单唾液酸治疗新生儿缺血缺氧性脑病黄娜（第四军医大学丙京医院儿科陕丙丙安710000）【摘要】目的：探讨单唾液酸治疗新生儿缺血缺氧性脑病的临床效果。方法:抽取我院2010年1月〜2012年1月收治的新牛JL缺血缺氧性脑病共96例，结合患儿入院时间先后将其分为观察组（48例）和对照组（48例），对照组患儿均给予酸中毒纠正、血压血糖控制、惊厥控制、液体摄入量限制、颅内压降低、脑干症状消除以及二胆碱应用等常规治疗，观察组患儿则在上述常规治疗基础上应用单唾液酸四己糖神经节苷脂治疗，对比两组患儿治疗效果差异，统计两组患儿治疗前后祌经行为测定标准结果（NBNA）的差异，测定两组患儿症状恢复时间，统计两组患儿治疗过程中不良反应发生率。结果：观察组患儿治疗有效率91.7%,对照组患儿治疗有效率72.9%,差异显著（P<0.05）。观察组患儿在意识障碍、惊厥、原始反射、肌张力、颅内压等临床症状恢复时间上均小于对照组,差异显著（P<0.05）。观察组患儿治疗后NBNA评分明显高于对照组，差异显著（P<0.05）。两组患儿治疗过程中均未见明显不良反应。结论：单唾液酸四己糖祌经节苷脂治疗新生儿缺血缺氧性脑病有着极好的临床效果，能够促进患儿临床症状快速恢复，改善患儿行为神经功能，同时具有安全性高的特点，值得临床推广。【关键词】单唾液酸四己糖祌经节苷脂；新生儿缺血缺氧性脑病；症状恢复时间；神经行为测定【中图分类号】R722【文献标识码】A【文章编号】2095-1752（2016）15-0093-03SinglesialicacidtreatmentofneonatalhypoxicischemiaencephalopathyHuangNaXikingfourthmilitarymedicaluniversityhospitalofpediatrics,710000,China【Abstract】ObjectiveTostudytheclinicaleffectforthetreatmentofneonatalhypoxicischemiaencephalopathy.MethodsExtractionfromJanuary2010〜January201296caseswithneonatalhypoxicischemiaencephalopathyweretreated,combinedwiththechildreninhospitaltimehasdividedintoobservationgroup(48cases)andcontrolgroup(48cases)andcontrolgroupofchildrenweregivenacidosiscorrection,bloodpressure,bloodsugarcontrol,convulsioncontrol,fluidintakerestriction,intracranialpressuretoreduce,thebrainstemsymptomstoeliminateconventionaltreatments,suchasbagstwocholineapplicationwhiletheobservationgroupwiththeconventionaltreatmentbasedontheapplicationofsinglefourhexosegangliosidesialicacidtreatment,comparethetreatmenteffectofdifferencesintwogroupsofchildren,thestatisticaldeterminationoftwogroupsbeforeandaftertreatmentinchildrenwithneuralbehavior(NBNA)theresultsofthestandarddifference,thedeterminationoftwogroupsofchildrenwithsymptomsofrecoverytime,incidenceofadversereactionsinstatisticaltreatmentprocessintwogroupsofchildren.ResultsThetreatmenteffectiveratewas91.7%inobservationgroupchildren,childrenwiththecontrolgrouptreatmenteffectiveness72.9%,significantdifference(P<0.05).Observationgroupofchildreninthedisturbanceofconsciousness,convulsion,clinicalsymptomsuchasprimitivereflex,muscletension,intracranialpressurerecoverytimeislessthanthecontrolgroup,significantdifference(P<0.05).NBNAscoreaftertreatmentinchildrenwithobservationgroupwasobviouslyhigherthanthatofcontrolgroup,significantdifference(P<0.05).Treatmentprocessintwogroupsofchildrenhavenoobviousadversereactions.ConclusionSinglesialicacidfourhexosegangliosidetreatmentofneonatalhypoxicischemiaencephalopathyhasverygoodclinicaleffect,canpromotechildrenwithclinicalsymptomsquicklyrecover,childrenimprovebehaviornervefunction,alsohasthecharacteristicsofhighsafety,worthclinicalpromotion.【Keywords]Singlefourhexosegangliosidesialicacid;Neonatalhypoxicischemiaencephalopathy;Symptomsofrecoverytime;Determinationofneurobehavioral缺血缺氧性脑病简称HIE,是-•种...