•临床研究•丁苯猷注射液治疗急性脑梗死疗效的初步探讨唐鹏，刘明，刘鹏，种莉，李晓青，陈丽，郭民侠，李锐*(陕西省人民医院神经内三科，西安710068)【摘要】目的评价丁苯猷注射液对急性脑梗死的疗效及药物不良反应。方法选择陕西省人民医院70例急性脑梗死住院患者随机分为治疗组(/7=35)和对照组(77=35),对照组仅予常规治疗，治疗组在常规治疗的基础上给予丁苯猷注射液治疗。于治疗前及治疗后14d进行神经功能缺损程度评定(NIHSS评分)和日常生活自理能力评定(Barthel指数和mRS评分)并记录不良反应。90d随访时再次评定Barthel指数和mRS评分。结果与治疗前相比，治疗后14d两组NIHSS评分均下降，治疗组优于对照组[治疗组(13.60±4.26)V5(9.31±3.79),对照组(13.57±4.20)V5(11.23±4.06),0.045]。与治疗前相比，治疗后14d两组Barthel指数差异无统计学意义；随访90d时两组Barthel指数均明显升高，且治疗组优于对照组[治疗组(54.57±24.17)vs(77.86±21.46),对照组(54.14±23.8I)V5(67.0±23.30),0.047]。与治疗前相比，治疗后14d两组mRS评分变化不明显；治疗后90d,治疗组mRS评分较治疗前明显减低，且治疗组优于对照组[治疗组(3.40±0.81)V5(2.80±0.96),对照组(3.49±0.82)V5(3.29±0.93),0.035]。两组不良反应发生率相似。结论丁苯瞰注射液可改善急性脑梗死所致的神经功能缺损，改善90d远期预后，安全性良好。【关键词】丁苯酰；脑梗塞；治疗效果【】R743.33【文献标识码】A[DOl]?Dl-3-n-butyphthalideforthetreatmentofacutecerebralinfarctionTANGPeng,LIUYue,LIUPeng,CHONGLi,LIXiao-Qing,CHENLi,GUOMin-Xia,LIRui*(TheThirdDepartmentofNeurology,ShaanxiProvincialPeople'sHospital,Xi'an71006China)[Abstract]ObjectiveToevaluatethetherapeuticeffectsandadversedrugreactionsofDl・3・n・butyphthalidc(NBP)injectionforacutecerebralinfarction.MethodsSeventycasesofacutecerebralinfarctionpatientsfromShaanxiProvincialPeople'sHospitalwererandomlydividedintostandardtreatmentplusDl・3・n・butyphthalidcinjection(//=35)andstandardtreatment(Control,n=35).Thedegreeofneurologicaldeficit(NIHSSscore)anddailylivingskillsassessment(BarthelIndexandthemRSscore)wereassessedandadversereactionswererecordedbeforeand14daysafterthetreatment.BaMhelIndexandthemRSscorewerefollowedup90daysafterthetreatment.ResultsAfter14days,NIHSSscoresofbothNBPandcontrolgroupsweredecreasedascomparedwithpretreatment.ThedecreaseofNIHSSinNBPgroupwasmoresignificantthancontrolgroup[NBPgroup(13.6014.26)vs(9.31±3.79),controlgroup(13.5714.20)vs(11.2314.06),P=0.045)].NoobviouschangeinBarthelindexintwogroupswereidentifiedat14daysaftertreatment.Barthelindexat90daysoffollow-upweresignificantlyhigherinNBPgroupthancontrolgroup[NBPgroup(54.57±24.17)vs(77.86121.46),controlgroup(54.14±23.81)vs(67.0±23.30),P=0.047].After14days,mRSscoresofbothgroupsdidnotchangesignificantly;after90days,thedecreaseofmRSscoresinNBPgroupwasmoresignificantthancontrolgroup[NBPgroup(3.40±0.81)vs(2.8010.96),controlgroup(3.4910.82)vs(3.2910.93),P=0.035]•Incidenceofadversereactionswassimilarbetweentwogroups.ConclusionNBPinjectioncanimproveneurologicaldeficitand90-dayoutcomeofacutecerebralinfarctionwithgoodtolerability.[Keywords]Dl-3-n-butyphthalide;braininfarction;treatmentoutcomeThisworkwassupportedbyShaanxiInnovativeResearchTeamforKeyScienceandTechnology(No.2012KCT-17).Correspondenceauthor:LIRui,E-mail:stroke@l26急性脑梗死是最常见的脑血管疾病之一，其(dl・3・n・butyphthalide,NBP)是我国脑血管领域发病率、致残率及病死率均较高。丁苯猷拥有自主知识产权的一类化学新药，已广泛用于---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---临床治疗急性脑梗死，药理研究表明该...