基于数据挖掘探讨疫病学说对儿童新型冠状病毒性肺炎的用药启发黄小靖刘卓超宋银枝林丰夏许禄华摘要本研究通过中医传承辅助平台（V2.5）探讨疫病学说对儿童新型冠状病毒性肺炎的用药启发。收集《温病大成（第一部）》中关于治疗小儿时疫的处方，筛选出适用于现在治疗小儿时疫的完整处方58个，将处方录入中医传承辅助平台（V2.5），运用其集成规则分析、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类分析等功能总结明清医家治疗小儿时疫的理论依据和用药规律。根据统计分析结果得出明清医家治疗小儿时疫的药物频次和药物间关联规则，最终获得核心药物组合16个，提取新方8个。结果表明，儿童新型冠状病毒性肺炎，内因其体稚阳，正气娇弱;外因疫气秽浊，袭人尤甚，触而发之。治疗上，应以固护脾土为前提，攻补兼施;若疫气在表、胃气未败治宜清肺热兼芳香化浊，若疫病已传、损伤阳明则应清热养阴、因势利导。关键词儿童新型冠状病毒性肺炎;中医传承辅助系统;用药规律StudyonMedicationRegularityforPediatricCoronavirusDisease2019InspiredbyTCMPlagueTheoryBasedonDataMiningHUANGXiaojing，LIUZhuochao，SONGYinzhi，LINFengxia，XULuhua（ShenzhenBao′anTraditionalChineseMedicineHospitalGroupAffiliatedtoGuangzhouUniversityofChineseMedicine，Shenzhen518000，China）AbstractToexploremedicationregularityforpediatricCoronavirusDisease2019（COVID-19）inspiredbyTCMPlagueTheorythroughtheTraditionalChineseMedicineInheritanceSupportSystem（V2.5）.BycollectingtheprescriptionsforthetreatmentofpediatricepidemicsinWenbingDacheng，58completeprescriptionsthataresuitableforthetreatmentofmodernpediatricepidemicswerescreenedout，andtheprescriptionswereenteredintotheTraditionalChineseMedicineInheritanceSupportSystem，theintegratedruleanalysis，complexsystementropyclustering，unsupervisedentropyhierarchicalclusteringwereusedtosummarizethetheoreticalbasisandmedicationlawsofdoctorsinMingandQingdynastiesintreatingpediatricepidemics.Accordingtotheresultsofstatisticalanalysis，thefrequencyandassociationrulesofmedicinesfortreatingpediatricepidemicbydoctorsinMingandQingDynastieswereobtained.Finally，16coredrugcombinationswereobtained，and8newprescriptionswereextracted.TheresultsshowedthattheinternalcauseofpediatricCOVID-19isitsimmatureYangandweakvitalQi;theexternalcauseistheepidemicturbidity.Treatmentshouldbebasedoninvigoratingspleen，tonifyingandeliminatingshouldbebothapplied;iftheepidemicisonsuperficiesandthestomachQiisnotdefeated，clearinglungheatandeliminatingturbidpathogenwitharomaticsshouldbeapplied.IftheepidemicistransmittedintoYangming，nourishingYinandclearingheatshouldbeappliedtoimprovetheoccation.KeywordsPediatricCoronavirusDisease2019;TraditionalChinesemedicineinheritancesupportsystem，Medicationrule中圖分类号：R254.3;R256.19;R512.99：Adoi：10.3969/j.issn.1673-7202.2020.04.003当前，新型冠状病毒肺炎（CoronavirusDisease2019，COVID-19）[1]肆虐全球，严重威胁着人们的身心健康。儿童作为特殊的易感群体，尽管现代医学在治疗儿童COVID-19上有所突破，但受其药物剂型（如部分片剂不能捣碎）、不良作用及后遗症的影响，儿童COVID-19的西医用药仍有局限，暂无特效药[2]，故研究中医药在儿童COVID-19诊治、减少不良反应的用药规律具有重大意义及临床应用前景。中医并无COVID-19的病名，但根据其发病特点及临床症状，可将其归为“疫病”“瘟疫”。國家卫生健康委员会、国家中医药管理局发布的《新型冠状病毒感染的肺炎诊疗方案（试行第六版）》中指出，COVID-19主因感受“疫戾”之气[3]，主以“湿毒”为主，可表现为寒湿、湿热[4-8]。古代医家早已对“疫病”有所认识，尤其在明清时期，涌现了一批研究“疫病”理论的医家，如明末吴又可，...