D01：10.13210/j.cnki.jhmu,20170627.004网络出版地址:http://kns.cnki.nct/kcms/detail/46.1049.R.20170627.1708.008.htmlNT-proBNP.心肌酶及炎性细胞因子检测对急性冠状动脉综合征患者的临床意义赵红梅】，崔海涛2(1.张家口市第五医院检验科,2.张家口市第一医院普通外科，河北张家口075000)［:摘要］日的：探讨氨基末端脑钠肽前体(NT-proBNP)、心肌酶学及血清炎性细胞因子在急性冠状动脉综合征(ACS)患者中的临床意义。方还：选取我院行冠状动脉造影响(CAG)确诊的ACS患者120例为研究对象，根据病变程度分为不穗定型心绞痛(UAP组)28例，急性非ST段抬高心肌梗死(NSTEMI组)41例，急性ST段抬高心肌梗死(STEMI组)51例，另选取同崩行CAG阴性患者40例为对照组，采用标准Judkins法行冠状动脉造影(CAG)检查，多体位投照确定冠脉病变程度，于入院时采集外周挣脉血，分离血滑，采用荧光免疫吸附法测定NT-proBNP、肌酸激酶同工酶(CK-MB)水平；化学发光法测定心肌肌钙蛋白I(cTnl)水平；免疫比浊法测定超敏C反应蛋白(hs-CRP)水平；酶联免疫法测定白细胞介素-18(IL-18)、肿瘤坏死因子-a(TNF-a)、基质金属蛋白酶-9(MMP-9)水平。锥杲：对照组、UAP组、NSTEMI组、STEMI组血清NT-proBNP、CK-MB、cTnI、hs-CRP、IL-18、TNF-a和MMP-9水平呈依次增高趋势，各组间比较差异均有统计学意义(P<0.01)o馆论：血清NT-proBNP、CK-MB、cTnI、hs-CRP、IL-18、TNF-a、MMP-9联合检测对ACS的诊断、严重程度评估、危险分层、治疗方案制定等有重要意义。［关键词］NT-proBNP；心肌酶学；血清炎性纺胞因子；急性冠状动脉综合征［中图分类号］R541.4［文献标识码］A［文章编号］1007-1237(2017)12-1623-04ClinicalsignificanceofNT-proBNP,myocardialenzymes,andinflammatorycytokinesindi-agnosisofacutecoronarysyndromeZHAOHong-mei1,CUIHai-tao2(1.DepartmentofClinicalLaboratory,theFifthHospitalofZhangjiakouCity,075000j2.DepartmentofGeneralSurgtry,theFirstHospitalofZhangjiakouCity,075000)［foundationProject、农studyzuusupportedbytheScientificandTechnologicalProgressProjectofHebeiPnnjinctxiiththenumberof20152297.\_Author"}-ZHAOHong-mei(1981-).Female.undergraduate,supervisorlaboratorian,Tel:13833332256.E-maiZ:wangyxt!977@163.com.Received:2017-06-07Revised:2017-06-13JHMC,2O17；23(12)：1623-1626Viewfromspecialist：Itiscreative,andofcertainscientificandeducationalvalue.［ABSTRACT］Objective:ToexploretheclinicalsignificanceofNT-proBNP,myocardialenzymes,andinflammatorycyto-kinesindiagnosisofacutecoronarysyndrome(ACS).Methods：Atotalof120patientswithACSconfirmedbyCAGwhowereadmittedinourhospitalfromDecember,2014toDecember,2016wereincludedinthestudyanddividedintoUAPgroup(n=28),NSTEMIgroup3=41),andSTEMIgroup(n=51)accordingtodifferentlesiondegrees.Moreover,40caseswithneg-ativeCAGresultswereservedasthecontrolgroup.ThestandardJudkinsmethodwasusedforCAGexamination.Multi-posi-tionprojectionwasperformedtoconfirmthecoronarylesiondegrees.Theperipheralvenousbloodwascollectedonadmission,andtheserumwasseparated.ThefluorescenceimmunoassaywasusedtodetectNT-proBNPandCK-MBlevels.Thechemilu-［基金项目］河北省科技进步项目(20152297)［作者简介］赵红梅(1981-),女，本科，学士，主管检验师.电话：13833332256,E-mail,wangyxtl977@163.com.「收稿日期】2017-06-07「修回日期12017-06-13网路出版时间,2017-6-2717,08miniscencewasusedtodetectcTnllevel.Theimmunoturbidimetrywasusedtodetecths-CRPlevel.ELISAwasusedtodetectIL-18.TNF-a,andMMP-9levels.Results：TheserumNT-proBNP.CK-MB,cTnl.hs-CRP.IL-18,TNF-a.andMMP-9levelsweregraudallyincreasedinthecontrolgroup*UAPgroup,NSTEMIgroup,andSTEMIgroup*andthecomparisona-mongeachgroupwasstatisticallysignificant(PV0.01).Conclusions：ThecombineddetectionofserumN...