支原体肺炎患儿应用阿奇霉素序贯疗法的有效性评定（德阳市人民医院儿科四川德阳618000）【摘要】目的：探讨支原体肺炎患儿应用阿奇霉素序贯疗法的有效性。方法：根据随机数字表法进行2016年6月—2018年4月90例支原体肺炎患儿分成不同组。对照组给予常规化痰解痉、吸氧等疗法治疗，观察组则给予常规化痰解痉、吸氧等疗法联合阿奇霉素序贯疗法治疗。比较两组支原体肺炎治疗效果；啰音消失时间、咳嗽消失时间、发热消失时间、喘息消失时间；治疗前后患儿TNF-α、CRP、IL-6；治疗前后患儿TNF-α、CRP、IL-6；治疗前后FEV1、VC水平；用药副作用发生率。结果：观察组支原体肺炎治疗效果高于对照组，P＜0.05；观察组啰音消失时间、咳嗽消失时间、发热消失时间、喘息消失时间优于对照组，P＜0.05；治疗前两组TNF-α、CRP、IL-6相近，P＞0.05；治疗后观察组TNF-α、CRP、IL-6优于对照组，P＜0.05。治疗前两组FEV1、VC相近，＞0.05；治疗后观察组FEV1、VC优于对照组，P＜0.05。观察组用药副作用发生率和对照组无明显差异，P＞0.05。结论：常规化痰解痉、吸氧等疗法联合阿奇霉素序贯疗法治疗支原体肺炎的应用效果确切，可有效降低机体炎症水平，改善肺功能，无严重e副作用，安全有效，值得推广应用。【关键词】支原体肺炎患儿；阿奇霉素序贯疗法；有效性【】R720.5【文献标识码】A【】2095-1752（2018）21-0204-03EffectivenessevaluationofazithromycinsequentialtherapyinchildrenwithmycoplasmapneumoniaLiuLin,GaoWenbo,LiuQianfang.People’sHospitalofDeyangCity,Deyang,Sichuan,618000,China【Abstract】ObjectiveToinvestigatetheeffectivenessofazithromycinsequentialtherapyinchildrenwithmycoplasmapneumonia.Methods90caseswithmycoplasmapneumoniafromJune2016toApril2018wererandomlypidedintogroups,thecontrolgroupwasgivenroutinetreatmentofphlegmdispersing,spasmolysis,oxygenuptake,theobservationgroupwasgivenazithromycinsequentialtherapyonthisbasis.Thetreatmenteffect,extinctiontimeofrale,cough,fever,TNF-α,CRP,IL-6andFEV1,VClevelsbeforeandaftertreatment,adversesideeffectratebetweenthetwogroupswerecompared.ResultsTreatmenteffectoftheobservationgroupwashigherthanthatofthecontrolgroup,P＜0.05;theextinctiontimeofrale,cough,feverintheobservationgroupwasbetterthanthatinthecontrolgroup,P＜0.05;beforetreatment,TNF-α,CRP,IL-6ofthetwogroupsweresimilar,P＞0.05;aftertreatment,TNF-α,CRP,IL-6oftheobservationgroupwerebetterthanthoseofthecontrolgroup,P＜0.05.Beforetreatment,FEV1,VCofthetwogroupsweresimilar,P＞0.05;aftertreatment,FEV1,VCoftheobservationgroupwerebetterthanthoseofthecontrolgroup,P＜0.05.Therewasnostatisticsignificanceintheadversesideeffectratebetweenthetwogroups,P＞0.05.ConclusionTheapplicationofroutinetreatmentofphlegmdispersing,spasmolysis,oxygenuptakecombinedwithazithromycinsequentialtherapyinchildrenwithmycoplasmapneumoniahaveaccurateeffect,itcaneffectivelyreducethesystemicinflammatorylevel,improvethelungfunction,noseveresideeffect,itissafeandworhtyofpromotion.【Keywords】Childrenwithmycoplasmapneumonia;Azithromycinsequentialtherapy;Effectiveness儿童肺炎支原体肺炎是常见的临床疾病，发病率逐年上升，是儿科常见的疾病之一。研究表明，儿童感染肺炎支原体后，可引起支气管、肺泡损害并诱发免疫反应，引起肾脏、肝脏、神经等系统和器官病变，对小儿健康产生严重危害。研究显示，在2至12岁的儿童中经常发生支原体肺炎。这种疾病临床症状有发热、咳嗽等，且支原体肺炎传染性高，病情严重，疾病持续时间长，在疾病早期阶段无特征性临床表现，往往容易出现漏诊和误诊。目前关于口服阿奇霉素治疗儿童肺炎支原体肺炎研究不断增多，阿奇霉素在用药效果和安全性方面已得到肯定，但单一用药或静脉滴注治疗均有其缺陷，很难保证疗效。本研究根据随机数字表法进行2...