两种方法治疗HAART后血脂异常的疗效对比研究苏齐鉴：梁飞立2,李益忠-邓鑫I,邓梅花彳，张亚萍I(1•广西中医药大学附属瑞康医院艾滋病研究中心，广西南宁530011;2•广西横县人民医院感染科，广西横县530300)［摘要］目的对比绞胶蓝总戒片联合山楂精降脂片与阿托伐他汀钙片治疗HAART后血脂异常的疗效。方法将60例HAART后血脂异常患者按2:1的比例随机分至试验组和对照组。试验组给予绞胶蓝总戒片和山楂精降脂片；对照组给予阿托伐他汀钙片，服药6周。检测服药前后血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C).高密度脂蛋白胆固醇(HDL-C)和载脂蛋白Al(APOA1)和载脂蛋白B(APOB),比较两组各指标治疗前后差值和总有效率。结果治疗后，试验组TC下降(0.26+0.59)mmoHALDL-C下降(0.13+0.58)mmol<L-1,对照组TCW(0.83±0.84LDL-C下降(0.69±0.94)mmobL1,两指标的组间差异均有显著性意义(P<0.05),其余指标前后差值的组间差异均无显著性意义；试验组总有效率为72.50%,对照组总有效率为100%,差异有显著性意义(P<0.05)。结论绞胶蓝总竄片联合山楂精降脂片可改善血脂，但疗效不及阿托伐他汀钙片。［关键词］艾滋病；高效抗逆转录病毒治疗(HAART);血脂异常;绞胶蓝总戒片；山楂精降脂片；阿托伐他汀钙片［中图分类号］R589.2;R512.91［文献标识码］AAcomparativestudyonefficacyoftwodifferentregimensinthe基金项目：广西壮族自治区卫生厅中医药科技专项(GZKZ10-065)；广西中医药大学附属瑞康医院重点课题(RKZ201004)*副研究员。研究方向:艾滋病防治。电话：0771-2238022cE-maikagansue@l63.corntreatmentofpatientswithHAART-associateddyslipidemiaSUQi-jian1,LIANGFei-li2,LIYi-zhong1,DengXing1,DengMei-hua2,ZhangYa-ping1.(1.CenterforAIDSResearch,theAffiliatedRuikangHospital,GuangxiUniversityofChineseMedical,Nanning530011,China;2.Dept,ofinfectiousdiseases,People'sHospitalofHengxianCountyofGuangxiautonomousregion,Hengxian530300,China)[Abstract]ObjectiveTocomparetheclinicaleffectsofJiaogulanzongdaiTabletscombinedwithShanzhajingTabletsandAtorvastationCalciumTabletsonHAART-associateddyslipidemia.Methods60patientswithHAART-associateddyslipidemiawererandomlydividedintotheexperimentalgroupandthecontrolgroupattheratioof2:1.AllpatientsintheexperimentalgroupweregivenJiaogulanzongdaiTabletscombinedwithShanzhajingTabletsfor6weeks,andpatientsinthecontrolgroupweregivenwithAtorvastationCalciumTablets.Serumtotalcholesterol(TC),triglyceride(TG),low-densitylipoproteincholesterol(LDL-C),high-densitylipoproteincholesterol(HDL-C),apolipoproteinAl(APOA1),andapolipoproteinB(APOB)weredetectedbeforeandafterthetherapy.Then,thelipidchangesaftertherapyandtheclinicalefficacybetweentwogroupswerecompared.ResultsAftertherapy,theexperimentalgrouphadadecreaseof(0.26±0.59)mmobL'1inTC,andadecreaseof(0.13±0.58)mmohL1inLDL・C,comparedwithadecreaseof(0.83±0.84)mmobL'1inTCandadecreaseof(0.69±0.94)mmol*L1inLDL-Cinthecontrolgroup・ThereweresignificantdifferencesinTCandLDL-Cchangesbetweenthetwogroups(P<0.05),butnotforotherlipidchanges・Theexperimentalgrouphada72.50%overallefficacy,comparedwith100.00%ofthecontrolgroup(Pv0・05).ConclusionJiaogulanzongdaiTabletscombinedwithShanzhajingTabletsiscapableofimprovingbloodlipidprofiles,butisinferiortoAtorvastationCalciumTablets.[Keywords]AIDS;Highlyactiveantiretroviraltherapy(HAART);Dyslipidemia;JiaogulanzongdaiTablet;ShanzhajingTablet;AtorvastationCalciumTablet血脂异常是脂肪代谢或运转异常所致的血液中一种或几种脂质浓度异常，其特征为总胆固醇、低密度脂蛋白胆固醇、甘油三酯升高,和/或高密度脂蛋白胆固醇低下⑴2】。在接受高效抗逆转录病毒治疗(highlyactiveantiretroviraltherapy,HAART)的艾滋病患者中,血脂异常...