壮药白花九里明对高血压大鼠模型的心血管功能保护作用的实验研究黎飞彤方高根王彩冰孙悦黄章南黎智丹王秋君【摘要】目的探討白花九里明对高血压大鼠模型的心血管功能保护作用。方法将SD大鼠48只随机均分为正常对照组和高血压模型组、替米沙坦组及白花九里明低、中、高浓度组，每组8只大鼠，每天灌胃一次，灌胃量按大鼠体重10mL/kg计算，连续7天;同时，正常对照组给予0.9%氯化钠注射液，其余各组给予5mg/mL地塞米松注射液，每天皮下注射一次，注射量按大鼠体重3mL/kg计算，连续7天。各组大鼠于末次用药后30min经左侧颈总动脉插管和右侧颈外静脉插管测定收缩压（SBP）、舒张压（DBP）、心率（HR）、中心静脉压（CVP）。结果高血压模型组的SBP、DBP明显高于其余各组（P<0.05或0.01），替米沙坦组的SBP、DBP明显低于其余各组（P0.05）。各组的HR、CVP在组间两两比较均无统计学意义（P>0.05）。结论白花九里明能抵消地塞米松诱导高血压模型的血管收缩和高血压现象，使血压恢复正常，也能消除地塞米松对心脏生物电干扰和心泵功能降低的不良趋向，达到保护心血管功能的作用。【关键词】白花九里明;高血压模型;血压;心率;中心静脉压;大鼠：R29;R932;R544.1;R285.5文献标志码：ADOI：10.3969/j.issn.1003-1383.2021.04.003ExperimentalstudyonprotectiveeffectofZhuangmedicineblumeamegacephalaoncardiovascularfunctioninratmodelofhypertension[HJ2][HJ]LIFeitong1，FANGGaogen1，WANGCaibing2，SUNYue3，HUANGZhangnan3，LIZhidan3，WANGQiujun3（1.UndergraduateofClinicalMedicine，Grade2016，2.DepartmentofPhysiology，3.UndergraduateofClinicalMedicine，Grade2017，YoujiangMedicalUniversityforNationalities，Baise533000，Guangxi，China）[HJ2][HJ]【Abstract】ObjectiveToexploretheprotectiveeffectofblumeamegacephalaoncardiovascularfunctioninhypertensiveratmodel.Methods48SDratswererandomlydividedintonormalcontrolgroupandhypertensionmodelgroup，telmisartangroup，blumeamegacephalalow，mediumandhighconcentrationgroups，with8casesineachgroup.Theratswereintragastricallyadministeredonceadayfor7consecutivedaysaccordingtobodyweight（10mL/kg）.Atthesametime，thenormalcontrolgroupweregiven0.9%sodiumchlorideinjection，andtheothergroupsweregiven5mg/mLdexamethasoneinjection，subcutaneousinjectionwasperformedonceadayfor7consecutivedays，theinjectionvolumewascalculatedaccordingtotheweightofrats（3mL/kg）.30minutesafterthelastadministration，systolicbloodpressure（SBP），diastolicbloodpressure（DBP），heartrate（HR）andcentralvenouspressure（CVP）ofeachgroupweremeasuredbyleftcommoncarotidarteryintubationandrightvenajugularisexternaintubation.ResultsSBPandDBPinthehypertensionmodelgroupweresignificantlyhigherthanthoseinothergroups（P<0.05or0.01），SBPandDBPinthetelmisartangroupweresignificantlylowerthanthoseinothergroups（P<0.05or0.01）.TherewasnostatisticallysignificantdifferenceinSBPandDBPbetweentheblumeamegacephalalow，mediumandhighconcentrationgroupsandthenormalcontrolgroup（P>0.05）.DifferenceofHRandCVPinpairwisecomparisonbetweengroupswasnotstatisticallysignificant（P>0.05）.ConclusionBlumeamegacephalacannotonlycounteractthevasoconstrictionandhypertensionphenomenonofdexamethasoneinducedhypertensionmodel，makethebloodpressurereturntonormal，butalsoeliminatetheadversetrendofdexamethasoneoncardiacbioelectricityinterferenceandcardiacpumpfunctionreduction，soastoprotectcardiovascularfunction.【Keywords】blumeamegacephala;hypertensivemodel;bloodpressure;HR;CVP;rat白花九里明（blumeamegacephala〔Randeria〕ChangetTseng）属菊科植物，在壮族民间常用于治疗跌打肿痛、风湿骨痛、产后出血、月经不调等[1～2]。近年有文献报道[3]，...