全身麻醉联合硬膜外麻醉在宫颈癌手术中的应用及效果评价邢均摘要：目的分析全身麻醉聯合硬膜外麻醉对宫颈癌手术患者的麻醉效果、应激反应及不良事件。方法选取2015年7月～2017年7月在我院接受腹腔镜术治疗的84例宫颈癌患者临床资料，按照随机数表法分两组，每组42例。对照组行全麻，观察组行全麻+硬膜外麻醉，比较两组麻醉合格率、异氟醚用量、麻醉苏醒时间，麻醉诱导后、建立气腹后、术毕时的应激反应及不良事件发生。结果观察组麻醉合格率为92.85%，高于对照组的71.43%，且观察组异氟醚的用量为（16.21±4.11）ml较对照组的（30.74±5.74）ml少，麻醉苏醒时间为（10.21±2.43）min较对照组的（16.91±1.74）min短，差异均有统计学意义（P<0.05）;观察组术后不良反应率（11.90%）低于对照组（30.95%）（P关键词：宫颈癌;全麻;硬膜外麻醉;应激反应;不良反应：R614;R737.33：ADOI：10.3969/j.issn.1006-1959.2019.01.037：1006-1959（2019）01-0122-04ApplicationandEvaluationofGeneralAnesthesiaCombinedwithEpiduralAnesthesiainCervicalCancerSurgeryXINGJun（DepartmentofAnesthesiology，theFirstHospitalofDanjiangkouCity，Danjiangkou442700，Hubei，China）Abstract：ObjectiveToanalyzetheanestheticeffect，stressresponseandadverseeventsofgeneralanesthesiacombinedwithepiduralanesthesiainpatientswithcervicalcancersurgery.MethodsTheclinicaldataof84patientswithcervicalcancerwhounderwentlaparoscopicsurgeryinourhospitalfromJuly2015toJuly2017wereselectedanddividedintotwogroupsaccordingtotherandomnumbertablemethod，42casesineachgroup.Thecontrolgroupunderwentgeneralanesthesia.Theobservationgroupunderwentgeneralanesthesia+epiduralanesthesia.Theanestheticrate，isofluranedosage，anesthesiarecoverytime，post-anesthesiainduction，post-pneumoperitoneum，andpostoperativestressresponsewerecompared.Adverseeventsoccurred.ResultsTheanesthesiarateoftheobservationgroupwas92.85%，whichwashigherthanthatofthecontrolgroup（71.43%）.Theamountofisofluraneintheobservationgroupwas（16.21±4.11）mllessthanthatofthecontrolgroup（30.74±5.74）ml，andtheanesthesiarecoverytimewas（10.21±2.43）minwasshorterthanthecontrolgroup（16.91±1.74）min，thedifferencewasstatisticallysignificant（P<0.05）.TheHRoftheobservationgroupafterinductionofanesthesia，afterestablishmentofpneumoperitoneumandatthetimeofsurgerywere（80.64±7.53）.）times/min，（77.47±9.78）times/min，（78.52±7.92）times/minlowerthanthecontrolgroup（91.39±8.92）times/min，（94.69±7.80）times/min，（93.68±8.47）times/min;theSBPoftheobservationgroupwere（138.26±11.21）mmHg，（143.23±15.84）mmHg，（145.74±14.09）mmHg，whichwaslowerthanthatofthecontrolgroup（146.79±10.41）mmHg，（152.76±14.18）mmHg，（156.18±10.21）mmHg，DBPwere（76.03±5.26）mmHg，（77.92±8.71）mmHg，（79.81±9.23）mmHg，whichwaslowerthanthatofthecontrolgroup（82.56±6.37）mmHg，（93.68±8.34）mmHg，（92.31±9.57）mmHg（P<0.05）;theadversereactionrate（11.90%）intheobservationgroupwaslowerthanthatinthecontrolgroup（30.95%）（P<0.05）.ConclusionGeneralanesthesiacombinedwithepiduralanesthesiaiseffectiveforcervicalcancersurgery，whichisbeneficialtostabilizethepatient'scentralrate，bloodpressure，surgicalstress，andlesspostoperativeadversereactions.Keywords：Cervicalcancer;Generalanesthesia;Epiduralanesthesia;Stressresponse;Adversereactions宫颈癌（cervicalcancer）是一种好发于女性生殖道的恶性肿瘤，在全球女性恶性肿瘤疾病中居第3位，常发生于宫颈阴道、宫颈管内膜柱状上皮细胞与移行带鳞状上皮细胞二者交汇处，以手术治疗为主[1]。近年来，临床开始重视微创外科手术的治疗...