不稳定型心绞痛患者冠脉循环与周围血中纤维蛋白原和D-二聚体的变化内蒙古医学杂志InnerMongohaMedJ2007年第39卷第3期285[3]黄素芳,孟祥春,于丽君,等.d,JD病毒性肺炎的病毒病原学分析[J].哈尔滨医科大学,2001,35(4):286.[4]AndreolettiL,Le~ayM,DesehildreA,eta1.DifferentialdetectionofrhinovirusesandenterovirusesRNAsequencesassociatedwithclassicalimmunofluorescenceassaydetectionofrespiratoryvirusantigensinnasopharyngealswabsfrominfantswithbronchiolitis[J].JMedvirol,2000,61(3):341.[5]JarrtiT.LehtinenP,VuofinenT,eta1.Respiratorypiocomavirusesandrespiratorysyncytialvirusascausativeagentsofacuteexpira—torywheezinginchildren[J].EmergInfectDis,2904,10(6):不稳定型心绞1095.[6]王小稳.急性下呼吸道感染病原学分析[J].实用儿科临床杂志,2004,19(7):601.[7]吴珉,王子才,顾彬,等.肺炎3种病毒病原检测及分析[J].实用儿科临床杂志,2005,20(7):677.【收稿日期]2006—06一Ol【作者简介]姚丽萍(1968一),女,山西省原平县人.医学硕士,副主任医师,副教授.研究方向为小儿呼吸,循环系统疾病.痛患者冠脉循环与周纤维蛋白原和D一二聚体的变任爱平,陈宁,王蒙琴,杨叶围血中化(包头医学院第一附属医院急诊科,内蒙古包头014010)[摘要]目的:了解不稳定型心绞痛(UAP)患者冠脉循环和周围血中纤维蛋白原(Fg)和D一二聚体(DD)的变化.方法:选32例UAP患者和10例冠脉造影无狭窄的正常人为研究对象.在做冠脉造影时同时采集冠状静脉窦(CS),主动脉根部(A0)和上腔静脉(SVC)血,测定DD和Fg含量.结果:UAP患者CS中Fg和DD含量均比正常人高.正常人和UAP患者三部位Fg,DD测定结果无明显差异.在心绞痛发病当时采血的UAP患者Fg,DD含量明显高于平均值,其CS中Fg含量比AO中低,DD含量比A0中高.结论:UAP患者存在凝血,纤维功能凝血的失调.UAP患者在心绞痛缓解后,冠脉循环中凝血,纤维状态与全身循环血中一致.心绞痛发作时,冠状动脉内有血栓生成并伴有纤溶活性改变.[关键词]不稳定型心绞痛;纤维蛋白原;D一二聚体【中图分类号]R541.42【文献标识码]A【论文编号]1004.0951(2006)03—0285.03TheChangesofFibrinogenandD—DimerinGeneralCirculationandCoronaryCirculationofPatientsWithUnstableAnginaPectorisRenAi—ping,ChenNing,WangMeng?qin,YANGYe(DepartmentofEmergency,TheAffiliatedHospitalofBaotouMechicalCollege,Baotou014010China)[Abstract]Objeetive:ToassessthechangesofD—Dimer(DD)andfibrinogen(Fg)inperipheralbloodandcoronarycirculationofunstableanginapectoris.Methods:32UAPpatientsand15controlsubjectswitharterio.graphicallynormalcoronaryarterieswerecollectedsimulteaneouslyfromcoronarysinus(cs),aorticroot(A0),andsuperiorvenacava(SVC)whilecoronaryarteriographyperformed.plasmaDDandFgwereanalyzed.Rrsults:ThelevelsofDDinCS.AO,andSVCwerehigerthanthatofcontrolsubjects.AlltheseprofilesdidnotdifferinCS,AO,andSVC,eitherUAPpatientsorcontrolsubjects.PlasmaconcentrationofFginCSofUAPpatientswhowerehavinganginapectoriswhilesampleswithdrawnwerelower,andplasmaconcentrationofDDwashigherthanthatinAO.Conclusion:ThedisorderofcoagulationandfibrinolysisplaysanimportantroleinthepathogenesisofUAP.Afteracutephase,thestateofcoagulationandfibrinolysisinthecoronarycirculationofUAPpatientsissimilartothatinperipheralblood,thatis,peripheralbloodsamplesmayadequatelyreflecttheactivityofthesemarkersincoronarycirculation.[Keywords]Untableanginapectoris;Fibrinogen;D—Dimer不稳定型心绞痛(UAP)是介于稳定型心绞痛()和急性心肌梗塞(AMI)之间的一组冠状动脉286内蒙古医学杂志InnerMongoliaMedJ2007年第39卷第3期急性缺血症候群.不稳定型心绞痛易发展为AMI和猝死.探讨UAP发病机制,预防和控制不稳定型心绞痛已成为医学界的重大课题.目前认为心绞痛的不稳定性多数与冠状动脉内斑块破裂,血小板聚集,血栓形成和冠状动脉痉挛等因素有关【1....
