多发性骨髓瘤骨病发病机制及细胞因子靶向治疗?1553?不应答,Pokemon在多种人类肿瘤中过表达。由于Pokemon在肿瘤细胞转化过程屮发挥关键作用并与肿瘤发生密切相关，因此，有望成为肿瘤治疗的新鞘点。参考文献：[1]PesslerF,PendergrastPS,HernandezN.Purificationandcharacteriza2tionofFBI21,acellularfactorthatbindstothehumanimmunodeficien2cyvirustypelinducerofshorttranscripts[J].MolCellBiol,1997,17(7):378623798.[2]MorrisonDJ,PendergrastPS,StavropoulosBetaLFBI,afactorthatbindstotheHIV21inducerofshorttranscripts(IST),isapo政法omainprotein[J].NucleicAcidRes,1999,5(27):125121262.[3]DaviesJM,HaweN,KabarowskiJ,etal.NovelBTBnPO政法omainzinc2fingerprotein,LRF,isapotentialtargetoftheLAZ23nBCL26oncogene[J].Oncogene,1999,18(2):3652375.[4]LeeDK,KangJE,ParkHJ,etal.FBI21enhancestranscriptionoftheKKnuclearfactor2B(NF2B)2responsiveE2selectingenebynuclearlocal2Kizationofthep65subunitofNF2B[J].JBiolChem,2005,280(30):27783227791.[5]DhordainP,AlbagliO,AnsieauS,etal.TheBTBnPO政法omaintargetstheLAZ3nBCL6oncoproteintonucleardotsandmediateshomoninvivo[J].Oncogene,1995,11(12):26892[6]PendergrastPS,WangCN,BI2stimulate2lTatactivityandisatheTat2Pol,2002,13(3):915[7]MaedaT,HRSerghoubT,etal.RoleoftheprotooncogenePokemonincellulartransformationandARFrepression[J].Nature,2005z433(7023):2782285.[8]LeeDK,SuhD,EdenbergHJ,etal.PO政法omaintranscriptionfactor,FBI21,repressestranscriptionofADH511FDHbyinteractingwiththezincfingerandinterferingwithDNAbindingactivityofSpl[J].JBiolChem/2002/277(30):26761226768.[9]LiuCJ'PrazakL'FajardoM'YuS'etal丄eukemianIymphoma2relatedfactor,aPO政法omain2containingtranscriptionalrepressorJnteractswithhistonedeacetylase21andinhibitscartilageoligomericmatrixproteingeneexpressionandchondrogenesis[J]」BiolChem,2004,279(45):47081247091.[10]lssackPS,FangC,LeslieMP,etal.Chondrocyte2specificenhancerre2gionsintheCOMPgene[J].JOrthopRes/2000/18(3):3452350.[ll]IssackPS'LiuCJ'PrazakL'etal.Asilencerelementinthecartilageoligomericmatrixproteingeneregulateschondrocyte2specificexpression[J].JOrthopRes,2004,22(4):7512758.[12]BardwellVJ,TreismanR.ThePOZprotein2protein].Genes,8)21677.[13]OPC.PO政法omain:anewmandactin2binding].G():119321198[14AB,etal.N2CoRmediatesDNAmeth2repressionthroughamethylCpGbindingprotein].MolCell,2003,12(3):7232734.[15]PintardL,WillemsA,PeterM.Cullin2basedubiquitinligases:Cul32BTBcomplexesjointhefamily[J].EMBOJ,2004,23(8):168121687.收稿日期:2006212227修回日期:2007208206肖萍萍(線述)，陈©敏,叶德富(市校)(福建医科大学附属第一医院血液内科，福州350005):R733.3文献标识码:A:100622084(2007)2021553204轻，呈暂时性、游走性或间歇性，因而可能被误诊为风湿性疾病如肋软骨炎、腰椎骨质增生、腰椎间盘突出及脊椎结核等。随着病情进展骨痛可变为持续性，疼痛剧烈，常因运动、负重或咳嗽而加重。骨痛部位以腰骶部最多PathogenesisandCytokineTargetedTherapyofMyelomaBoneDiseaseXIAOPing2ping,CHENJun2见,其次为胸肋部和四肢长骨。疼痛min,YEDe2fu.(DepartmentofHematology,theFirstAffiliatedHospitalofFu激anMedicalUniversity,Fuzhou350005,China)突然加重提示有病理性骨折，发生部Abstract:Multiplemyeloma(MM)isahematologicalmalignancy.Myelomabonedisease(MBD)isa位多见于肋骨、下位胸椎及上位腰椎，commonandseriouscomplicationinpatientswithMM,whichwillresultinseverebonepain,pathologicfrac2其他部位还有锁骨及胸骨。骨折可发tures,hypercalcemiaandnervecompressionsyndromesaswellasaffectthesurvivalquantityandprognosisofpatientswithMMgreatly.ltspathogenesyisnot...