辭囊卵黯亀IE?宫内卵硼呈中師你直2018-03-2910:29:48中国现代医生2018年5期陈静文丽红［摘耍］戸的通過超声诊断子宫内膜厚度及卵巢血液改变，探讨其在多囊卵巢综合征(polycysticovarysyndrome,PCOS)中的临床应用价值。方法选取2016年2〜12月在我院进行治疗的50例PCOS患者作为观察组，选取同期体检健康女性50例作为对照组，应用彩色多普勒超声检测两组人群的子宫内膜厚度和卵巢血液动力学变化的4项指标参数，即卵巢内收缩期峰值血流速度(peaksystolicflowvelocity,PSV)、血流指数(flowindex,Fl)、卵巢动脉阻力指数(resistanceindex,Rl)、卵巢动脉搏动指数(pulsatilityindex,PI)。再根据PCOS患者中不同停经天数分组，行上述超声检测，收集数据并比较分析。结果观察组子宫内膜厚度高于对照组，观察组PSV值明显高于对照组，而FI和PI值明显较对照组低，其差异均具有统计学意义(P均<0.05)；停经>90d组的患者与其他各停经天数组比较，子宫内膜序度和PSV值较其他停经天数组增高，RI值较其他停经天数组降低，其差异具有统计学意义(P均<0.05),而卵巢血流参数FI和PI值差异无统计学意义(P均>0.05)。结论超声技术能直观检测到PCOS患者的子宫内膜厚度增加，其卵巢动脉血液越丰富，动脉阻力越小，动脉搏动减弱，血流速度越快，为PCOS疾病的诊断和监测病情发展提供临床参考价值。［关键词］子宫内膜厚度；卵巢血液改变；超声；多囊卵巢综合征［］R730.41［文献标识码］B［］1673-9701(2018)05-0121-03［Abstract］ObjectiveToinvestigatetheclinicalapplicationvalueofultrasoundinpolycysticovarysyndrome(PCOS)throughthediagnosisofendometrialthicknessandovarianbloodchange.MethodsAtotalof50patientswithPCOSwhoweretreatedinourhospitalfromFebruarytoDecember2016wereselectedastheobservationgroupand50healthywomeninthesameperiodwerechosenasthecontrolgroup・Theendometrialthicknessandthefourindicatorsofovarianhemodynamicparameters,namelythepeaksystolicflowvelocity(PSV),bloodflowindex(Fl),ovarianarteryresistaneeindex(Rl)andovarianpulsatilityindex(PI)weredetectedbycolorDopplerultrasound.Thenaccordingtodifferentdaysofmenopause,thePCOSpatientsweregroupedandunderwenttheaboveultrasonictesting.Thedatawerecollectedandcomparativelyanalyzed・ResultsTheendometrialthicknessintheobservationgroupwashigherthanthatinthecontrolgroup・ThePSVintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup,whiletheFlandPIweresignificantlylowerintheobservationgroupthanthoseinthecontrolgroup,andthediffereneebetweenthetwogroupswassignificant(allP<0.05).TheendometrialthicknessandPSVvalueinmenopause>90daysgroupwashigherthanthatofothermenopausedaysgroups,andRlvalueinmenopause>90daysgroupwaslowerthanthatofothermenopausedaysgroups,andthedifferencewasstatisticallysignificant(allP<0.05)・WhiletherewasnosignificantdifferenceinFlandPIvalues(allP>0.05).ConclusionUltrasoundtechnologycandirectlydetecttheincreaseofendometrialthicknessinpatientswithPCOS,andthemoreabundantthebloodintheovarianartery,thesmallerthearterialresistance,theweakerarterialpulseandthefasterbloodfloAndtheultrasoundwillprovidetheclinicalreferencevalueforthediagnosisandmonitoringofPCOSdiseaseprogression.[Keywords]Endometrialthickness；Ovarianbloodchange；Ultrasound；PolycysticovarysyndromePCOS在育龄女性中是常见的影响生殖的妇科疾病之一，由内分泌系统紊乱或激素代谢异常使相应激素通过与受体结合的信号通路将其传导入靶细胞，导致靶器官卵巢和子宫发生一系列病理变化，引起排卵困难甚至不孕、胰岛功能异常、原发性肾上腺功能障碍等疾病⑴。有学者认为PCOS与子宫内膜厚度密切相关，子宫内膜容受性差影响子宫内膜基底层牛.长发育，使其厚度异常增牛・。同时，PCOS可激活卵巢内血管内皮因子(vascularendothelialfa...