奥扎格雷钠联合疏血通治疗急性脑梗死疗效评价及对血清TNF-a.I摘要目的：探究奥扎格雷钠联合疏血通治疗急性脑梗死的临床疗效及对患者血清TNF-a、IL-6和hs-CRP水平的影响。方法：回顾性分析2013年1月”2015年6月我院收治的急性脑梗死患者72例，根据治疗方式的不同，分为研究组38例和对照组34例。对照组给予脱水降压、抗血小板凝聚、脑细胞保护及对症支持等常规治疗及奥扎格雷氯化钠注射液治疗，研究组在对照组的基础上加用疏血通注射液。比较两组患者的临床疗效、不良反应以及治疗前后血清TNF-a、IL-6和hs-CRP水平的变化。结果：研究组治疗的总有效率和ADL评分为84.21%和(78.43&plusmn；8.75)分，对照组为67.64%和(66.54&plusmn；10.12)分(P&lt；0.05)；研究组治疗7d、14d后血清TNF-&alpha；、IL-6及hs-CRP的含量分别为(2.21&plusmn；0.36)ng/L和(1.86&plusmn；0.44)ng/L、(54.75&plusmn；3.25)pg/L和(42.36&plusmn；3.62)pg/L及(7.53&plusmn；3.22)mg/L和(3.19&plusmn；1.90)mg/L,而对照组分别为(2.63&plusmn；0.42)ng/L和(2.14&plusmn；0.39)ng/L、(60.61&plusmn；3.69)pg/L和(55.73&plusmn；3.16)pg/L及(10.46&plusmn；3.41)mg/L和(6.23&plusmn；2.94)mg/L(P&lt；0.05)o结论：奥扎格雷钠联合疏血通治疗急性脑梗死疗效确切，不良反应少，且还能显著降低急性脑梗死患者血清TNF-a.IL-6和hs-CRP水平，抑制患者机体内的炎症反应。关键词奥扎格雷钠疏血通急性脑梗死血清细胞因子中图分类号：R743.33；R286文献标识码：B文章编号：1006-1533(2016)17-0028-03EvaluationoftheefficacyofsodiumozagrelcombinedwithShuxuetonginjectioninthetreatmentofacutecerebralinfarctionandtheireffectonserumTNF-&alpha；,IL-6andhs-CRPlevels*LIWen,CAIZhongping,LAOWencheng(DepartmentofInternalMedicine,AgriculturalReclamationSecondHospitalofZhanjiangCity,GuangdongProvince,Zhanjiang524272,China)ABSTRACTObjective：ToexploretheclinicalefficacyofsodiumozagrelcombinedwithShuxuetonginjectioninthetreatmentofacutecerebralinfarctionandtheireffectonserumTNF-&alpha；,IL~6andhsCRPlevels・Methods:Seventy-twocasesofpatientswithacutecerebralinfarctionwereretrospectivelyanalyzedanddividedintoastudygroup(38cases)andacontrolgroup(34cases)basedonthedifferencesofthetreatmentmethods・Thecontrolgroupwastreatedbyconventionaltreatmentsincludingdehydration,antihypertension,anti-plateletaggregation，protectionofbraincells,symptomaticandsupportivetreatmentandozagrelwhilethestudygroupwithShuxuetonginjectiononthebasisofthecontrolgroup・TheclinicalefficacyandadversereactionsandthechangesofserumTNF-&alpha；,IL~6andhs-CRPlevelswerecomparedbetweentwogroups・Results：ThetotaleffectiverateandADLscoreswere84.21%and(78.43+8.75)inthestudygroupand67.64%and(66.54+10.12)inthecontrolgroup(P&lt；0.05)・ThecontentsofserumTNF-alpha,IL~6andhs-CRPwere(2.21+0.36)ng/Land(1.86+0.44),(54.75&plusmn；3.25)pg/Land(42.36&plusmn；3.62)pg/Laswellas(7.53&plusmn；3.22)mg/Land(3.19&plusmn；1.90)mg/Linthestudygroupand(2.63&plusmn；0.42)ng/Land(2.14&plusmn；0.39)ng/L,(60.61&plusmn；3.69)pg/Land(55.73&plusmn；3.16)pg/Laswellas(10.46&plusmn；3.41)mg/Land(6.23&plusmn；2.94)mg/Linthecontrolgroup7and14daysaftertreatment,respectively(P&lt；0.05)・Conclusion：TheclinicalefficacyofsodiumozagrelcombinedwithShuxuetonginjectioninthetreatmentofacutebraininfarctionisclear.TheypossesslessadversereactionsandcansignificantlyreducetheserumTNF-&alpha；，IL~6andhs~CRPlevelsandinhibittheinflammatoryreactioninpatients・KEYWORDSsodiumozagrel；Shuxuetong；acutecerebralinfarction；serumcytokine近年来，急性脑梗死的发病率呈日益增长的趋势，加之急性脑梗死的高致残率和高死亡率，已引起广大临床医师的高度关注。...