丹红注射液治疗老年人椎基底动脉供血不足临床疗效观察［摘要］目的观察丹红注射液治疗老年人椎一基底动脉供血不足（VBI）患者的临床疗效。方法将64例椎基底动脉供血不足患者随机分为两组，治疗组（32例）用生理盐水250mL加入丹红注射液20mL,静脉滴注，1次/d；对照组（32例）用生理盐水250mL加入丹参注射液20mL,静脉滴注，1次/d,两组均治疗14d为1个疗程。治疗后观察临床疗效经颅彩色多普勒超声（TCD）血流速及血液流变学变化。结果治疗组有效率为90.63%,对照组为71.88%,两组疗效比较差异有高度统计学意义（P0.05）,治疗组与对照组治疗后比较差异有统计学意义（P〈0.05）。结论丹红注射液临床疗效显著，能明显增加稚一基底动脉血流量，改善微循环，降低血黏度。［关键词］丹红注射液；椎基底动脉；彩色多普勒超声血液流变学；临床疗效［中图分类号］R441.2［文献标识码］A［文章编号］1673-7210（2012）07（a）-0109-03ClinicalobservationonthetherapeuticeffectofDanhongInjectioninthetreatmentofseniorpatientswithvertebrobasilarinsufficiencyDENGYuhangYANGYichaoZHANGLiwenDepartmentofEmergency,ShenzhenFutianTraditionalChineseMedicalHospitalAffiliatedtoHu'nanUniversityofChineseMedicaly,GuangdongProvince,Shenzhen518034,China[Abstract]ObjectiveToobservetheclinicaltherapeuticeffectofDanhongInjectioninthetreatmentofseniorpatientswithvertebrobasilarinsufficiency(VBI)・Methods64patientswererandomlydividedintotreatmentgroup(n二32)andcontrolgroup(n二32).Thetreatmentgroupwastreatedbynormalsaline(250mL)plusDanhongInjection(20mL)withMainlineonetimeeachday.Thecontrolgroupwastreatedbynormalsaline(250mL)plusDanshenInjection(20mL)withMainlineonetimeeachday.ThePeriodoftreatmentislasting14days・After14days'therapy,theclinicaltherapeuticeffectandchangesintheparametersofTCDandhemorheologywereobserved.ResultsThetotaleffectiverateinthetreatmentgroupwas90.63%but71.88%incontrolgroup(P<0.01).ThroughTCD,measuringbloodflowvelocity,itwassignificantlyincreasedaftertreatmentthanbeforetreatmentintwogroups(P<0.01),thetreatmentgroupwassignificantincreasedthanthatofcontrolgroup(P<0・05).Aftertherapy,theparametersofhemorheologyaftertherapycomparedwithbeforetherapyintreatmentgroup,therewassignificantdifference(P<0.01),andtherewasnosignificemtdifferenceincontrolgroup(P<0.05).ConclusionDanhongInjectionshowsasignificantclinicaltherapeuticeffectinthetreatmentofpatientswithVBI.ItisabletoincreasebloodflowvaulewithVBI.ItisabletoimprovetheMicrocirculationandtodecreasetheBloodviscosity.[Keywords]DanhongInjection；VBI；Colordopplerultrasonography；Hemrrheology；Clinicaltherapeuticeffect
