峰流速日变异率havenegativecorrelation(r=-0.602,P=<0.01),thelinearregressionrelationshipis呼气峰流速日变异率=0.530+0.170ACT.Conclusions:ACTscorecanbeusedtospeculateasthmapatients’FEV1%lungfunctionindex.呼气峰流速日变异率andACTcanbeusedinmonitoringasthmaseparatly,Socantheyusedtogether.Inuncontrolledasthma,namelyACT<20or呼气峰流速日变异率>20%,ACTand呼气峰流速日变异率noobviouscorrelation.Butinpatientswithasthmabettercontrolled,however,doctoerscanseparatePeakexpiratoryflowvariationratebyACTscore.Keywords:Peakexpiratoryflowrate;asthmac...