[摘要]目的:探讨口服普蔡洛尔治疗婴幼儿血管瘤的临床疗效、安全性及方法。方法:共收治56例体表血管瘤患儿,完善检查后口服普蔡洛尔治疗,初始剂量为0.5mg/kg/d,分2次餐后服用,若患儿无不良反应,则每日增加0.2mg/kg至总量1.5mg/kg/d,维持治疗4个月后每日减少0.2mg/kg至停药,治疗结束半年后参照Achauer标准进行疗效评定。结果:其中1例服药不到1个月因岀现疲劳、乏力,家属放弃治疗,2例服药3个月后瘤体基本消退而停药,其余53例均维持服药4个月,治疗结束时,大部分血管瘤明显缩小,颜色变淡,甚至消退,停药6个月后评定疗效:I级2例(含复发1例),II级6例(含复发5例),III级17例,IV级31例,停药后复发6例。结论:口服普蔡洛尔是治疗婴幼儿血管瘤有效方法之一,其疗效及安全性可能与剂量及用药方式有关。[关键词]血管瘤;血管性疾病;普荼洛尔[1R732.2[文献标识码]A[文章编号]1008-6455(2014)17-1449-05Clinicalstudyonoralpropranololtherapyfor---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---infantilehemangiomaslocatedinsuperficialbodyFUShi-zhang,HUANGHe-ping,HUANGLin-ling(DepartmentofCosmeticandPlastic,激angxiWomenandChildrenHealthCareHospital,Nanchang330006,激angxi,China)Abstract:ObjectiveToexploretheefficacy,safetyandappropriatemethodoforalpropranololtreatmentforinfantilehemangiomaslocatedinsuperficialbody・Methods56infantswithhemangiomasinsuperficialbodyweretreatedfromJanuary2010toJanuary2013,including17malesand39females,withagerangedfrom3to24months.Propranololwasadministeredorallytwiceadayaftermealtoallthecasesafterexamination,whichwasbegunwith0.5mg/kg/d,andwasadded0.2mg/kgeverydaytillitaddedupto1.5mg/kg/donlyifcomplicationswerenotoccurredinthecases,andwasdecreasedby0.2mg/kgeverydaytowithdrawlwhenwastakenatthisdosefor4months.ThetherapyeffectafterstoppingtreatmentforsixmonthswasevaluatedusingAchauersystem・Results53casestookpropranololfor4months,exceptthat1cas---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---egaveuptherapybecauseofobviousfatigueduringthefirstmonthoftreatment,and2casesendedtreatmentastheyhadgottencuredalmostlyaftertakingpropranololfor3months.Mosthemangiomasdecreaseddistinctlyinsizeandcolor,andevensomedisappearedcompletelywhentreatmentfelldue.2caseswerescaleI(including1recurrenee),6caseswerescaleII(including5recurrence),17caseswerescalellland31caseswerescalelVaftersixmonthsofpropranololwithdrawal.ConclusionOralpropranololisoneofeffectivemethodsforinfantilehemangiomas,boththeefficacyandsafetyareprobablyrelativetoitsdoseandusage・Keywords:hemangioma;vasculardisease;propranolol自从2008年法国医生Leaute-Labreze意外发现口服普蔡洛尔可促使婴幼儿血管瘤消退后,近年来,国内外有许多关于口服普蔡洛尔治疗婴幼儿血管瘤的文献报道及相关研究,2010年1月〜2013年1月,笔者科室尝试口服普荼洛尔治疗婴幼儿体表血管瘤患儿56例,取得了满意疗效,现将结果报道如下。1资料和方法1.1一般资料:本组56例,均为未经治疗的体表血管瘤---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---患儿,排除哮喘病史。其中男17例,女39例;年龄3〜24个月,中位年龄5个月;颜面部31例,头部2例,躯干7例,四肢11例,会阴部2例,全身多发3例。入院检查可见瘤体呈鲜红或暗红色草莓状突出皮面,界限清楚,压之退色,无触痛。瘤体范围大小0.8cmX0.6cm〜4.0cmX4.5cm。1.2治疗方法:治疗前先向患者家属说明该治疗的可行性、安全性及可能岀现的并发症,征得患儿家属同意后,对患者进行常规检查,排除哮喘及心电图异常等情况后,根据患者体重口服普荼洛尔治疗,初始剂量为每日0.5mg/kg,分2次餐后服用,服药后观察患者生命体征及有无不适或不良...