About Chinese medicine Xiaoweiling on rats with chronic atrophic gastritis gastric mucosal blood flow and plasma stomach motilin（关于中药Xiaoweiling对慢性萎缩性胃炎大鼠胃黏膜血流量和血浆胃胃动素）

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AboutChinesemedicineXiaoweilingonratswithchronicatrophicgastritisgastricmucosalbloodflowandplasmastomachmotilinTowritethesisnet:Author:XiaobinZhangZhonghaiEMERGENCYofWangLiuGuochengChapterBeechamYangDiscoverysummerGastricprecancerouslesions[words]Keywords:Xiaoweiling;chronicatrophicgastritis;precancerouslesions;gastricmucosalbloodflow;plasmamotilinAbstract:ObjectiveToobservetheherbalcompoundXiaoweilingratswithchronicatrophicgastritis(CAGandprecancerouslesions(PLGCanimalmodelofgastricmucosalbloodflow(GMBFandplasmastomachmotilin(MTLanditspathologicalreversaltreatmenteffectmethodinaftertosuccessfulratCAGPLGCanimalmodelusinglaserDopplermeterratCAGandthePLGCtheGMBFwasmeasuredbyradioimmunoassayplasmaMTLcontent,andcomparisonbetweendifferentgroups,whilegroupsCAGPLGCpathologicalmicroscopicexaminationresultstocompareresultsofmodelgroup1thannormalgroupgastricmucosalbloodflowwassignificantlylower(6.91+-0.72→4.46+-0.71,P<0.05,highXiaoweiling,thelow-dosegroupandWeimeisugroupGMBFwassignificantlyimproved(0.34±0.31,6.55+-0.89,5.58+-0.68(P<0.05)highXiaoweiling,low-dosegroupwerebetterthanWeimeisugroup(P<0.05),thehighdosegroupofXiaoweilingclosetothelevelofthenormalgroup(P>0.05;themodelgroupMTLthannormalgroupsignificantlyreduced(84.3+-4.2,86.9±4.3,94.7+-7.1,P<0.05,highXiaoweiling,betweenlowdosenosignificantdifferences,andarebetterthantheWeimeisugroup(P<0.05ofXiaoweilinghighdosegroup,pathologicalmicroscopicexaminationoftheresultsofthelow-dosegroupwassignificantlybetterthanWeimeisugroup(P<0.05.ConclusionChinesemedicineXiaoweilingcanimprovetheCAGandPLGCratsGMBFandreducethelevelofitsabnormallyhighlevelsofplasmaMTL,improvetissuepathology,andprovideanexperimentalbasisfortheXiaoweilingtreatmentCAGandPLGC.Keywords:Xiaowelin;chronicatrophicgastritis;precancer-ouslesionsofgastriccancer;gastricmucosia2bloodflows;plasmamotilinAbstract:AIMToexploretheeffectsofXiaoweilinonGMBFandMTLinratswithatrophicgastritisandprecan-cerouslesionsofgastriccancerandtostudyitstherapeuticef┐fects.METHODSAcomplexmethodwasusedtoestablishthemodelthatwasstimulatingthevariousfactorstocausethePLGC.GMBFweremeasureddirectlybylaserdopplerflowmeter.Thedataofdifferentgroupswereanalyzedandcomparedwitheachother;theirhistopathologicchangeswerealsocompared.RESULTSInthemodelgroup,theGMBFdecreased(6.91+-0.72→4.46+-0.71,P<0.05whiletheMTLincreased(8.16±9.2→10.17+-6.3,P<0.05.Xi-aoweilinhigh,lowdosetherapygroupandWeimeisutherapygroupincreasedtheGMBF(0.34+-0.31,6.55+-0.89,5.58+-0.68,P<0.05butdecreasedtheMTL(84.3+-4.2,86.9+-4.3,94.7+-7.1,P<0.05,andtheXiaoweilinhighdosetherapygroupandXiaoweilinlowdosetherapygroupwerebothbetterthantheWeimeisutherapygroup(P<0.05).TheGMBFofXiaoweilinhighdosetherapygroupwerenomorethanthecontrolgroup(P>0.05,andthehistopathologic3changesoftheXiaoweilinhigh,lowdosetherapygroupswerebothbetterthanthoseoftheWeimeisutherapygroup(P<0.05.CONCLUSIONTheexperimen-talPLGChavelowerGMBFandhigherMTL.Xiaoweilincanmodulatethisstateandimprovethevariouspathologicalman-ifestationsofCAGandPLGC.0IntroductionWeobservedXiaoweilingapplicationofChinesemedicineinpreventionofchronicatrophicgastritis(chronicat-rophicgastritis,CAGistheadvantageofChina’spharmaceutical[1].Xiaoweilingbloodcirculation,EndometriosisefficacyoftreatmentCAGefficacy.TheratsCAGandprecancerouslesions(PLGCgastricmucosa(GMBFandplasmamotilin(MTLimpact.1Materialsandmetho...

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