米非司酮联合米索前列醇用于瘢痕子宫中期妊娠引产临床效果观察[摘要]目的探索米非司酮联合米索前列醇用于瘢痕子宫中期妊娠引产临床效果。方法选取2015年5月～2016年5月我院收治的100例瘢痕子宫中期妊娠引产患者作为研究对象，将其抽签化分为两组，，每组各50例。对照组采用经腹壁行羊膜腔注射治疗，观察组采用米非司酮联合米索前列醇治疗。比较两组患者的并发症发生率、胎盘残留率、出血量、引产成功率、用药至宫缩发动时间、宫缩至胎儿胎盘娩出时间、用药至胎儿胎盘娩出时间。结果观察组患者的用药至宫缩发动时间[（27.69±3.52）h]、宫缩至胎儿胎?P娩出时间[（8.52±1.44）h]、用药至胎儿胎盘娩出时间[（34.53±3.95）h]短于对照组[（35.86±5.86）h，（11.32±2.56）h，（48.91±5.22）h]，差异有统计学意义（P<0.05）。观察组患者的胎盘残留率（4.00%）低于对照组（30.00%），出血量[（142.74±25.98）ml]少于对照组[（159.86±36.85）ml]，引产成功率（98.00%）高于对照组（76.00%），差异均有统计学意义（P<0.05）。观察组患者的并发症发生率（2.00%）低于对照组（26.00%），差异有统计学意义（P<0.05）。结论对瘢痕子宫中期妊娠引产患者实施米非司酮联合米索前列醇治疗，能够提高引产成功率，降低治疗风险性。[关键词]米非司酮；米索前列醇；瘢痕子宫；引产[]R169.42[文献标识码]A[]1674-4721（2017）10（c）-0076-03ObservationtheclinicaleffectofMifepristonecombinedwithMisoprostolininductionoflaborinthemiddletrimesterofscaruterusAIDan1ZHONGLi-zhen21.DepartmentofReproductiveHealth，激angxiMaternalandChildHealthCareHospital，Nanchang330006，China；2.Outpatient，激angxiMaternalandChildHealthCareHospital，Nanchang330006，China[Abstract]ObjectiveToinvestigatetheclinicaleffectofMifepristonecombinedwithMisoprostolininductionoflaborinthemiddletrimesterofscaruterus.Methods100inductionoflaborinthesecondtrimesterofscaruteruspatientsfromMay2015toMay2016treatedinourhospitalwereselectedasobjects.Patientsweredividedintotwogroupsaccordingtolotterymethod，andeachgroupwas50cases.ThecontrolgroupandobservationgroupwererespectivelygiventreatmentofabdominalwallwithamnioticMembraneInjectionandMifepristonecombinedwithMisoprostol.Twogroupsofpatientswithcomplications，placentalresidualrate，bleedingvolume，successfulrateofinducedlabor，durationofmedicationtocontractionsstarttime，thecontractionstothefetalplacentaldeliverytime，deliverytimetothefetalplacentawerecompared.ResultsObservationgroupofpatientswithdurationofmedicationtocontractionsstarttime[（27.69±3.52）h]，thecontractionstothefetalplacentaldeliverytime[（8.52±1.44）h]，deliverytimetothefetalplacenta[（34.53±3.95）h]wereshorterthanthoseinthecontrolgroup[（35.86±5.86）h，（11.32±2.56）h，（48.91±5.22）h]，thedifferenceswerestatisticallysignificant（P<0.05）.Placentalretentionrateofthepatientsinobservationgroup（4.00%）waslowerthanthecontrolgroup（30.00%），thebleedingvolumeofthepatientsinobservationgroup[（142.74±25.98）ml]waslessthanthecontrolgroup[（159.86±36.85）ml]，thesuccessrateofinducedlabor（98.00%）washigherthanthecontrolgroup（76.00%），thedifferenceswerestatisticalsignificance（P<0.05）.Theincidenceofcomplicationsintheobservationgroup（2.00%）waslowerthanthecontrolgroup（26.00%），andthedifferencewasstatisticallysignificant（P<0.05）.ConclusionMifepristonecombinedwithMisoprostolinthetreatmentofinducedabortioninthemiddletrimesterofscaruteruscanimprovethesuccessrateofinducedlaborandreducetheriskoftreatment.[Keywords]Mifepristone；Misoprostol；Scaruterus；Inductionoflabor瘢痕子宫可随着剖宫产发生率逐渐上升，其流产风险...