CephradineCapsulescausedbytherelease-typedrugeruptionbullousepidermalnecrolysisonecasesAuthor:WangChengboWangli激ng激angXiaodong[Keywords:]cephalosporinPatients,female,54yearsold.TonsillitisoralCephradineCapsules(ShandongZiboPharmaceuticalCo.,Ltd.productionof500mgofeach,fourdailyfor4daysafterthetrunkofanumberofmiliarypapuleswithitching,stopmedicine,oralchlorpheniramine,prednisoneandothermedications,therashsubsided.3monthsafter2haftertakingthisdrugbecauseoftonsillitisdistallimbserythema,burning,andquicklyspreadtothetrunk,limbs,andflaccidbullaeandblisters,ulcerationaftertheformationoflargeareasoferosion,necrosis,andexudate.previouslyhealthyandhavenohistoryofinfectiousdiseasesandallergyhistory,familygenetichistory.Physicalexamination:T-38.6°C,P88min-1,R20min-1,BP18.5/11.0kPa.clearconsciousness,sufferingface.Dermatology:mildconjunctivalhyperemia,torso,limbs,skinshowsdarkred---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---anddarkredstainfilms,ofvaryingsizes,eachfusiononpeanutstolargeovalblister,theblisterfluidisclear,theblisterwallisthinandrelaxation,likescaldedNisslpositivesigns,bilateralaxillary,back,buttocksandvulva,vastusmedialislargeareasoferosion,serousexudate,localtenderness.laboratorytests:WBC7.6×109/L,N0.80L0.18,M0.02,ESRof5mm/1h,electrolytes,liverfunctionwerenormal.diagnosis:bullousepidermalnecrolysisreleasetypedrugeruption.admissiongivendexamethasone30mg+50g/Lglucoseinjection500mLofintravenousinfusion,atthesametimepluserythromycinresistancetoinfection,theGIKenergytoprotecttheliverandkidneyfunction,adjustingtheacid,alkalinebalanceandcorrectthewater,electrolyteimbalance.moreexudateoflesionswith30g/Lboricacidliquid-cooledwetcompress,2g/Loflocalgentamicinspray.12d,bodytemperaturereturnedtonormal,necroticepidermiscompletelyoff,trunk,stillredandswollenlimbs.pain,dryskin,thistimecreamtopicalhepudiod(themaincomponentofheparin,oralastemizole3mg/dtoreduceglucocorticoiddosage.30dafterskinlesionssubsided,leavingareddish-brown---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---hyperpigmentation,laboratorytestseachindexisnormal.hospital35daysanddischarged.discussionbullousepidermalnecrotizingreleasedrugeruptionisthemostimportanttypeofdrugeruption,commonallergenicdrugshaveantipyreticanalgesics,sulfonamides,hypnotics,sedatives,andantibioticstheclass.thiscase,symptomstypicalofasingledrug,acleardiagnosisofthepatientsduetotonsillitisthepullfromtheclothescephalosporincapsulesforthefirsttimearash,mildsymptoms,takinganti-histaminedrugrashquicklydissipated,anddidnotattractenoughattention.threemonthslateraheavydrugeruptionduetotonsillitistakingsuchdrugs,thecliniciansinthemedicalhistoryshouldbeaskedindetailaboutthehistoryofdrugallergy,andtoavoidtheoccurrenceofheavydrugeruptionpatientspreferredglucocorticoidtreatment,inprinciple,earlylarge-scaleapplicationavoidtheuseofethanol-containingglucocorticoidssuchashydrocortisone,followedbythefollowingmeasures:resistancetoinfectionandtopreventsecondaryinfectionandmaintainwaterandelectrolyteandacid-basebalance,strengthenthelocalcareofthelesion.Sharethe---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---freepaperDownload://eng.hi138---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---