Aboutpretermuterinechorioamnionitis,fetalmembranesendothelin-1receptorexpressionontheimpactofpretermbirth[Abstract]ObjectiveToinvestigatetheuterinechorioamnionitis,fetalmembranesendothelin-1receptor(ETA)expressingtheimpactofprematureMethodspretermgestationalage28to36weeks,60patientsdividedaccordingtopretermplacentalpathologygroupofpregnantwomeninfectedwith30cases,prematurenon-infectedgroupofpregnantwomen30casesinthecontrolgroupforthesameperiodnormalfull-term(37to41weeksgestation)pregnant30cases;Allcasesweretakenbeforecesareansectionandtheloweruterinesegmentsmoothmusclemembranes,usingimmunohistochemistrystainingandimageanalysisinthedetectionofuterinesmoothmuscleETAafterlabor,fetalmembraneswasdetected.Resultspretermuterinesmoothmusclecellsofpregnantwomeninfectedgroup,ETAcellmembraneswassignificantlyhigherthannormalinpretermandfull-termnon-infectiongroupgroup,thedifferenceswerestatisticallysignificant(P《0.01);---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---pretermpregnantnon-infectedgroupETA,althoughhigherthannormallevelsoffootmonthgroup,butthedifferencewasnotsignificant(P》0.05).ConclusionschorioamnionitiscancausematernaluterinesmoothmusclecellmembranesETAexpressionwassignificantlyincreased.[Keywords:]premature;chorioamnionitis;uterinesmoothmuscle;membranes;endothelin-1receptor[Abstract]ObjectiveToobservetheexpressionofendothalinreceptorAinmyometriumandfetalmembraneofpretermlaborcausedchorioamnionitis.MethodsPatientsofpretermlabor(28~36weeks),60inall,weredividedintopretermlaborinfectiousgroupwithchorioamnionitis(n=30)andpretermlabornoninfectiousgroupwithoutchorioamnionitis(n=30)acorrdingtoplacentalpathologicalresults.Meanwhile,gravidawomen(28~36weeks,n=30)arethecontrolgroup.Allgroupsweredrawnthemyometrium,fetalmembraneduringthecourseofcesarean.Withimmunohistochemitryandimage-analysissystem,theexpressionlevelsofETAweredetectedontissuesofthemyometrium,fetalmembrane---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---regionsinunit.ResultsComparedwiththepretermlabornoninfectiousgrouporthegravidawomen,theexpressionlevelsofETAwashigher(P《0.01)inthepretermlaborinfectiousgroup.ConclusionTheauthorsarguedthatchorioamnionitiswouldplayimportantrolesinsteppinguptheexpressionlevelsofETAonthemyometrium,fetalmembraneregions.[Keywords:]pretermlabor;chorioamnionitis;myometrium;fetalmembrane;endothalinreceptorIPretermbirthiscommonandcomplicatedpregnancycomplications,etiologymore,whichcausedbyavarietyofmicroorganismsandinfectiouschorioamnionitisdevelopmentofprematureclose,isinducedprematurecauseofperinatalmorbidityandmortalityofthemaina[1];iftheycanclarifyitsinducedmechanismwouldclinicalpreventionandtreatmentofinfectiouspretermbirthhaveacertainsignificance.Accordingtoreports,chorioamnionitis,pretermlaboroccurstomakematernalserumintercellularadhesionmolecule-1(sICAM-1)levelsincreased[2],tissueplacentalcytokineinterleukin-6(IL-6)mRNAexpressionwasincreased[3],etc.,butitscauseinfectioninpreterm---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---molecularmechanismsarenotyetfullyclear.endothelin-1(endothalinreceptorA,ET-1)isakindofbiologicaleffectsoftheactivepeptidesintheonsetoflaborhasanegligibleeffect,canstimulateuterinecontractionsandfetalmembranesandothertissuesincreasedsynthesisofprostaglandinssubstance(canstimulateuterinecontractions...