Abouttheimpactoflow-intensitypulsedelectromagneticfieldsonbonemineraldensityandbonehistomorphometryAuthor:XuQiaolingRoadLihuaFORCESINSOUTHWESTLiuDonghuan,beforeJaneWuXiaomingLiLirong[Keywords]histomorphometry[Abstract]AIM:Toinvestigatetheeffectsofpulsedelectromagneticfields(PEMFs)onbonemineraldensity(BMD)andhistomorphometryinovariectomizedrats.METHODS:ThirtytwofemaleSDratsweredividedrandomlyinto4groups:ovariectomy,control,magneticA,magneticB.Alltheratswereoperatedontheabdomenandtheratsofovariectomygroupandmagneticgroups(A,B)wereovariectomized.Theratsofcontrolgrouponlyhadshamoperationandwerenotovariectomized.Theratsinbothmagneticgroupswereexposedto15HzPEMFs6hoursperday,withitspulsedurationsetto5ms.MagneticgroupAandgroupBwereexposedtoPEMFswithdifferentmagneticintensity,4×10-4TforgroupAand8×10-4TforgroupB.Alltheanimalswerekilled8weeks1afteroperationandthechangesofBMDandhistomorphometricpropertieswereobserved.RESULTS:Thevalues&#8203;&#8203;ofBMD,trabeculararea,trabecularthicknessandtrabecularnumberinovariectomizedgroupsignificantlydecreased,comparedwiththoseoftheotherthreegroups(P<0.05),whilethetrabecularseparationinovariectomizedgroupincreasedobviously,comparedwithmagneticgroupAandmagneticgroupB(P<0.05.Comparedwiththoseofcontrolgroup,nosignificantdifferenceswerefoundinthevalues&#8203;&#8203;oftotalbodyBMD,trabecularareaandtrabecularnumberinmagneticgroupB(P>0.05.But,statisticallysignificantdifferenceswereobservedinthevalues&#8203;&#8203;oftotalbodyBMDandtrabecularnumberbetweenthetwomagneticgroups(P<0.05.CONCLUSION:Therearesomeevident“windoweffects“duringthetreatmentbyPEMFs.PEMFsareeffectiveinimprovingBMDandhistomorphometricvalues&#8203;&#8203;andarefavorabletothetreatmentandpreventionofosteoporosis.2[Keywords]pulsedelectromagneticfields;osteoporosis;bonemineraldensity;bonehistomorphometry[Abstract]Objective:Toinvestigatetheimpactoflow-intensitypulsedelectromagneticfieldsonbonemineraldensityandbiomechanicalproperties.:323mo-oldfemaleSDratswererandomlydividedintofourgroups(n=8:castrationgroup,thecontrolgroupmagneticfieldgroupA,themagneticfieldBgroup,theratsareusedincisioninthelowerabdomen,thecastrationgroupandmagneticfieldgroupbilateraloophorectomy,thecontrolgrouponlyunderwentlaparotomy.magneticfieldAgroupexposedtothestrengthof4×10-4Tpulsedmagneticfieldenvironment,themagneticfieldBgroupexposedonthestrengthof8×10-4Tpulsedmagneticfieldenvironment,thetwosetsofmagneticfieldfrequencyfare15Hz,aτfor5msviolencemagnetic6h/d.theanimalfeedingconditions,werekilledafter8wkmeasuredwholebodybonemineraldensityandbonehistomorphometry.Results:ComparedwiththeOVXgroup,bodybonemineraldensityofthemagneticfieldgroup,bonemineraldensityinthedistalfemur3percentageoftrabecularbonearea,trabecularwidth,trabecularnumberwereincreased(P<0.05,thetrabecularbonegapdecreases(P<0.05,whilecomparedwiththecontrolgroup,thebodybonemineraldensityofthemagneticfieldBgroup,bonesmallthereisnodifferencebetweenthebeamareapercentageandthenumberoftrabecularindicatorssignificantlysignificance(P>0.05,forcomparisonbetweenthetwomagneticfieldgroup,wholebodybonemineraldensityandtrabecularnumberwassignificantlydifferent(P<0.05.conclusion:PEMFsonovariectomizedratosteoporosisoccurrenceofcertainpreventiveandtherapeuticeffects,andmagneticfieldbiologicaleffectsobviouswindoweffects.[Keywords:pulsedelectromagneticfields,osteoporosis...