不对称二甲基精氨酸在冠心病临床分型中的应用中南大学学版)2o1o,35(4)http://xhyx.ysm.nelJCentSouthUnivMedSci)"......................301CorrelationbetweenplasmaasymmetricdimethylarginineanddifferenttypesofcoronaryheartdiseaseCAOYu,YANGKan,ZHANGZhihui,OUYANGMao,XIAOLi(DepartmentofCardiology,ThirdXiangyaHospital5CentralSouthUniversity>Changsha410()13,China)Abstract:ObjectiveTomonitorthechangesofplasmaasymmetricdiinethylarginine(ADMA),nitricoxide(NO),andvonWi!lebrandfactor(vWF)levelsinpatientswithstableanginapectoris(SAP)oracutecoronarysyndrome(ACS)andtoevaluatethecorrelationbetweenADMAanddifferenttypesofcoronaryheartdisease.MethodsAtotalofl43subjectsweredividedintoanon一CHDgroup.aSAPgroupandanACSgroup.PlasmalevelsofADMA.NOandVWFwereexaminedancltheircorrela—tionwithSAPorACSwasanalyzed.ResultsComparedwiththenon—CHOortheSAPgroup,ADMAlevelwaselevatedintheACSgroup(P<0.05).TheADMAleveltendedtoincreaseintheSAPgroupcomparedwiththenon一CHDgroup,buthadnosignificantdifference(P>0.05).ComparedwiththenonCHDgroup,NOlevelwasdccrcasedinboththeSAPandACSgroup(P<0.05),anditdecreasedmoreinACSgroupthanthatintheSAPgroup(P<0・05);vwFlevelswereinoreasedinboththeSAPandACSgroupcomparedwiththenon-CHDgroup(P<0.05).TherewasnosignificanulifferenceintheplasmalevelsofvWFintheSAPandtheACSgroup(P>0.05).ConclusionThechangeofplas—maADMAleveliscloselycorrelatedwithacutecoronarysyndrome.ADMAmightbeaclinicalmarkerforacutecoronarysyndrome.Keywords:asymmetricdimethylarginine;nitricoxide;coronaryheartdisease;acutecoro一narysyndrome不对称二甲基精氨酸在冠心病临床分型中的应用曹宇，杨侃，张志辉,欧阳茂，肖丽(中南大学湘雅三医院心血管内科，长沙410013)［摘要］冃的:测定冠心病患者中稳定型心绞痛和急性冠脉综合征的血浆不对称二甲基精氨酸(ADMA)-氧化氮(NO)和血管性血友病因子(vWF)水平，探讨其与冠心病各临床类型之间的关系.方法:按纳入与排除标准入选了143例研究对彖,其中包括非冠心病组64例，急性冠脉综合征组54例和稳定性心绞痛组25例•检测各组血浆ADMA,NO和vWF水平，并分析它们与急性冠脉综合征和稳定性心绞痛之间的相关性.结果:与非冠心病组和稳定型心绞痛组比较，急性尅脉综合征血浆ADMA水平显着升高(P<0.05).与非冠心病组相比,稳定型心绞痛组血浆ADMA水平有升高趋势但差异无统Dateofreception2009------06一-02BiographyCAOYu,masterdegree,mainlyengagedintheinterventionalcardiologyandpathogenesisofcoronaryheartdiseaseCorrespondingauthorXIAOLi,E-mail:caoyuxiaoli@hotmail.con中南大学(医学版),2010,35(4)http://xbyx.xysm.net计学意义(尸>0.05);与非冠心病组相比，稳定型心绞痛和急性冠脉综合征组血浆NO水平均显着下降(P<0.05),急性冠脉综合征组下降的程度明显大于稳定型心绞痛组(P<0.05);与非冠心病组相比,稳定型心绞痛组和急性冠脉综合征组血浆vWF水平均显着升高(P<0.05).稳定型心绞痛组和急性冠脉综合征组之间血浆vWF水平差异无统计学意义(P>0.05).结论:血浆ADMA水平变化与冠心病中急性冠脉综合征的发生发展密切相关，血浆ADMA水平的变化可能是急性冠脉综合征的预测因子.［关键词］不对称二甲基精氨酸;一氧化氮;冠心病;急性冠脉综合征DOI:10.3969/j.issn.1672—7347.2010.04.004Endothelium一derivednitricoxide(NO),whichpossessesvariousbiologicalpropertiessuchasanti一oxidation.anti-inflammationandanti一apopto・sis.playsanimportantroleinmaintainingtheinteg一rityofbloodvesselendotheliumandpreventingthedevelopmentofatherosclerosis.Inthedevelopmentofcoronaryheartdisease(CHD),impairedfunctionofbloodvesselendotheliumiscloselyrelatedtothede一clineofNOlevelinplasma.ThegenerationofNOisfromL一argininecatalyzedbyNOsynthases(NOS).R...