没有任何一条途径在细胞的某种反应中是独立存在的,每条途径都可以和许多其他途径相整合,它们的强度、相互作用、整合结果决定了细胞的命运。5参考文献1AlmogT,NaorZ.Mitogenactivatedproteinkinases(MAPKsasregula-torsofspermatogenesisandspermatozoafunctions〔J〕.MolecularCel-lularEndocrinology,2008,282(1-2:392PerryAC,VerlhacMH.Secondmeioticarrestandexitinfrogsandmice〔J〕.EMBORep,2008,9(3:2463LeeSE,KimJH,KimNH,etal.InactivationofMAPKaffectscentro-someassembly,butnotactinfilamentassembly,inmouseoocytesma-turinginvitro〔J〕.MolReprod,2007,74(7:9044FanHY,LiuZ,ShimadaM,etal.MAPK3/1(ERK1/2inovariangranulosacellsareessentialforfemalefertility〔J〕.Science,2009,324:9385MotolaS,CaoX,PoplikerM,etal.Involvementofmitogen-activa-tedproteinkinase(MAPKpathwayinLH-andmeiosis-activatingsterol(MAS-inducedmaturationinratandmouseoocytes〔J〕.MolReprodDev,2008,75(10:15336ShaulYD,SegerR.TheMEK/ERKcascade:fromsignalingspecificitytodiversefunctions〔J〕.BiochimBiophysActa,2007,1773(8:12137GonzálezR,Ruiz-LeónY,GomendioM,etal.Theeffectofglu-cocorticoidsonERK-1/2phosphorylationduringmaturationoflambo-ocytesandtheirsubsequentfertilizationandcleavageabilityinvitro〔J〕.ReprodToxicol,2010,29(2:1988RussoC,BeaujoisR,BodartJF,etal.KickedbyMOSandtunedbyMPF-theinitiationoftheMAPKcascadeinxenopusoocytes〔J〕.HF-SPJ,2009,3(6:4289AmielA,LeclèreL,RobertL,etal.ConservedfunctionsforMOSineumetazoanoocytematurationrevealedbystudiesinacnidarian〔J〕.CurrBiol,2009,19(4:30510VerlhacMH,LefebvreC,KubiakJZ,etal.MOSactivatesMAPki-naseinmouseoocytesthroughtwooppositepathways〔J〕.EMBOJ,2000,19(22:606511MadgwickS,JonesKT.HoweggsarrestatmetaphaseII:MPFstabilisationplusAPC/Cinhibitionequalscytostaticfactor〔J〕.CellDivision,2007,2:412SchmidtA,RauhNR,NiggEAC,etal.Cytostaticfactor:anactivitythatputsthecellcycleonhold〔J〕.JCellSci,2006,119(Pt7:121313KubiakJZ,CiemerychMA.Onthetransitionfromthemeiotictomitoticcellcycleduringearlymousedevelopment〔J〕.IntJDevBi-ol,2008,52(2-3:20114ZhangY,YangX,CaoH,etal.HeatstressinducesCdc2proteindecreasepriortomousespermatogeniccellapoptosis〔J〕.ActaHisto-chem,2008,110(4:27615MehlmannLM.Stopsandstartsinmammalianoocytes:recentadvancesinunderstandingtheregulationofmeioticarrestandoocytematuration〔J〕.Reproduction,2005,130(6:79116ClarkAT,BodnarMS,FoxM,etal.Spontaneousdifferentiationofgermcellsfromhumanembryonicstemcellsinvitro〔J〕.HumMolGenet,2004,13(7:72717TakakuraI,NaitoK,IwamoriN,etal.Inhibitionofmitogenactiva-tedproteinkinaseactivityinducesparthenogeneticactivationandin-creasescyclinBaccumulationduringporcineoocytematuration〔J〕.JReprodDev,2005,51(5:61718SunSC,XiongB,LuSS,etal.MEK1/2isacriticalregulatorofmi-crotubuleassemblyandspindleorganizationduringratoocytemeioticmaturation〔J〕.MolReprodDev,2008,75(10:1542(2010-12-24收稿〔编校邹庆红〕血清肿瘤标志物在上皮性卵巢癌早期诊断中研究进展辛亚兰王卡娜①何荣霞②兰州大学第二医院妇产科(甘肃兰州730030中国图书分类号R737.31文献标识码B1001-4411(201110-1575-04①四川大学华西第二医院妇产科②通讯作者卵巢癌在妇科肿瘤中发病率仅次于宫颈癌和子宫体癌居第三位,而其致死率却占首位〔1〕。卵巢癌早期症状隐匿,鉴别其组织类型及良恶性相当困难,超过70%的患者就诊时已为晚期。资料显示,早期卵巢癌(Ⅰ期5年存活率可达85%以上,晚期卵巢癌(ⅡⅣ期行肿瘤细胞减灭术及化疗的患者5年存活率仅20%30%〔1〕。因此,早期诊断对卵巢癌的预后有重要意义。近年来妇科肿瘤遗传学研究进展迅速,癌基因和抑癌基因,...